| # | Title | Journal | Year | Citations |
|---|
| 1 | Dermatologist-level classification of skin cancer with deep neural networks | Nature | 2017 | 8,203 |
| 2 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 6,567 |
| 3 | On the LambertW function | Advances in Computational Mathematics | 1996 | 4,751 |
| 4 | Bilateral filtering for gray and color images | Advances in Computational Mathematics | 0 | 4,601 |
| 5 | Probabilistic roadmaps for path planning in high-dimensional configuration spaces | IEEE Transactions on Automation Science and Engineering | 1996 | 4,281 |
| 6 | GREAT improves functional interpretation of cis-regulatory regions | Nature Biotechnology | 2010 | 3,789 |
| 7 | Generalized Cross-Validation as a Method for Choosing a Good Ridge Parameter | Technometrics | 1979 | 2,987 |
| 8 | Approximate nearest neighbors | Technometrics | 1998 | 2,662 |
| 9 | Deep visual-semantic alignments for generating image descriptions | Technometrics | 2015 | 2,539 |
| 10 | Mitigating routing misbehavior in mobile ad hoc networks | Technometrics | 2000 | 2,274 |
| 11 | An Algorithm for Finding Best Matches in Logarithmic Expected Time | ACM Transactions on Mathematical Software | 1977 | 2,150 |
| 12 | RRT-connect: An efficient approach to single-query path planning | ACM Transactions on Mathematical Software | 0 | 1,736 |
| 13 | SIMPLIcity: semantics-sensitive integrated matching for picture libraries | IEEE Transactions on Pattern Analysis and Machine Intelligence | 2001 | 1,727 |
| 14 | Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network | Nature Medicine | 2019 | 1,633 |
| 15 | The Immunological Genome Project: networks of gene expression in immune cells | Nature Immunology | 2008 | 1,576 |
| 16 | OpenMM 7: Rapid development of high performance algorithms for molecular dynamics | PLoS Computational Biology | 2017 | 1,561 |
| 17 | Mediators in the architecture of future information systems | Computer | 1992 | 1,479 |
| 18 | Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++ | PLoS Computational Biology | 2010 | 1,443 |
| 19 | Articulated Hands | International Journal of Robotics Research | 1982 | 1,385 |
| 20 | Architecture of the human regulatory network derived from ENCODE data | Nature | 2012 | 1,384 |
| 21 | Opportunities and obstacles for deep learning in biology and medicine | Journal of the Royal Society Interface | 2018 | 1,282 |
| 22 | GPU Computing | Proceedings of the IEEE | 2008 | 1,266 |
| 23 | MoleculeNet: a benchmark for molecular machine learning | Chemical Science | 2018 | 1,261 |
| 24 | Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae | Nature | 2005 | 1,250 |
| 25 | Molecular Dynamics Simulation for All | Neuron | 2018 | 1,243 |
| 26 | The future of wires | Proceedings of the IEEE | 2001 | 1,103 |
| 27 | Dynamic itemset counting and implication rules for market basket data | Proceedings of the IEEE | 1997 | 1,030 |
| 28 | Mobility network models of COVID-19 explain inequities and inform reopening | Nature | 2021 | 1,016 |
| 29 | ProbCons: Probabilistic consistency-based multiple sequence alignment | Genome Research | 2005 | 982 |
| 30 | Computing Persistent Homology | Discrete and Computational Geometry | 2005 | 981 |
| 31 | LAGAN and Multi-LAGAN: Efficient Tools for Large-Scale Multiple Alignment of Genomic DNA | Genome Research | 2003 | 960 |
| 32 | Approximation Algorithms for Connected Dominating Sets | Algorithmica | 1998 | 955 |
| 33 | Time bounds for selection | Journal of Computer and System Sciences | 1973 | 946 |
| 34 | A Parallel Algorithm for the Efficient Solution of a General Class of Recurrence Equations | IEEE Transactions on Computers | 1973 | 940 |
| 35 | Combining satellite imagery and machine learning to predict poverty | Science | 2016 | 938 |
| 36 | The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes | Science | 2008 | 892 |
| 37 | SignalP 6.0 predicts all five types of signal peptides using protein language models | Nature Biotechnology | 2022 | 883 |
| 38 | Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists | PLoS Medicine | 2018 | 773 |
| 39 | Topic-sensitive pagerank: A context-sensitive ranking algorithm for web search | IEEE Transactions on Knowledge and Data Engineering | 2003 | 765 |
| 40 | Collusion-secure fingerprinting for digital data | IEEE Transactions on Information Theory | 1998 | 760 |
| 41 | A metric for distributions with applications to image databases | IEEE Transactions on Information Theory | 0 | 759 |
| 42 | Modeling polypharmacy side effects with graph convolutional networks | Bioinformatics | 2018 | 741 |
| 43 | Robot Motion Planning: A Distributed Representation Approach | International Journal of Robotics Research | 1991 | 740 |
| 44 | Computer-based personality judgments are more accurate than those made by humans | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 713 |
| 45 | Beyond market baskets | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 707 |
| 46 | Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features | Nature Communications | 2016 | 694 |
| 47 | A Hessenberg-Schur method for the problem AX + XB= C | IEEE Transactions on Automatic Control | 1979 | 682 |
| 48 | Numerical potential field techniques for robot path planning | IEEE Transactions on Systems, Man, and Cybernetics | 1992 | 670 |
| 49 | An integrated software system for analyzing ChIP-chip and ChIP-seq data | Nature Biotechnology | 2008 | 662 |
| 50 | Linking disease associations with regulatory information in the human genome | Genome Research | 2012 | 657 |
