| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
| 3 | Effectiveness of convalescent plasma therapy in severe COVID-19 patients | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 1,638 |
| 4 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,389 |
| 5 | Acute promyelocytic leukemia: from highly fatal to highly curable | Blood | 2008 | 1,133 |
| 6 | Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial | BMJ, The | 2020 | 846 |
| 7 | Viral and host factors related to the clinical outcome of COVID-19 | Nature | 2020 | 773 |
| 8 | Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations | Cell Discovery | 2020 | 728 |
| 9 | Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia | Nature Genetics | 2011 | 718 |
| 10 | Dissection of mechanisms of Chinese medicinal formula Realgar- Indigo naturalis as an effective treatment for promyelocytic leukemia | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 702 |
| 11 | Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure | Circulation Research | 2016 | 694 |
| 12 | Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency | Science | 2006 | 688 |
| 13 | Efficacy of Folic Acid Therapy in Primary Prevention of Stroke Among Adults With Hypertension in China | JAMA - Journal of the American Medical Association | 2015 | 600 |
| 14 | Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity | Cell | 2019 | 575 |
| 15 | Acute promyelocytic leukaemia: novel insights into the mechanisms of cure | Nature Reviews Cancer | 2010 | 429 |
| 16 | Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet | Blood | 2019 | 427 |
| 17 | Challenges to effective cancer control in China, India, and Russia | Lancet Oncology, The | 2014 | 419 |
| 18 | Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease | Hepatobiliary and Pancreatic Diseases International | 2017 | 410 |
| 19 | Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 387 |
| 20 | Berberine activates thermogenesis in white and brown adipose tissue | Nature Communications | 2014 | 383 |
| 21 | Meta-analysis identifies common variants associated with body mass index in east Asians | Nature Genetics | 2012 | 375 |
| 22 | Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair | Nature Genetics | 2015 | 375 |
| 23 | Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China | Cell Discovery | 2020 | 365 |
| 24 | The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti–Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC | Journal of Thoracic Oncology | 2019 | 346 |
| 25 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nature Genetics | 2022 | 342 |
| 26 | Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma | Nature Genetics | 2015 | 329 |
| 27 | Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment | Nature Communications | 2017 | 328 |
| 28 | Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients | EBioMedicine | 2020 | 328 |
| 29 | Identification of type 2 diabetes loci in 433,540 East Asian individuals | Nature | 2020 | 310 |
| 30 | Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems | Molecular Cell | 2019 | 307 |
| 31 | Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia | Blood | 2011 | 300 |
| 32 | Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 290 |
| 33 | Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index | Human Molecular Genetics | 2016 | 283 |
| 34 | Inborn errors of interferon (IFN)‐mediated immunity in humans: insights into the respective roles of IFN‐α/β, IFN‐γ, and IFN‐λ in host defense | Immunological Reviews | 2008 | 281 |
| 35 | Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy | Cell Death and Disease | 2012 | 276 |
| 36 | Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2 | Nature Genetics | 2011 | 268 |
| 37 | Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia | EBioMedicine | 2016 | 261 |
| 38 | Shanghai's life-saving efforts against the current omicron wave of the COVID-19 pandemic | Lancet, The | 2022 | 256 |
| 39 | PD-1/PD-L1 Blockade Therapy in Advanced Non-Small-Cell Lung Cancer: Current Status and Future Directions | Oncologist | 2019 | 255 |
| 40 | Plant Metabolomics: An Indispensable System Biology Tool for Plant Science | International Journal of Molecular Sciences | 2016 | 254 |
| 41 | Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives | Angewandte Chemie - International Edition | 2021 | 254 |
| 42 | A genome-wide association study identifies two new risk loci for Graves' disease | Nature Genetics | 2011 | 253 |
| 43 | Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice | CNS Neuroscience and Therapeutics | 2019 | 253 |
| 44 | Predicting Drug-Target Interaction Networks Based on Functional Groups and Biological Features | PLoS ONE | 2010 | 251 |
| 45 | mRNA-Initiated, Three-Dimensional DNA Amplifier Able to Function inside Living Cells | Journal of the American Chemical Society | 2018 | 249 |
| 46 | A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value | Blood | 2014 | 245 |
| 47 | Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus | Journal of Autoimmunity | 2016 | 240 |
| 48 | Neutrophils in cancer carcinogenesis and metastasis | Journal of Hematology and Oncology | 2021 | 232 |
| 49 | Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification | Journal of the American Chemical Society | 2019 | 231 |
| 50 | Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces | Journal of the American Chemical Society | 2018 | 229 |
