| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Rapid Pneumococcal Evolution in Response to Clinical Interventions | Science | 2011 | 842 |
| 2 | Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer | Nature Communications | 2017 | 794 |
| 3 | Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease | Nature Medicine | 2018 | 774 |
| 4 | Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells | Cancer Cell | 2013 | 678 |
| 5 | Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia | Cell Metabolism | 2008 | 600 |
| 6 | Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 | Science | 2016 | 545 |
| 7 | Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer | Nature Genetics | 2020 | 452 |
| 8 | Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers | Cell | 2016 | 382 |
| 9 | Acetylation of Smc3 by Eco1 Is Required for S Phase Sister Chromatid Cohesion in Both Human and Yeast | Molecular Cell | 2008 | 373 |
| 10 | Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2 | Nature | 2007 | 359 |
| 11 | Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability | Nature Medicine | 2008 | 353 |
| 12 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nature Genetics | 2022 | 342 |
| 13 | The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans | Nature Metabolism | 2019 | 336 |
| 14 | Intron retention is a widespread mechanism of tumor-suppressor inactivation | Nature Genetics | 2015 | 335 |
| 15 | Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study | Journal of Antimicrobial Chemotherapy | 2011 | 322 |
| 16 | Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study | Antimicrobial Agents and Chemotherapy | 2012 | 295 |
| 17 | High Prevalence of Multidrug-Resistant Nonfermenters in Hospital-acquired Pneumonia in Asia | American Journal of Respiratory and Critical Care Medicine | 2011 | 272 |
| 18 | Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases | Nature | 2005 | 269 |
| 19 | Spatiotemporal Evolution of the Primary Glioblastoma Genome | Cancer Cell | 2015 | 255 |
| 20 | Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles | Clinical Cancer Research | 2010 | 250 |
| 21 | High rates of resistance to colistin and polymyxin B in subgroups of Acinetobacter baumannii isolates from Korea | Journal of Antimicrobial Chemotherapy | 2007 | 247 |
| 22 | Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells | Genome Biology | 2015 | 236 |
| 23 | New Inorganic-Based Drug Delivery System of Indole-3-Acetic Acid-Layered Metal Hydroxide Nanohybrids with Controlled Release Rate | Chemistry of Materials | 2007 | 227 |
| 24 | Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 211 |
| 25 | EZH2 Generates a Methyl Degron that Is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex | Molecular Cell | 2012 | 207 |
| 26 | From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism | Molecular Cell | 2020 | 206 |
| 27 | Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients | Nature Communications | 2014 | 204 |
| 28 | Aberrant Methylation ofAPC, MGMT, RASSF2A, andWif-1Genes in Plasma as a Biomarker for Early Detection of Colorectal Cancer | Clinical Cancer Research | 2009 | 202 |
| 29 | Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ | Cell Reports | 2013 | 192 |
| 30 | Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells | Journal of Biological Chemistry | 2002 | 187 |
| 31 | Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss | Nature Neuroscience | 2013 | 186 |
| 32 | Enantioselective Cyanosilylation of Ketones Catalyzed by a Chiral Oxazaborolidinium Ion | Journal of the American Chemical Society | 2005 | 182 |
| 33 | Osmotin Is a Homolog of Mammalian Adiponectin and Controls Apoptosis in Yeast through a Homolog of Mammalian Adiponectin Receptor | Molecular Cell | 2005 | 181 |
| 34 | Oxidative stress‐related PMK‐1 P38 MAPK activation as a mechanism for toxicity of silver nanoparticles to reproduction in the nematode Caenorhabditis elegans | Environmental Toxicology and Chemistry | 2012 | 178 |
| 35 | Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma | Genome Biology | 2016 | 173 |
| 36 | A phylogenetic analysis of Prunus and the Amygdaloideae (Rosaceae) using ITS sequences of nuclear ribosomal DNA | American Journal of Botany | 2001 | 171 |
| 37 | Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH | Cell Metabolism | 2010 | 166 |
| 38 | Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1 | Nature Immunology | 2011 | 164 |
| 39 | Prognostic significance of c‐Met expression in glioblastomas | Cancer | 2009 | 163 |
| 40 | Efficient Mitochondrial Genome Editing by CRISPR/Cas9 | BioMed Research International | 2015 | 161 |
| 41 | Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes | Nature Communications | 2014 | 160 |
| 42 | Inhibition of TRAF6 ubiquitin-ligase activity by PRDX1 leads to inhibition of NFKB activation and autophagy activation | Autophagy | 2018 | 157 |
| 43 | CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche | Cancer Research | 2010 | 155 |
| 44 | PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival | Cell Reports | 2017 | 149 |
| 45 | α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism | Molecular Neurodegeneration | 2018 | 147 |
| 46 | CCDC41 is required for ciliary vesicle docking to the mother centriole | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 146 |
| 47 | Prevalence and detection of low-allele-fraction variants in clinical cancer samples | Nature Communications | 2017 | 146 |
| 48 | Tumor-Specific Methylation in Bronchial Lavage for the Early Detection of Non-Small-Cell Lung Cancer | Journal of Clinical Oncology | 2004 | 145 |
| 49 | MET Signaling Regulates Glioblastoma Stem Cells | Cancer Research | 2012 | 145 |
| 50 | Dual Functions of Highly Potent Graphene Derivative–Poly-l-Lysine Composites To Inhibit Bacteria and Support Human Cells | ACS Nano | 2012 | 144 |
