Department of Molecular Biology

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#	Title	Journal	Year	Citations
1	Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts	Nature Medicine	2003	521
2	Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis	Nature Medicine	2008	501
3	Raft ceramide in molecular medicine	Oncogene	2003	392
4	Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs	Nature Medicine	2013	313
5	Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications	Cellular Physiology and Biochemistry	2010	299
6	Ceramide-enriched membrane domains	Biochimica Et Biophysica Acta - Molecular Cell Research	2005	282
7	Ceramide-mediated clustering is required for CD95-DISC formation	Oncogene	2003	258
8	Eryptosis, a Window to Systemic Disease	Cellular Physiology and Biochemistry	2008	228
9	Brain membrane lipids in major depression and anxiety disorders	Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids	2015	222
10	Ceramide-enriched membrane domains—Structure and function	Biochimica Et Biophysica Acta - Biomembranes	2009	212
11	Physiological and pathophysiological aspects of ceramide	American Journal of Physiology - Regulatory Integrative and Comparative Physiology	2006	202
12	Rhinoviruses Infect Human Epithelial Cells via Ceramide-enriched Membrane Platforms	Journal of Biological Chemistry	2005	195
13	Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes	Proceedings of the National Academy of Sciences of the United States of America	2008	194
14	A Novel Potassium Channel in Lymphocyte Mitochondria	Journal of Biological Chemistry	2005	188
15	Cell Volume Regulatory Ion Channels in Cell Proliferation and Cell Death	Methods in Enzymology	2007	174
16	Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide	Molecular Psychiatry	2018	166
17	TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis	Oncogene	2006	160
18	Ceramide, membrane rafts and infections	Journal of Molecular Medicine	2004	153
19	Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis	American Journal of Respiratory Cell and Molecular Biology	2010	153
20	Identification of Novel Functional Inhibitors of Acid Sphingomyelinase	PLoS ONE	2011	145
21	A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance	Antiviral Research	2007	142
22	Conjugated bilirubin triggers anemia by inducing erythrocyte death	Hepatology	2015	141
23	Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo	Cancer Cell	2017	138
24	Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak‐independent death of cancer cells	EMBO Molecular Medicine	2012	136
25	Role of Mitochondria in Apoptosis	Experimental Physiology	2003	135
26	Regulation of death receptor signaling and apoptosis by ceramide	Pharmacological Research	2003	133
27	Ceramide and cell death receptor clustering	Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids	2002	132
28	Membrane rafts in host–pathogen interactions	Biochimica Et Biophysica Acta - Biomembranes	2006	131
29	Pseudomonas aeruginosaPyocyanin Induces Neutrophil DeathviaMitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase	Antioxidants and Redox Signaling	2015	122
30	Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation	PLoS ONE	2011	122
31	Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment	Environmental Microbiology	2015	113
32	Ceramide-induced cell death in malignant cells	Cancer Letters	2008	112
33	Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa	EMBO Molecular Medicine	2014	109
34	Acid Sphingomyelinase and Its Redox Amplification in Formation of Lipid Raft Redox Signaling Platforms in Endothelial Cells	Antioxidants and Redox Signaling	2007	107
35	Alveolar inflammation in cystic fibrosis	Journal of Cystic Fibrosis	2010	103
36	Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons	Frontiers in Physiology	2014	103
37	Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis	Biochimica Et Biophysica Acta - Molecular Cell Research	2015	102
38	Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms	Biochemical and Biophysical Research Communications	2003	101
39	Activation of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition and Migration: Implication of a Novel Role of Inflammasome in Atherogenesis	PLoS ONE	2014	100
40	The ceramide system as a novel antidepressant target	Trends in Pharmacological Sciences	2014	96
41	Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation	Oncotarget	2016	95
42	Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: Implications for uptake	Journal of Controlled Release	2010	92
43	Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on Infection	Journal of Immunology	2010	90
44	β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections	Cell Host and Microbe	2017	86
45	Ceramide in Redox Signaling and Cardiovascular Diseases	Cellular Physiology and Biochemistry	2010	85
46	Regulation of hematogenous tumor metastasis by acid sphingomyelinase	EMBO Molecular Medicine	2015	83
47	Pharmacological targeting of ion channels for cancer therapy: In vivo evidences	Biochimica Et Biophysica Acta - Molecular Cell Research	2016	82
48	Mitochondrial ion channels as oncological targets	Oncogene	2014	81
49	Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia	Leukemia	2013	75
50	Modulation of the Voltage-Gated Potassium Channel Kv1.5 by the SGK1 Protein Kinase Involves Inhibition of Channel Ubiquitination	Cellular Physiology and Biochemistry	2008	74

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