| # | Title | Journal | Year | Citations |
|---|
| 1 | Millisecond-timescale, genetically targeted optical control of neural activity | Nature Neuroscience | 2005 | 4,110 |
| 2 | OpenSim: Open-Source Software to Create and Analyze Dynamic Simulations of Movement | IEEE Transactions on Biomedical Engineering | 2007 | 3,477 |
| 3 | CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field | Journal of Chemical Theory and Computation | 2016 | 2,567 |
| 4 | Parvalbumin neurons and gamma rhythms enhance cortical circuit performance | Nature | 2009 | 2,258 |
| 5 | Driving fast-spiking cells induces gamma rhythm and controls sensory responses | Nature | 2009 | 2,250 |
| 6 | Association of reactive oxygen species levels and radioresistance in cancer stem cells | Nature | 2009 | 2,232 |
| 7 | Neocortical excitation/inhibition balance in information processing and social dysfunction | Nature | 2011 | 2,036 |
| 8 | Structural and molecular interrogation of intact biological systems | Nature | 2013 | 1,765 |
| 9 | An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues | Nature Methods | 2017 | 1,653 |
| 10 | Optogenetics in Neural Systems | Neuron | 2011 | 1,629 |
| 11 | Multimodal fast optical interrogation of neural circuitry | Nature | 2007 | 1,602 |
| 12 | The Development and Application of Optogenetics | Annual Review of Neuroscience | 2011 | 1,567 |
| 13 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 14 | Optical Deconstruction of Parkinsonian Neural Circuitry | Science | 2009 | 1,385 |
| 15 | The importance of mixed selectivity in complex cognitive tasks | Nature | 2013 | 1,262 |
| 16 | Neural population dynamics during reaching | Nature | 2012 | 1,195 |
| 17 | A Whole-Cell Computational Model Predicts Phenotype from Genotype | Cell | 2012 | 1,177 |
| 18 | Neural substrates of awakening probed with optogenetic control of hypocretin neurons | Nature | 2007 | 1,157 |
| 19 | Natural Neural Projection Dynamics Underlying Social Behavior | Cell | 2014 | 1,121 |
| 20 | Amygdala circuitry mediating reversible and bidirectional control of anxiety | Nature | 2011 | 1,073 |
| 21 | Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning | Science | 2009 | 1,064 |
| 22 | A bioinspired flexible organic artificial afferent nerve | Science | 2018 | 982 |
| 23 | Molecular and Cellular Approaches for Diversifying and Extending Optogenetics | Cell | 2010 | 919 |
| 24 | Neurogrid: A Mixed-Analog-Digital Multichip System for Large-Scale Neural Simulations | Proceedings of the IEEE | 2014 | 902 |
| 25 | CRISPR/Cas9 in Genome Editing and Beyond | Annual Review of Biochemistry | 2016 | 897 |
| 26 | Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures | Nature Protocols | 2010 | 895 |
| 27 | Three-dimensional intact-tissue sequencing of single-cell transcriptional states | Science | 2018 | 890 |
| 28 | Dopamine neurons modulate neural encoding and expression of depression-related behaviour | Nature | 2013 | 874 |
| 29 | Inflammation, fracture and bone repair | Bone | 2016 | 825 |
| 30 | Encoding of conditioned fear in central amygdala inhibitory circuits | Nature | 2010 | 813 |
| 31 | Complete biosynthesis of opioids in yeast | Science | 2015 | 809 |
| 32 | Tuning arousal with optogenetic modulation of locus coeruleus neurons | Nature Neuroscience | 2010 | 800 |
| 33 | Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward | Science | 2010 | 778 |
| 34 | Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration | Integrative Biology (United Kingdom) | 2015 | 772 |
| 35 | Deep learning for cellular image analysis | Nature Methods | 2019 | 754 |
| 36 | Astrocytes Control Breathing Through pH-Dependent Release of ATP | Science | 2010 | 752 |
| 37 | Genetic dissection of an amygdala microcircuit that gates conditioned fear | Nature | 2010 | 745 |
| 38 | Single-cell NF-κB dynamics reveal digital activation and analogue information processing | Nature | 2010 | 736 |
| 39 | An integrated self-healable electronic skin system fabricated via dynamic reconstruction of a nanostructured conducting network | Nature Nanotechnology | 2018 | 736 |
| 40 | OpenSim: Simulating musculoskeletal dynamics and neuromuscular control to study human and animal movement | PLoS Computational Biology | 2018 | 735 |
| 41 | Advanced CLARITY for rapid and high-resolution imaging of intact tissues | Nature Protocols | 2014 | 725 |
| 42 | A causal link between prediction errors, dopamine neurons and learning | Nature Neuroscience | 2013 | 723 |
| 43 | Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits | Journal of Neuroscience | 2006 | 708 |
| 44 | A skin-inspired organic digital mechanoreceptor | Science | 2015 | 708 |
| 45 | Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation | Nature Reviews Molecular Cell Biology | 2016 | 698 |
| 46 | Bile acid metabolites control TH17 and Treg cell differentiation | Nature | 2019 | 695 |
| 47 | Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria | Science | 2006 | 694 |
| 48 | Improving FRET dynamic range with bright green and red fluorescent proteins | Nature Methods | 2012 | 694 |
| 49 | In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2 | Neuron | 2007 | 680 |
| 50 | Large-scale physical activity data reveal worldwide activity inequality | Nature | 2017 | 675 |
