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Top Articles

#TitleJournalYearCitations
1The chemokine system in diverse forms of macrophage activation and polarizationTrends in Immunology20044,898
2Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesTrends in Immunology20024,053
3The biology of human natural killer-cell subsetsTrends in Immunology20012,156
4Cytokines sing the blues: inflammation and the pathogenesis of depressionTrends in Immunology20062,123
5The two NF-κB activation pathways and their role in innate and adaptive immunityTrends in Immunology20041,857
6The Nature of Myeloid-Derived Suppressor Cells in the Tumor MicroenvironmentTrends in Immunology20161,587
7Inflammation: the link between insulin resistance, obesity and diabetesTrends in Immunology20041,574
8Endotoxin tolerance: new mechanisms, molecules and clinical significanceTrends in Immunology2009983
9Astrocytes are active players in cerebral innate immunityTrends in Immunology2007977
10The proPO-system: pros and cons for its role in invertebrate immunityTrends in Immunology2008963
11Heme oxygenase-1: unleashing the protective properties of hemeTrends in Immunology2003945
12Macrophage Immunometabolism: Where Are We (Going)?Trends in Immunology2017932
13AMPed up immunity: how antimicrobial peptides have multiple roles in immune defenseTrends in Immunology2009923
14Neutrophil kinetics in health and diseaseTrends in Immunology2010873
15Overcoming T cell exhaustion in infection and cancerTrends in Immunology2015868
16IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and ToleranceTrends in Immunology2016846
17Prostaglandins as modulators of immunityTrends in Immunology2002838
18Adenosine: an endogenous regulator of innate immunityTrends in Immunology2004838
19Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host responseTrends in Immunology2014834
20Nociceptor Sensory Neuron–Immune Interactions in Pain and InflammationTrends in Immunology2017813
21Plant pattern-recognition receptorsTrends in Immunology2014807
22Mechanisms of SARS-CoV-2 Transmission and PathogenesisTrends in Immunology2020805
23Indoleamine 2,3 dioxygenase and metabolic control of immune responsesTrends in Immunology2013797
24TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progressionTrends in Immunology2010774
25Targeting Tumor-Associated Macrophages in CancerTrends in Immunology2019765
26Astrocytes: Key Regulators of NeuroinflammationTrends in Immunology2016715
27Dendritic Cells and Cancer ImmunityTrends in Immunology2016703
28The Intestinal Epithelium: Central Coordinator of Mucosal ImmunityTrends in Immunology2018698
29How stress influences the immune responseTrends in Immunology2003685
30Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and functionTrends in Immunology2011646
31Nitric oxide synthase in innate and adaptive immunity: an updateTrends in Immunology2015644
32Differential macrophage programming in the tumor microenvironmentTrends in Immunology2012641
33IL-17 Signaling: The Yin and the YangTrends in Immunology2017632
34IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammationTrends in Immunology2003596
35Chemokines: multiple levels of leukocyte migration control☆Trends in Immunology2004592
36Neutralizing Antibodies against SARS-CoV-2 and Other Human CoronavirusesTrends in Immunology2020592
37Leucine-rich repeats and pathogen recognition in Toll-like receptorsTrends in Immunology2003577
38Present Yourself! By MHC Class I and MHC Class II MoleculesTrends in Immunology2016577
39Inflammasome activation and IL-1β and IL-18 processing during infectionTrends in Immunology2011541
40Macrophages and cancer: from mechanisms to therapeutic implicationsTrends in Immunology2015541
41Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory responseTrends in Immunology2003538
42The PD-1–PD-L pathway in immunological toleranceTrends in Immunology2006535
43Tolerance, DCs and tryptophan: much ado about IDOTrends in Immunology2003534
44Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation clusterTrends in Immunology2002533
45Emerging role of damage-associated molecular patterns derived from mitochondria in inflammationTrends in Immunology2011532
46Understanding the IL-23–IL-17 immune pathwayTrends in Immunology2006531
47Tolerance and exhaustion: defining mechanisms of T cell dysfunctionTrends in Immunology2014525
48The Role of Astrocytes in CNS InflammationTrends in Immunology2020516
49Microglia: Dynamic Mediators of Synapse Development and PlasticityTrends in Immunology2015514
50Macrophage diversity in cancer revisited in the era of single-cell omicsTrends in Immunology2022486