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Top Articles

#TitleJournalYearCitations
1Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem CellsCell2009562
2Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activityNature Communications2014262
3Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular NetworkCell Stem Cell2019243
4Hedgehog signallingDevelopment (Cambridge)2016205
5Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparumNature Biotechnology2010201
6The seahorse genome and the evolution of its specialized morphologyNature2016201
7Pick one, but be quick: 5′ splice sites and the problems of too many choicesGenes and Development2013193
8Declining Efficacy of Artemisinin Combination Therapy AgainstP. FalciparumMalaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic FactorsClinical Infectious Diseases2016189
9Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and EuropeansJAMA Neurology2020188
10Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed PreventionJAMA Oncology2017157
11Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF‐κBAging Cell2011154
12Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathwayDiabetologia2011145
13The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling propertiesBioscience Reports2012144
14Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in SingaporeCell2019140
15Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetradNucleic Acids Research2009134
16Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentialsELife2014126
17Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic VariantsJournal of Clinical Oncology2022120
18MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 ExpressionJournal of Biological Chemistry2014107
19Muscle-specific MicroRNA1 (miR1) Targets Heat Shock Protein 70 (HSP70) during Dexamethasone-mediated Atrophy*Journal of Biological Chemistry2013106
20Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosisProceedings of the National Academy of Sciences of the United States of America201998
21p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6Nucleic Acids Research201289
22Site selectivity of platinum anticancer therapeuticsNature Chemical Biology200883
23HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapyNucleic Acids Research200976
24Genetic and Structural Variation in the Gastric Cancer Kinome Revealed through Targeted Deep SequencingCancer Research201176
25Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR SignalingImmunity201876
26Endometrial Receptivity and Human Embryo ImplantationAmerican Journal of Reproductive Immunology201175
27Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum DisorderInternational Journal of Neuropsychopharmacology201775
28TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiencyAnnals of Neurology201374
29The Parkinson's Disease Genome‐Wide Association Study Locus BrowserMovement Disorders202072
30Homologous Recombination Deficiency: Cancer Predispositions and Treatment ImplicationsOncologist202169
31Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast DifferentiationPLoS Genetics201067
32Antibodies Targeting the PfRH1 Binding Domain Inhibit Invasion of Plasmodium falciparum MerozoitesPLoS Pathogens200866
33Human genomic Z-DNA segments probed by the Zα domain of ADAR1Nucleic Acids Research200966
34Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limbDevelopment (Cambridge)201162
35A PRC2-Dependent Repressive Role of PRDM14 in Human Embryonic Stem Cells and Induced Pluripotent Stem Cell ReprogrammingStem Cells201361
36Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparumNature Communications201361
37PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cellsInternational Journal of Cardiology201459
38High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cellsGenesis200657
39Insulin-like growth factor 1 protects human neuroblastoma cells SH-EP1 against MPP+-induced apoptosis by AKT/GSK-3β/JNK signalingApoptosis: an International Journal on Programmed Cell Death201054
40Src is activated by the nuclear receptor peroxisome proliferator‐activated receptor β/δ in ultraviolet radiation‐induced skin cancerEMBO Molecular Medicine201452
41Transient pearling and vesiculation of membrane tubes under osmotic gradientsFaraday Discussions201349
42Characterization of the Cancer Spectrum in Men With GermlineBRCA1andBRCA2Pathogenic VariantsJAMA Oncology202049
43A 3D Fiber‐Hydrogel Based Non‐Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord InjuryAdvanced Science202149
44Physical Organization of DNA by Multiple Non-Specific DNA-Binding Modes of Integration Host Factor (IHF)PLoS ONE201247
45The human genome-wide distribution of DNA palindromesFunctional and Integrative Genomics200746
46An essential role for Grk2 in Hedgehog signalling downstream of SmoothenedEMBO Reports201646
47Alternate rRNA secondary structures as regulators of translationNature Structural and Molecular Biology201145
48Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA NephropathyJournal of the American Society of Nephrology: JASN202045
49Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-VaccineFrontiers in Immunology201943
50The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesisDevelopment (Cambridge)201642