| # | Title | Journal | Year | Citations |
|---|
| 1 | Calcium oscillations increase the efficiency and specificity of gene expression | Nature | 1998 | 1,814 |
| 2 | Neuroligins and neurexins link synaptic function to cognitive disease | Nature | 2008 | 1,577 |
| 3 | Biophysical and molecular mechanisms of Shaker potassium channel inactivation | Science | 1990 | 1,507 |
| 4 | α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro | Science | 2010 | 1,476 |
| 5 | Version 1.2 of the Crystallography and NMR system | Nature Protocols | 2007 | 1,299 |
| 6 | Calcium Channels, Stores, and Oscillations | Annual Review of Cell Biology | 1990 | 1,172 |
| 7 | CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression | Cell | 1996 | 1,055 |
| 8 | Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways | Nature | 2013 | 1,004 |
| 9 | SNARE-mediated membrane fusion | Nature Reviews Molecular Cell Biology | 2001 | 978 |
| 10 | Nomenclature of Voltage-Gated Calcium Channels | Neuron | 2000 | 868 |
| 11 | MicroRNA-mediated conversion of human fibroblasts to neurons | Nature | 2011 | 857 |
| 12 | Vasoregulation by the β1 subunit of the calcium-activated potassium channel | Nature | 2000 | 772 |
| 13 | Neuronal activity triggers calcium waves in hippocampal astrocyte networks | Neuron | 1992 | 764 |
| 14 | Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB | Science | 1990 | 752 |
| 15 | Array Tomography: A New Tool for Imaging the Molecular Architecture and Ultrastructure of Neural Circuits | Neuron | 2007 | 735 |
| 16 | The Molecular Basis of G Protein–Coupled Receptor Activation | Annual Review of Biochemistry | 2018 | 734 |
| 17 | Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission | Annual Review of Neuroscience | 1991 | 674 |
| 18 | Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity | Neuron | 1996 | 660 |
| 19 | Two types of inactivation in Shaker K+ channels: Effects of alterations in the carboxy-terminal region | Neuron | 1991 | 654 |
| 20 | The molecular machinery for secretion is conserved from yeast to neurons. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 619 |
| 21 | Structure of the δ-opioid receptor bound to naltrindole | Nature | 2012 | 607 |
| 22 | Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons | Nature | 1998 | 603 |
| 23 | A genomic perspective on membrane compartment organization | Nature | 2001 | 599 |
| 24 | Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. | Journal of Cell Biology | 1994 | 593 |
| 25 | A Neural Circuit for Memory Specificity and Generalization | Science | 2013 | 585 |
| 26 | A general protocol for the generation of Nanobodies for structural biology | Nature Protocols | 2014 | 571 |
| 27 | Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling | Cell | 2015 | 562 |
| 28 | The minimal cadherin-catenin complex binds to actin filaments under force | Science | 2014 | 532 |
| 29 | Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons | Cell | 2013 | 531 |
| 30 | Assembly of presynaptic active zones from cytoplasmic transport packets | Nature Neuroscience | 2000 | 529 |
| 31 | SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse | Neuron | 2019 | 518 |
| 32 | Shaker potassium channel gating. III: Evaluation of kinetic models for activation. | Journal of General Physiology | 1994 | 506 |
| 33 | The kinetics of synaptic vesicle recycling measured at single presynaptic boutons | Neuron | 1993 | 502 |
| 34 | RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction | Cell | 2011 | 502 |
| 35 | Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation | Nature | 2008 | 501 |
| 36 | Sec6/8 Complex Is Recruited to Cell–Cell Contacts and Specifies Transport Vesicle Delivery to the Basal-Lateral Membrane in Epithelial Cells | Cell | 1998 | 492 |
| 37 | Local potassium signaling couples neuronal activity to vasodilation in the brain | Nature Neuroscience | 2006 | 487 |
| 38 | Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes | Journal of Cell Biology | 1997 | 482 |
| 39 | ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes | Nature | 2015 | 460 |
| 40 | The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals | Nature Neuroscience | 2005 | 457 |
| 41 | The molecular choreography of a store-operated calcium channel | Nature | 2007 | 456 |
| 42 | Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria | Nature | 1993 | 451 |
| 43 | Potassium and Calcium Channels in Lymphocytes | Annual Review of Immunology | 1995 | 449 |
| 44 | Coordinated protein sorting, targeting and distribution in polarized cells | Nature Reviews Molecular Cell Biology | 2008 | 448 |
| 45 | Cortical layer–specific critical dynamics triggering perception | Science | 2019 | 447 |
| 46 | Cardiovascular Regulation in Mice Lacking alpha 2-Adrenergic Receptor Subtypes b and c | Science | 1996 | 439 |
| 47 | Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody | Nature | 2013 | 436 |
| 48 | Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits | Neuron | 1993 | 425 |
| 49 | Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion | Journal of Cell Biology | 2007 | 417 |
| 50 | SNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion | Cell | 1999 | 407 |
