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Top Articles

#TitleJournalYearCitations
1Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal OmegaMolecular Systems Biology201111,616
2Current best practices in single‐cell RNA‐seq analysis: a tutorialMolecular Systems Biology20191,286
3A genome‐scale metabolic reconstruction for Escherichia coli K‐12 MG1655 that accounts for 1260 ORFs and thermodynamic informationMolecular Systems Biology2007952
4Network‐based classification of breast cancer metastasisMolecular Systems Biology2007908
5Deep learning for computational biologyMolecular Systems Biology2016869
6Ultrasensitive proteome analysis using paramagnetic bead technologyMolecular Systems Biology2014853
7Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data setsMolecular Systems Biology2018845
8A comprehensive genome‐scale reconstruction of Escherichia coli metabolism—2011Molecular Systems Biology2011747
9Feedback between p21 and reactive oxygen production is necessary for cell senescenceMolecular Systems Biology2010720
10The protein expression profile of ACE2 in human tissuesMolecular Systems Biology2020710
11Large‐scale mapping of human protein–protein interactions by mass spectrometryMolecular Systems Biology2007688
12Revisiting biomarker discovery by plasma proteomicsMolecular Systems Biology2017651
13Synthetic biology: new engineering rules for an emerging disciplineMolecular Systems Biology2006597
14The quantitative proteome of a human cell lineMolecular Systems Biology2011592
15PREDICT: a method for inferring novel drug indications with application to personalized medicineMolecular Systems Biology2011572
16Omic data from evolved E. coli are consistent with computed optimal growth from genome‐scale modelsMolecular Systems Biology2010546
17A side effect resource to capture phenotypic effects of drugsMolecular Systems Biology2010546
18The endocannabinoid system links gut microbiota to adipogenesisMolecular Systems Biology2010512
19A deep proteome and transcriptome abundance atlas of 29 healthy human tissuesMolecular Systems Biology2019504
20Differential network biologyMolecular Systems Biology2012483
21A uniform proteomics MS/MS analysis platform utilizing open XML file formatsMolecular Systems Biology2005473
22Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coliMolecular Systems Biology2007471
23Shifts in growth strategies reflect tradeoffs in cellular economicsMolecular Systems Biology2009456
24Metabolic networks in motion: 13 C‐based flux analysisMolecular Systems Biology2006448
25The auxin signalling network translates dynamic input into robust patterning at the shoot apexMolecular Systems Biology2011441
26Oscillations and variability in the p53 systemMolecular Systems Biology2006435
27How to infer gene networks from expression profilesMolecular Systems Biology2007411
28Network‐based global inference of human disease genesMolecular Systems Biology2008411
29Metabolomic and transcriptomic stress response of Escherichia coliMolecular Systems Biology2010407
30Phosphotyrosine interactome of the ErbB‐receptor kinase familyMolecular Systems Biology2005394
31Metabolic modeling of a mutualistic microbial communityMolecular Systems Biology2007384
32Engineering microbial biofuel tolerance and export using efflux pumpsMolecular Systems Biology2011384
33Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growthMolecular Systems Biology2011372
34Determinants of translation efficiency and accuracyMolecular Systems Biology2011366
35Systems metabolic engineering of Escherichia coli for L ‐threonine productionMolecular Systems Biology2007361
36Deciphering microbial interactions in synthetic human gut microbiome communitiesMolecular Systems Biology2018359
37Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coliMolecular Systems Biology2007353
38Highly accurate genome sequences of Escherichia coli K‐12 strains MG1655 and W3110Molecular Systems Biology2006352
39Gene‐specific correlation of RNA and protein levels in human cells and tissuesMolecular Systems Biology2016348
40Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraintsMolecular Systems Biology2017345
41Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative modelsMolecular Systems Biology2021337
42A synthetic Escherichia coli predator–prey ecosystemMolecular Systems Biology2008335
43Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbationMolecular Systems Biology2022327
44Predicting selective drug targets in cancer through metabolic networksMolecular Systems Biology2011324
45Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMolecular Systems Biology2013322
46The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loopsMolecular Systems Biology2012314
47Emergence of robust growth laws from optimal regulation of ribosome synthesisMolecular Systems Biology2014314
48Experimental validation of a predicted feedback loop in the multi‐oscillator clock of Arabidopsis thalianaMolecular Systems Biology2006312
49Modular cell biology: retroactivity and insulationMolecular Systems Biology2008312
50Evolution and functional cross‐talk of protein post‐translational modificationsMolecular Systems Biology2013300