| # | Title | Journal | Year | Citations |
|---|
| 1 | World Health Organization 2020 guidelines on physical activity and sedentary behaviour | British Journal of Sports Medicine | 2020 | 4,050 |
| 2 | Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? | Lancet, The | 1998 | 3,390 |
| 3 | New Canadian Physical Activity Guidelines | Applied Physiology, Nutrition and Metabolism | 2011 | 871 |
| 4 | Epidemiology of pediatric inflammatory bowel disease: A systematic review of international trends | Inflammatory Bowel Diseases | 2011 | 779 |
| 5 | Does the CONSORT checklist improve the quality of reports of randomised controlled trials? A systematic review | Medical Journal of Australia | 2006 | 725 |
| 6 | Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro | Gut | 2003 | 530 |
| 7 | Systematic review of physical activity and health in the early years (aged 0–4 years) | Applied Physiology, Nutrition and Metabolism | 2012 | 459 |
| 8 | Canadian Sedentary Behaviour Guidelines for Children and Youth | Applied Physiology, Nutrition and Metabolism | 2011 | 406 |
| 9 | Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? | Pediatric Nephrology | 2003 | 395 |
| 10 | The inclusion of reports of randomised trials published in languages other than English in systematic reviews | Health Technology Assessment | 2003 | 380 |
| 11 | The p38 Mitogen-activated Kinase Pathway Regulates the Human Interleukin-10 Promoter via the Activation of Sp1 Transcription Factor in Lipopolysaccharide-stimulated Human Macrophages | Journal of Biological Chemistry | 2001 | 280 |
| 12 | Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila | Nature Genetics | 2003 | 259 |
| 13 | Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial | Lancet, The | 2019 | 229 |
| 14 | Utilization and Harmonization of Adult Accelerometry Data | Medicine and Science in Sports and Exercise | 2015 | 222 |
| 15 | Biliary Atresia: The Canadian Experience | Journal of Pediatrics | 2007 | 215 |
| 16 | CONSORT: An Evolving Tool to Help Improve the Quality of Reports of Randomized Controlled Trials | JAMA - Journal of the American Medical Association | 1998 | 212 |
| 17 | Type 2 Diabetes, Medication-Induced Diabetes, and Monogenic Diabetes in Canadian Children | Diabetes Care | 2010 | 201 |
| 18 | Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course | Cell Host and Microbe | 2018 | 193 |
| 19 | Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis | Critical Care Medicine | 2018 | 193 |
| 20 | A Randomized, Controlled Trial of Acetaminophen, Ibuprofen, and Codeine for Acute Pain Relief in Children With Musculoskeletal Trauma | Pediatrics | 2007 | 192 |
| 21 | IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha. | Journal of Immunology | 1996 | 184 |
| 22 | Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group | Journal of Clinical Endocrinology and Metabolism | 2017 | 170 |
| 23 | Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome | Acta Neuropathologica | 2017 | 168 |
| 24 | Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary | Journal of Clinical Epidemiology | 2005 | 166 |
| 25 | Advancing the global physical activity agenda: recommendations for future research by the 2020 WHO physical activity and sedentary behavior guidelines development group | International Journal of Behavioral Nutrition and Physical Activity | 2020 | 166 |
| 26 | Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD) | Blood | 2014 | 162 |
| 27 | Nebulized Budesonide for Children with Mild-to-Moderate Croup | New England Journal of Medicine | 1994 | 160 |
| 28 | A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis | Journal of Pediatrics | 1995 | 158 |
| 29 | Regression of target organ damage in children and adolescents with primary hypertension | Pediatric Nephrology | 2010 | 157 |
| 30 | Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis | Lancet Oncology, The | 2015 | 147 |
| 31 | Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: A randomized, controlled trial | Journal of Pediatrics | 1997 | 142 |
| 32 | Introduction to the Canadian 24-Hour Movement Guidelines for Children and Youth: An Integration of Physical Activity, Sedentary Behaviour, and Sleep | Applied Physiology, Nutrition and Metabolism | 2016 | 141 |
| 33 | Surgical Rates for Crohn’s Disease are Decreasing: A Population-Based Time Trend Analysis and Validation Study | American Journal of Gastroenterology | 2017 | 140 |
| 34 | Economic comparison of a tissue adhesive and suturing in the repair of pediatric facial lacerations | Journal of Pediatrics | 1995 | 138 |
| 35 | Nebulized Budesonide and Oral Dexamethasone for Treatment of Croup | JAMA - Journal of the American Medical Association | 1998 | 133 |
| 36 | Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1 | Journal of Biological Chemistry | 2003 | 132 |
| 37 | Rickets | Nature Reviews Disease Primers | 2017 | 131 |
| 38 | Translational Induction of the Inhibitor of Apoptosis Protein HIAP2 during Endoplasmic Reticulum Stress Attenuates Cell Death and Is Mediated via an Inducible Internal Ribosome Entry Site Element | Journal of Biological Chemistry | 2004 | 130 |
| 39 | The Association of Vitamin D Status With Pediatric Critical Illness | Pediatrics | 2012 | 130 |
| 40 | A Randomized, Controlled Trial of Removable Splinting Versus Casting for Wrist Buckle Fractures in Children | Pediatrics | 2006 | 128 |
| 41 | Guides for Reading and Interpreting Systematic Reviews | JAMA Pediatrics | 1998 | 126 |
| 42 | Recent Trends in Hospitalization for Diabetic Ketoacidosis in Ontario Children | Diabetes Care | 2002 | 126 |
| 43 | The Role of Cognitive Deficits in the Development of Eating Disorders | Neuropsychology Review | 2004 | 126 |
| 44 | Time to Epinephrine Administration and Survival From Nonshockable Out-of-Hospital Cardiac Arrest Among Children and Adults | Circulation | 2018 | 122 |
| 45 | Dexamethasone Inhibits IL-12p40 Production in Lipopolysaccharide-Stimulated Human Monocytic Cells by Down-Regulating the Activity of c-Jun N-Terminal Kinase, the Activation Protein-1, and NF-κB Transcription Factors | Journal of Immunology | 2004 | 121 |
| 46 | Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia | Journal of Pediatrics | 2004 | 117 |
| 47 | IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha | Journal of Immunology | 1996 | 112 |
| 48 | Guanidinoacetate methyltransferase (GAMT) deficiency: Outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring | Molecular Genetics and Metabolism | 2014 | 111 |
| 49 | Practice Variation among Pediatric Emergency Departments in the Treatment of Bronchiolitis | Academic Emergency Medicine | 2004 | 103 |
| 50 | What Are the Etiology and Epidemiology of Out-of-hospital Pediatric Cardiopulmonary Arrest in Ontario, Canada? | Academic Emergency Medicine | 2006 | 102 |
