# | Title | Journal | Year | Citations |
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1 | Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells | Cell | 2009 | 562 |
2 | Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity | Nature Communications | 2014 | 262 |
3 | Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network | Cell Stem Cell | 2019 | 243 |
4 | Hedgehog signalling | Development (Cambridge) | 2016 | 205 |
5 | Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum | Nature Biotechnology | 2010 | 201 |
6 | The seahorse genome and the evolution of its specialized morphology | Nature | 2016 | 201 |
7 | Pick one, but be quick: 5′ splice sites and the problems of too many choices | Genes and Development | 2013 | 193 |
8 | Declining Efficacy of Artemisinin Combination Therapy AgainstP. FalciparumMalaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors | Clinical Infectious Diseases | 2016 | 189 |
9 | Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans | JAMA Neurology | 2020 | 188 |
10 | Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention | JAMA Oncology | 2017 | 157 |
11 | Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF‐κB | Aging Cell | 2011 | 154 |
12 | Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway | Diabetologia | 2011 | 145 |
13 | The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties | Bioscience Reports | 2012 | 144 |
14 | Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore | Cell | 2019 | 140 |
15 | Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad | Nucleic Acids Research | 2009 | 134 |
16 | Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials | ELife | 2014 | 126 |
17 | Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants | Journal of Clinical Oncology | 2022 | 120 |
18 | MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression | Journal of Biological Chemistry | 2014 | 107 |
19 | Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy* | Journal of Biological Chemistry | 2013 | 106 |
20 | Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 98 |
21 | p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6 | Nucleic Acids Research | 2012 | 89 |
22 | Site selectivity of platinum anticancer therapeutics | Nature Chemical Biology | 2008 | 83 |
23 | HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy | Nucleic Acids Research | 2009 | 76 |
24 | Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep Sequencing | Cancer Research | 2011 | 76 |
25 | Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling | Immunity | 2018 | 76 |
26 | Endometrial Receptivity and Human Embryo Implantation | American Journal of Reproductive Immunology | 2011 | 75 |
27 | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder | International Journal of Neuropsychopharmacology | 2017 | 75 |
28 | TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency | Annals of Neurology | 2013 | 74 |
29 | The Parkinson's Disease Genome‐Wide Association Study Locus Browser | Movement Disorders | 2020 | 72 |
30 | Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications | Oncologist | 2021 | 69 |
31 | Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast Differentiation | PLoS Genetics | 2010 | 67 |
32 | Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum Merozoites | PLoS Pathogens | 2008 | 66 |
33 | Human genomic Z-DNA segments probed by the Zα domain of ADAR1 | Nucleic Acids Research | 2009 | 66 |
34 | Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb | Development (Cambridge) | 2011 | 62 |
35 | A PRC2-Dependent Repressive Role of PRDM14 in Human Embryonic Stem Cells and Induced Pluripotent Stem Cell Reprogramming | Stem Cells | 2013 | 61 |
36 | Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum | Nature Communications | 2013 | 61 |
37 | PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells | International Journal of Cardiology | 2014 | 59 |
38 | High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells | Genesis | 2006 | 57 |
39 | Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signaling | Apoptosis: an International Journal on Programmed Cell Death | 2010 | 54 |
40 | Src is activated by the nuclear receptor peroxisome proliferator‐activated receptor β/δ in ultraviolet radiation‐induced skin cancer | EMBO Molecular Medicine | 2014 | 52 |
41 | Transient pearling and vesiculation of membrane tubes under osmotic gradients | Faraday Discussions | 2013 | 49 |
42 | Characterization of the Cancer Spectrum in Men With GermlineBRCA1andBRCA2Pathogenic Variants | JAMA Oncology | 2020 | 49 |
43 | A 3D Fiber‐Hydrogel Based Non‐Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury | Advanced Science | 2021 | 49 |
44 | Physical Organization of DNA by Multiple Non-Specific DNA-Binding Modes of Integration Host Factor (IHF) | PLoS ONE | 2012 | 47 |
45 | The human genome-wide distribution of DNA palindromes | Functional and Integrative Genomics | 2007 | 46 |
46 | An essential role for Grk2 in Hedgehog signalling downstream of Smoothened | EMBO Reports | 2016 | 46 |
47 | Alternate rRNA secondary structures as regulators of translation | Nature Structural and Molecular Biology | 2011 | 45 |
48 | Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy | Journal of the American Society of Nephrology: JASN | 2020 | 45 |
49 | Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine | Frontiers in Immunology | 2019 | 43 |
50 | The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis | Development (Cambridge) | 2016 | 42 |