| # | Title | Journal | Year | Citations |
|---|
| 1 | Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation | Nature Medicine | 2007 | 1,442 |
| 2 | Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study | Annals of Neurology | 2006 | 1,138 |
| 3 | Diabetic neuropathy | Nature Reviews Disease Primers | 2019 | 692 |
| 4 | NXY-059 for the Treatment of Acute Ischemic Stroke | New England Journal of Medicine | 2007 | 664 |
| 5 | Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target | Lancet Neurology, The | 2011 | 421 |
| 6 | Stroke Risk Profile Predicts White Matter Hyperintensity Volume | Stroke | 2004 | 415 |
| 7 | Midbrain iron content in early Parkinson disease | Neurology | 2008 | 348 |
| 8 | Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 346 |
| 9 | The Role of Inflammation in Depression and Fatigue | Frontiers in Immunology | 2019 | 343 |
| 10 | Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2019 | 276 |
| 11 | Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 | International Journal of Stroke | 2018 | 272 |
| 12 | Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment | JAMA Neurology | 2017 | 263 |
| 13 | Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients | NeuroImage | 2006 | 250 |
| 14 | Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy | Annals of Neurology | 2005 | 242 |
| 15 | A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria | Nature Genetics | 1996 | 215 |
| 16 | Network analysis for a network disorder: The emerging role of graph theory in the study of epilepsy | Epilepsy and Behavior | 2015 | 210 |
| 17 | Endothelial Progenitor Cells During Cerebrovascular Disease | Stroke | 2005 | 205 |
| 18 | Neurologic disease burden in treated HIV/AIDS predicts survival | Neurology | 2010 | 189 |
| 19 | Vertebral Artery Dissection: Warning Symptoms, Clinical Features and Prognosis in 26 Patients | Canadian Journal of Neurological Sciences | 2000 | 182 |
| 20 | Motor neuron syndromes in cancer patients | Annals of Neurology | 1997 | 175 |
| 21 | Canadian stroke best practice recommendations: Secondary prevention of stroke, sixth edition practice guidelines, update 2017 | International Journal of Stroke | 2018 | 175 |
| 22 | Extratemporal White Matter Abnormalities in Mesial Temporal Lobe Epilepsy Demonstrated with Diffusion Tensor Imaging | Epilepsia | 2006 | 161 |
| 23 | Towards a neuroimaging biomarker for amyotrophic lateral sclerosis | Lancet Neurology, The | 2011 | 156 |
| 24 | A recommended scale for cognitive screening in clinical trials of Parkinson's disease | Movement Disorders | 2010 | 155 |
| 25 | Clinical Deterioration After Intravenous Recombinant Tissue Plasminogen Activator Treatment | Stroke | 2007 | 152 |
| 26 | Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial | Lancet, The | 2022 | 151 |
| 27 | Emotional stress and the development of multiple sclerosis: Case-control evidence of a relationship | Journal of Chronic Diseases | 1982 | 149 |
| 28 | Parenteral dexamethasone for acute severe migraine headache: meta-analysis of randomised controlled trials for preventing recurrence | BMJ: British Medical Journal | 2008 | 138 |
| 29 | Validation of quantitative susceptibility mapping with Perls' iron staining for subcortical gray matter | NeuroImage | 2015 | 137 |
| 30 | Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study | NeuroImage | 2010 | 134 |
| 31 | Dopamine transporter imaging as a diagnostic tool for parkinsonism and related disorders in clinical practice | Parkinsonism and Related Disorders | 2015 | 134 |
| 32 | Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment | European Journal of Neurology | 2006 | 132 |
| 33 | A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? | Hippocampus | 2017 | 130 |
| 34 | A 12-Year Prospective Study of Childhood Herpes Simplex Encephalitis: Is There a Broader Spectrum of Disease? | Pediatrics | 2007 | 127 |
| 35 | Disentangling Cognitive-Frailty: Results From the Gait and Brain Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2016 | 125 |
| 36 | Surgical clipping or endovascular coiling for unruptured intracranial aneurysms: a pragmatic randomised trial | Journal of Neurology, Neurosurgery and Psychiatry | 2017 | 117 |
| 37 | Evolution of deep gray matter volume across the human lifespan | Human Brain Mapping | 2017 | 115 |
| 38 | The spectrum of “off” in Parkinson's disease: What have we learned over 40 years? | Parkinsonism and Related Disorders | 2018 | 115 |
| 39 | Laser Speckle Contrast Imaging of Collateral Blood Flow during Acute Ischemic Stroke | Journal of Cerebral Blood Flow and Metabolism | 2010 | 114 |
| 40 | Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail | Psychiatry Research - Neuroimaging | 2007 | 110 |
| 41 | How Well Are Hypertension, Hyperlipidemia, Diabetes, and Smoking Managed After a Stroke or Transient Ischemic Attack? | Stroke | 2002 | 108 |
| 42 | The Use of Antiplatelet Therapy in the Outpatient Setting: Canadian Cardiovascular Society Guidelines | Canadian Journal of Cardiology | 2011 | 106 |
| 43 | Canadian Stroke Best Practice Recommendations: Secondary Prevention of Stroke Guidelines, Update 2014 | International Journal of Stroke | 2015 | 103 |
| 44 | A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Phase III Study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III) | International Journal of Stroke | 2014 | 102 |
| 45 | Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease | Brain | 2021 | 101 |
| 46 | Effect of Hyperthermia on Prognosis After Acute Ischemic Stroke | Stroke | 2009 | 100 |
| 47 | Predictors and Correlates of Interest in Assisted Suicide in the Final Month of Life Among ALS Patients in Oregon and Washington | Journal of Pain and Symptom Management | 2002 | 99 |
| 48 | Impact of Disability Status on Ischemic Stroke Costs in Canada in the First Year | Canadian Journal of Neurological Sciences | 2012 | 96 |
| 49 | Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia | American Journal of Human Genetics | 2016 | 96 |
| 50 | Effect of Implantable vs Prolonged External Electrocardiographic Monitoring on Atrial Fibrillation Detection in Patients With Ischemic Stroke | JAMA - Journal of the American Medical Association | 2021 | 95 |
