| # | Title | Journal | Year | Citations |
|---|
| 1 | The Path Forward for Biofuels and Biomaterials | Science | 2006 | 4,935 |
| 2 | Missing heritability and strategies for finding the underlying causes of complex disease | Nature Reviews Genetics | 2010 | 1,511 |
| 3 | The Phaeodactylum genome reveals the evolutionary history of diatom genomes | Nature | 2008 | 1,458 |
| 4 | Ab initio gene identification in metagenomic sequences | Nucleic Acids Research | 2010 | 1,390 |
| 5 | GeneMark.hmm: new solutions for gene finding | Nucleic Acids Research | 1998 | 1,349 |
| 6 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
| 7 | The return of the variance: intraspecific variability in community ecology | Trends in Ecology and Evolution | 2012 | 1,307 |
| 8 | Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice | Cancer Letters | 2008 | 1,044 |
| 9 | GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses | Nucleic Acids Research | 2005 | 917 |
| 10 | The genome of Tetranychus urticae reveals herbivorous pest adaptations | Nature | 2011 | 897 |
| 11 | The genomic substrate for adaptive radiation in African cichlid fish | Nature | 2014 | 874 |
| 12 | Gene prediction in novel fungal genomes using an ab initio algorithm with unsupervised training | Genome Research | 2008 | 800 |
| 13 | Optimal nitrogen-to-phosphorus stoichiometry of phytoplankton | Nature | 2004 | 767 |
| 14 | Gene identification in novel eukaryotic genomes by self-training algorithm | Nucleic Acids Research | 2005 | 746 |
| 15 | Unicellular cyanobacteria fix N2 in the subtropical North Pacific Ocean | Nature | 2001 | 678 |
| 16 | Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies | PLoS Medicine | 2008 | 675 |
| 17 | Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma | Nature Genetics | 2014 | 624 |
| 18 | Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics | Chemical Reviews | 2011 | 615 |
| 19 | Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells | PLoS ONE | 2012 | 596 |
| 20 | GENMARK: Parallel gene recognition for both DNA strands | Computers & Chemistry | 1993 | 580 |
| 21 | De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway | Journal of Biological Chemistry | 2002 | 548 |
| 22 | CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences | Nucleic Acids Research | 2014 | 548 |
| 23 | Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry | Methods | 2005 | 542 |
| 24 | SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism | Journal of Biological Chemistry | 2005 | 537 |
| 25 | Nitrogen fixation byTrichodesmiumspp.: An important source of new nitrogen to the tropical and subtropical North Atlantic Ocean | Global Biogeochemical Cycles | 2005 | 536 |
| 26 | Methods of parentage analysis in natural populations | Molecular Ecology | 2003 | 525 |
| 27 | Opposing Effects of Native and Exotic Herbivores on Plant Invasions | Science | 2006 | 515 |
| 28 | High rates of N2 fixation by unicellular diazotrophs in the oligotrophic Pacific Ocean | Nature | 2004 | 511 |
| 29 | Strengths and Limitations of 16S rRNA Gene Amplicon Sequencing in Revealing Temporal Microbial Community Dynamics | PLoS ONE | 2014 | 508 |
| 30 | Unexpected nondenitrifier nitrous oxide reductase gene diversity and abundance in soils | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 502 |
| 31 | TROPHIC RELATIONSHIPS AND THE NITROGEN ISOTOPIC COMPOSITION OF AMINO ACIDS IN PLANKTON | Ecology | 2002 | 490 |
| 32 | Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and In Vivo: A Potential Risk Factor for Human Neural Tube Defects among Populations Consuming Fumonisin-Contaminated Maize | Journal of Nutrition | 2004 | 484 |
| 33 | The anaerobic oxidation of methane and sulfate reduction in sediments from Gulf of Mexico cold seeps | Chemical Geology | 2004 | 466 |
| 34 | One-component systems dominate signal transduction in prokaryotes | Trends in Microbiology | 2005 | 461 |
| 35 | Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI + ] Prion in Saccharomyces cerevisiae | Genetics | 1997 | 448 |
| 36 | Ab initio modeling of small proteins by iterative TASSER simulations | BMC Biology | 2007 | 439 |
| 37 | Quantitative PCR Targeting 16S rRNA and Reductive Dehalogenase Genes Simultaneously Monitors Multiple Dehalococcoides Strains | Applied and Environmental Microbiology | 2006 | 413 |
| 38 | Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas–Mexico Border | Environmental Health Perspectives | 2006 | 411 |
| 39 | On the presence and role of human gene-body DNA methylation | Oncotarget | 2012 | 409 |
| 40 | Marine Chemical Ecology: Chemical Signals and Cues Structure Marine Populations, Communities, and Ecosystems | Annual Review of Marine Science | 2009 | 406 |
| 41 | Repeatability and Contingency in the Evolution of a Key Innovation in Phage Lambda | Science | 2012 | 401 |
| 42 | Unicellular Cyanobacterial Distributions Broaden the Oceanic N 2 Fixation Domain | Science | 2010 | 394 |
| 43 | Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea ( Coprinus cinereus ) | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 389 |
| 44 | HERBIVORE VS. NUTRIENT CONTROL OF MARINE PRIMARY PRODUCERS: CONTEXT-DEPENDENT EFFECTS | Ecology | 2006 | 385 |
| 45 | Aquatic toxicity testing using the nematode, Caenorhabditis elegans | Environmental Toxicology and Chemistry | 1990 | 383 |
| 46 | Microbiome of the upper troposphere: Species composition and prevalence, effects of tropical storms, and atmospheric implications | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 377 |
| 47 | Phylogenetic limiting similarity and competitive exclusion | Ecology Letters | 2011 | 374 |
| 48 | Herbivore species richness and feeding complementarity affect community structure and function on a coral reef | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 371 |
| 49 | Molecular traces of alternative social organization in a termite genome | Nature Communications | 2014 | 371 |
| 50 | Microbial oceanography of anoxic oxygen minimum zones | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 365 |
