| # | Title | Journal | Year | Citations |
|---|
| 1 | Dermatologist-level classification of skin cancer with deep neural networks | Nature | 2017 | 8,203 |
| 2 | Neurotoxic reactive astrocytes are induced by activated microglia | Nature | 2017 | 4,977 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Phenotypic Analysis of Antigen-Specific T Lymphocytes | Science | 1996 | 3,377 |
| 5 | Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking | Nature Biotechnology | 2016 | 2,802 |
| 6 | Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA | Science | 2005 | 2,389 |
| 7 | Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum | Science | 2011 | 2,097 |
| 8 | The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing | PLoS Biology | 2008 | 2,013 |
| 9 | Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis | Cell | 2015 | 1,791 |
| 10 | The Human Cell Atlas | ELife | 2017 | 1,547 |
| 11 | viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia | Nature Biotechnology | 2013 | 1,481 |
| 12 | An ecological and evolutionary perspective on human–microbe mutualism and disease | Nature | 2007 | 1,430 |
| 13 | Disease Tolerance as a Defense Strategy | Science | 2012 | 1,335 |
| 14 | Analysis of composition of microbiomes: a novel method for studying microbial composition | Microbial Ecology in Health and Disease | 2015 | 1,283 |
| 15 | Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors | Science | 2002 | 1,060 |
| 16 | Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients | Nature Medicine | 1999 | 1,033 |
| 17 | The Agent of Bacillary Angiomatosis | New England Journal of Medicine | 1990 | 985 |
| 18 | Mass Cytometry: Single Cells, Many Features | Cell | 2016 | 978 |
| 19 | Insulin-Dependent Diabetes Mellitus | Cell | 1996 | 929 |
| 20 | Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE | Nature Biotechnology | 2011 | 905 |
| 21 | Three-dimensional intact-tissue sequencing of single-cell transcriptional states | Science | 2018 | 890 |
| 22 | Multiplexed ion beam imaging of human breast tumors | Nature Medicine | 2014 | 881 |
| 23 | Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development | Cell | 2014 | 838 |
| 24 | Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. | Journal of Experimental Medicine | 1994 | 820 |
| 25 | Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation | Nature Reviews Immunology | 2007 | 791 |
| 26 | Virulent strains of Toxoplasma gondii comprise a single clonal lineage | Nature | 1992 | 733 |
| 27 | Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction | Journal of Clinical Microbiology | 1989 | 732 |
| 28 | Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells | Cell | 1994 | 729 |
| 29 | Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 722 |
| 30 | Enterotypes in the landscape of gut microbial community composition | Nature Microbiology | 2018 | 717 |
| 31 | Systemic Immunity Is Required for Effective Cancer Immunotherapy | Cell | 2017 | 708 |
| 32 | Nuclear reprogramming to a pluripotent state by three approaches | Nature | 2010 | 694 |
| 33 | Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities | Immunity | 2000 | 693 |
| 34 | Coordinate regulation and sensory transduction in the control of bacterial virulence | Science | 1989 | 689 |
| 35 | Normalization of mass cytometry data with bead standards | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2013 | 655 |
| 36 | Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens | Nature | 1991 | 649 |
| 37 | Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases | Nature Reviews Immunology | 2008 | 649 |
| 38 | An inducible bundle-forming pilus of enteropathogenic Escherichia coli | Science | 1991 | 641 |
| 39 | Chitin Induces Natural Competence in Vibrio cholerae | Science | 2005 | 600 |
| 40 | A deep profiler's guide to cytometry | Trends in Immunology | 2012 | 596 |
| 41 | A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria | Cell | 2016 | 593 |
| 42 | Salmonella typhimurium invasion induces apoptosis in infected macrophages. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 581 |
| 43 | Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease | Nature | 2020 | 537 |
| 44 | Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes | Immunity | 2012 | 534 |
| 45 | Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 531 |
| 46 | Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire | Nature | 1994 | 527 |
| 47 | Photonic detection of bacterial pathogens in living hosts | Molecular Microbiology | 1995 | 524 |
| 48 | Computational solutions to large-scale data management and analysis | Nature Reviews Genetics | 2010 | 519 |
| 49 | Starvation-induced cross protection against heat or H2O2 challenge in Escherichia coli | Journal of Bacteriology | 1988 | 516 |
| 50 | Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing | Cell Host and Microbe | 2010 | 514 |
