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#TitleJournalYearCitations
1Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelinesJournal of Extracellular Vesicles20187,596
2Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,789
3SCENIC: single-cell regulatory network inference and clusteringNature Methods20173,562
4Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,158
5Structure and Functions of the Bacterial Microbiota of PlantsAnnual Review of Plant Biology20132,739
6Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisCancer Cell20052,726
7A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domainNature19992,031
8Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysisLancet Oncology, The20101,941
9Landscape of somatic mutations in 560 breast cancer whole-genome sequencesNature20161,836
10The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeuticsNature Reviews Drug Discovery20111,825
11The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothesNature Neuroscience20121,738
12Mutational Processes Molding the Genomes of 21 Breast CancersCell20121,720
13Clinical and biological implications of driver mutations in myelodysplastic syndromesBlood20131,605
14The landscape of cancer genes and mutational processes in breast cancerNature20121,561
15Protein Phase Separation: A New Phase in Cell BiologyTrends in Cell Biology20181,553
16High burden and pervasive positive selection of somatic mutations in normal human skinScience20151,507
17Syndecan–syntenin–ALIX regulates the biogenesis of exosomesNature Cell Biology20121,455
18The Cellular Phase of Alzheimer’s DiseaseCell20161,430
19Brown adipose tissue activity controls triglyceride clearanceNature Medicine20111,393
20Separate jasmonate-dependent and salicylate-dependent defense-response pathways in Arabidopsis are essential for resistance to distinct microbial pathogensProceedings of the National Academy of Sciences of the United States of America19981,389
21Phylogenetic ctDNA analysis depicts early-stage lung cancer evolutionNature20171,366
22Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic EffectsPhysiological Reviews20161,356
23A polygenic burden of rare disruptive mutations in schizophreniaNature20141,320
24The Life History of 21 Breast CancersCell20121,287
25Phenotype molding of stromal cells in the lung tumor microenvironmentNature Medicine20181,212
26Association analysis identifies 65 new breast cancer risk lociNature20171,182
27Universal Patterns of Selection in Cancer and Somatic TissuesCell20171,156
28Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neuronsProceedings of the National Academy of Sciences of the United States of America19981,152
29Identification of the tumour transition states occurring during EMTNature20181,147
30Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expressionProceedings of the National Academy of Sciences of the United States of America20081,076
31Prognostic Role of KRAS and BRAF in Stage II and III Resected Colon Cancer: Results of the Translational Study on the PETACC-3, EORTC 40993, SAKK 60-00 TrialJournal of Clinical Oncology20101,067
32Allele-Specific HLA Loss and Immune Escape in Lung Cancer EvolutionCell20171,023
33Allele-specific copy number analysis of tumorsProceedings of the National Academy of Sciences of the United States of America20101,018
34Large-scale genotyping identifies 41 new loci associated with breast cancer riskNature Genetics2013978
35Concomitant Activation of Jasmonate and Ethylene Response Pathways Is Required for Induction of a Plant Defensin Gene in ArabidopsisPlant Cell1998964
36Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway.Plant Cell1996913
37The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ CellsMolecular Cell2012858
38Single-Cell Transcriptome Atlas of Murine Endothelial CellsCell2020856
39KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumoursEuropean Journal of Cancer2006826
40iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track CollectionsPLoS Computational Biology2014823
41Transduction of mechanical and cytoskeletal cues by YAP and TAZNature Reviews Molecular Cell Biology2012811
42Gene prioritization through genomic data fusionNature Biotechnology2006795
43De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophreniaMolecular Psychiatry2012792
44Auxin and Plant-Microbe InteractionsCold Spring Harbor Perspectives in Biology2011791
45Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer SubtypesAmerican Journal of Human Genetics2019770
46The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentNature Reviews Drug Discovery2014767
47Heterogeneity of genomic evolution and mutational profiles in multiple myelomaNature Communications2014763
48Minimum Information about a Biosynthetic Gene clusterNature Chemical Biology2015743
49KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximabAnnals of Oncology2008742
50Subclonal diversification of primary breast cancer revealed by multiregion sequencingNature Medicine2015730