| # | Title | Journal | Year | Citations |
|---|
| 1 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 2 | The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity | Nature Medicine | 2001 | 4,370 |
| 3 | Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase | Nature Medicine | 2002 | 3,692 |
| 4 | Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species | Science | 2011 | 3,144 |
| 5 | Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia | Journal of the American Medical Directors Association | 2014 | 3,035 |
| 6 | Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | Nature | 2003 | 2,804 |
| 7 | Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment | Journal of the American Medical Directors Association | 2020 | 2,796 |
| 8 | Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome | Journal of Clinical Investigation | 2006 | 2,339 |
| 9 | Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota | Nature | 2013 | 2,339 |
| 10 | Adiponectin and Adiponectin Receptors | Endocrine Reviews | 2005 | 2,215 |
| 11 | Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C | Nature Genetics | 2009 | 2,124 |
| 12 | Widespread transcription at neuronal activity-regulated enhancers | Nature | 2010 | 2,120 |
| 13 | Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size | Nature Nanotechnology | 2011 | 2,114 |
| 14 | CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity | Nature Medicine | 2009 | 1,887 |
| 15 | Frequent pathway mutations of splicing machinery in myelodysplasia | Nature | 2011 | 1,764 |
| 16 | Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS) | Surgery | 2011 | 1,703 |
| 17 | Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature | Journal of Neuropathology and Experimental Neurology | 2012 | 1,599 |
| 18 | Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery | Surgery | 2011 | 1,596 |
| 19 | Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update | Hepatology International | 2017 | 1,537 |
| 20 | Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport | Science | 1998 | 1,530 |
| 21 | Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein | Cell | 1998 | 1,489 |
| 22 | Kinesin superfamily motor proteins and intracellular transport | Nature Reviews Molecular Cell Biology | 2009 | 1,457 |
| 23 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 24 | The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract | Nature | 1998 | 1,423 |
| 25 | TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity | Nature | 2007 | 1,405 |
| 26 | Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A | Nature Genetics | 2004 | 1,391 |
| 27 | NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells | Blood | 2002 | 1,322 |
| 28 | Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction | Journal of Experimental Medicine | 2006 | 1,320 |
| 29 | Landscape of genetic lesions in 944 patients with myelodysplastic syndromes | Leukemia | 2014 | 1,291 |
| 30 | Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy | Journal of Hepatology | 2003 | 1,287 |
| 31 | PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance | Molecular Cell | 1999 | 1,281 |
| 32 | Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins | Analytical Chemistry | 1998 | 1,262 |
| 33 | Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas | Pancreatology | 2017 | 1,208 |
| 34 | Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus | Journal of Diabetes Investigation | 2010 | 1,206 |
| 35 | RET, ROS1 and ALK fusions in lung cancer | Nature Medicine | 2012 | 1,189 |
| 36 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 37 | Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions | Nature Medicine | 2007 | 1,177 |
| 38 | Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation | Journal of Biological Chemistry | 2002 | 1,149 |
| 39 | Translation, Adaptation, and Validation of the SF-36 Health Survey for Use in Japan | Journal of Clinical Epidemiology | 1998 | 1,146 |
| 40 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2020 | 1,123 |
| 41 | Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis | Nature Genetics | 2003 | 1,111 |
| 42 | Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis | Nature Medicine | 2002 | 1,100 |
| 43 | Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis | Cell | 2014 | 1,097 |
| 44 | Modulation of microRNA processing by p53 | Nature | 2009 | 1,048 |
| 45 | The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women | Osteoporosis International | 2007 | 1,017 |
| 46 | Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D | Nature | 2004 | 1,016 |
| 47 | TGFβ signalling: a complex web in cancer progression | Nature Reviews Cancer | 2010 | 1,008 |
| 48 | Kinesin Transports RNA | Neuron | 2004 | 974 |
| 49 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 959 |
| 50 | Integrated molecular analysis of clear-cell renal cell carcinoma | Nature Genetics | 2013 | 955 |
