| # | Title | Journal | Year | Citations |
|---|
| 1 | Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss | Lancet, The | 2021 | 508 |
| 2 | Current states and future views in photodynamic therapy | Journal of Photochemistry and Photobiology C: Photochemistry Reviews | 2011 | 457 |
| 3 | DNA damage checkpoints in mammals | Mutagenesis | 2006 | 366 |
| 4 | Identification of Viruses in Patients With Postviral Olfactory Dysfunction | Laryngoscope | 2007 | 325 |
| 5 | Clinical diagnostic criteria of IgG4‐related sclerosing cholangitis 2012 | Journal of Hepato-Biliary-Pancreatic Sciences | 2012 | 309 |
| 6 | Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication | Nature | 2013 | 305 |
| 7 | Hepatitis B and C Virus Infection and Hepatocellular Carcinoma in China: A Review of Epidemiology and Control Measures | Journal of Epidemiology | 2011 | 267 |
| 8 | Normal Range of Left Ventricular 2-Dimensional Strain | Circulation Journal | 2012 | 244 |
| 9 | Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression | Cell | 2008 | 238 |
| 10 | Dose‐intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T‐cell leukaemia‐lymphoma: a randomized phase II study | British Journal of Haematology | 2015 | 218 |
| 11 | MECT1-MAML2 Fusion Transcript Defines a Favorable Subset of Mucoepidermoid Carcinoma | Clinical Cancer Research | 2006 | 209 |
| 12 | Functional Interaction between T2R Taste Receptors and G-Protein α Subunits Expressed in Taste Receptor Cells | Journal of Neuroscience | 2003 | 205 |
| 13 | Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus | Neurologia Medico-Chirurgica | 2021 | 203 |
| 14 | Relative Validity of a Short Food Frequency Questionnaire for Assessing Nutrient Intake versus Three-day Weighed Diet Records in Middle-aged Japanese | Journal of Epidemiology | 2005 | 197 |
| 15 | Candesartan, an angiotensin II type-1 receptor blocker, reduces cardiovascular events in patients on chronic haemodialysis—a randomized study | Nephrology Dialysis Transplantation | 2006 | 191 |
| 16 | Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas | Hepatology Research | 2007 | 185 |
| 17 | Efficacy of Short-Term Life-Review Interviews on the Spiritual Well-Being of Terminally Ill Cancer Patients | Journal of Pain and Symptom Management | 2010 | 175 |
| 18 | 14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase | Journal of Biological Chemistry | 2005 | 170 |
| 19 | Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells | Cell Stem Cell | 2015 | 166 |
| 20 | Necessary and Sufficient Role for a Mitosis Skip in Senescence Induction | Molecular Cell | 2014 | 165 |
| 21 | Psychotherapy plus antidepressant for panic disorder with or without agoraphobia | British Journal of Psychiatry | 2006 | 162 |
| 22 | Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage | Human Reproduction | 2012 | 161 |
| 23 | Cancer Prevention by Natural Compounds | Drug Metabolism and Pharmacokinetics | 2004 | 159 |
| 24 | Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation | Molecular and Cellular Biology | 2007 | 153 |
| 25 | Clinicopathological significance of the CRTC3–MAML2 fusion transcript in mucoepidermoid carcinoma | Modern Pathology | 2009 | 153 |
| 26 | Suppression of hepatic stellate cell activation by microRNA-29b | Biochemical and Biophysical Research Communications | 2011 | 152 |
| 27 | Hyperosmolar Mannitol Stimulates Expression of Aquaporins 4 and 9 through a p38 Mitogen-activated Protein Kinase-dependent Pathway in Rat Astrocytes | Journal of Biological Chemistry | 2003 | 150 |
| 28 | Multicentre prospective study of perinatal depression in Japan: incidence and correlates of antenatal and postnatal depression | Archives of Women's Mental Health | 2006 | 150 |
| 29 | JCS/JSCS/JATS/JSVS 2020 Guidelines on the Management of Valvular Heart Disease | Circulation Journal | 2020 | 150 |
| 30 | Oxidative Stress and Ischemia-Reperfusion Injury in Gastrointestinal Tract and Antioxidant, Protective Agents | Journal of Clinical Biochemistry and Nutrition | 2007 | 147 |
| 31 | Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice | Npj Aging and Mechanisms of Disease | 2017 | 141 |
| 32 | PREVENTIVE EFFECTS OF GREEN TEA ON RENAL STONE FORMATION AND THE ROLE OF OXIDATIVE STRESS IN NEPHROLITHIASIS | Journal of Urology | 2005 | 139 |
| 33 | Double-Blind, Placebo-Controlled Clinical Trial With a Rho-Kinase Inhibitor in Pulmonary Arterial Hypertension | Circulation Journal | 2013 | 137 |
| 34 | Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media | PLoS ONE | 2014 | 137 |
| 35 | Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries | Journal of Medicinal Chemistry | 2012 | 135 |
| 36 | Cyclin A–Cdk1 regulates the origin firing program in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 133 |
| 37 | Metabolic profiling of Alzheimer's disease brains | Scientific Reports | 2013 | 133 |
| 38 | Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis | Journal of Bone and Mineral Research | 2017 | 133 |
| 39 | Monitoring of Hepatitis B Virus (HBV) DNA and Risk of HBV Reactivation in B-Cell Lymphoma: A Prospective Observational Study | Clinical Infectious Diseases | 2015 | 130 |
| 40 | Gut Dysbiosis Associated With Hepatitis C Virus Infection | Clinical Infectious Diseases | 2018 | 130 |
| 41 | No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study | Papillomavirus Research (Amsterdam, Netherlands) | 2018 | 128 |
| 42 | Complications Associated With Lateral Interbody Fusion: Nationwide Survey of 2998 Cases During the First 2 Years of Its Use in Japan | Spine | 2017 | 127 |
| 43 | Combined psychotherapy plus antidepressants for panic disorder with or without agoraphobia | The Cochrane Library | 2007 | 124 |
| 44 | Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance | Molecular Cell | 2017 | 124 |
| 45 | Reproducibility of a Short Food Frequency Questionnaire for Japanese General Population | Journal of Epidemiology | 2007 | 122 |
| 46 | TRPM8 activation suppresses cellular viability in human melanoma | American Journal of Physiology - Cell Physiology | 2008 | 117 |
| 47 | Cellular localization of P2X7 receptor mRNA in the rat brain | Brain Research | 2008 | 113 |
| 48 | Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice | Gastroenterology | 2009 | 110 |
| 49 | Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors | Journal of Hepatology | 2011 | 109 |
| 50 | Assembly of High-Density Lipoprotein | Arteriosclerosis, Thrombosis, and Vascular Biology | 2006 | 107 |
