| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging | Annals of Neurology | 1999 | 3,348 |
| 2 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,822 |
| 3 | Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers | Journal of the National Cancer Institute | 2000 | 2,624 |
| 4 | Whole genomes redefine the mutational landscape of pancreatic cancer | Nature | 2015 | 2,204 |
| 5 | Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes | Nature | 2012 | 1,779 |
| 6 | APC mutations occur early during colorectal tumorigenesis | Nature | 1992 | 1,743 |
| 7 | Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis | Annals of Neurology | 1981 | 1,706 |
| 8 | Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature | Journal of Neuropathology and Experimental Neurology | 2012 | 1,663 |
| 9 | The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory | American Journal of Surgical Pathology | 2010 | 1,539 |
| 10 | Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer | Nature | 1994 | 1,528 |
| 11 | c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism | Molecular and Cellular Biology | 1999 | 1,521 |
| 12 | Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo | Neuron | 1996 | 1,484 |
| 13 | Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase | Human Molecular Genetics | 2004 | 1,394 |
| 14 | Gene Expression Profiles in Normal and Cancer Cells | Science | 1997 | 1,313 |
| 15 | Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 | Cell | 2011 | 1,246 |
| 16 | miR-34a repression of SIRT1 regulates apoptosis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 1,212 |
| 17 | The Use of Prostate Specific Antigen, Clinical Stage and Gleason Score to Predict Pathological Stage in Men with Localized Prostate Cancer | Journal of Urology | 1993 | 1,156 |
| 18 | Tissue repair and stem cell renewal in carcinogenesis | Nature | 2004 | 1,138 |
| 19 | Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo | Neuron | 1996 | 1,054 |
| 20 | BACE1 is the major β-secretase for generation of Aβ peptides by neurons | Nature Neuroscience | 2001 | 1,033 |
| 21 | Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors | Journal of the National Cancer Institute | 2000 | 1,031 |
| 22 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins | Neuron | 1997 | 971 |
| 23 | c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 963 |
| 24 | Hedgehog signalling in prostate regeneration, neoplasia and metastasis | Nature | 2004 | 963 |
| 25 | Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm | Human Pathology | 2011 | 947 |
| 26 | Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors | Science | 2000 | 922 |
| 27 | Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients | Nature Medicine | 1996 | 896 |
| 28 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 886 |
| 29 | NONDROPLET ULTRASTRUCTURAL DEMONSTRATION OF CYTOCHROME OXIDASE ACTIVITY WITH A POLYMERIZING OSMIOPHILIC REAGENT, DIAMINOBENZIDINE (DAB) | Journal of Cell Biology | 1968 | 883 |
| 30 | Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients | JAMA - Journal of the American Medical Association | 2021 | 876 |
| 31 | A mouse model for Down syndrome exhibits learning and behaviour deficits | Nature Genetics | 1995 | 870 |
| 32 | A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer | Nature Genetics | 2002 | 823 |
| 33 | Prevalence of Unsuspected Pancreatic Cysts on MDCT | American Journal of Roentgenology | 2008 | 808 |
| 34 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 784 |
| 35 | Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 779 |
| 36 | Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma | Journal of the National Cancer Institute | 2003 | 771 |
| 37 | Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome | American Journal of Pathology | 2000 | 756 |
| 38 | Recent progress in pancreatic cancer | Ca-A Cancer Journal for Clinicians | 2013 | 750 |
| 39 | Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm | Nature | 1997 | 735 |
| 40 | Co-expression of multiple transgenes in mouse CNS: a comparison of strategies | New Biotechnology | 2001 | 735 |
| 41 | GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport | Nature | 2015 | 724 |
| 42 | Hashimoto thyroiditis: Clinical and diagnostic criteria | Autoimmunity Reviews | 2014 | 682 |
| 43 | Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development | Developmental Cell | 2003 | 670 |
| 44 | Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis | Brain Research Bulletin | 1998 | 628 |
| 45 | Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer | Nature Genetics | 2009 | 608 |
| 46 | Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia | Gastroenterology | 2012 | 589 |
| 47 | Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 588 |
| 48 | Fatty Acid Synthase and Cancer: New Application of an Old Pathway | Cancer Research | 2006 | 584 |
| 49 | Clinico‐pathologic studies in dementia | Neurology | 1988 | 581 |
| 50 | Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers | Nature Genetics | 1996 | 581 |
