| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,872 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 2,145 |
| 3 | Community proteogenomics reveals insights into the physiology of phyllosphere bacteria | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 794 |
| 4 | Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry | Nature Communications | 2017 | 448 |
| 5 | Large-Scale Arabidopsis Phosphoproteome Profiling Reveals Novel Chloroplast Kinase Substrates and Phosphorylation Networks | Plant Physiology | 2009 | 429 |
| 6 | Nogo-A Inhibits Neurite Outgrowth and Cell Spreading with Three Discrete Regions | Journal of Neuroscience | 2003 | 381 |
| 7 | Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis | Cell | 2018 | 381 |
| 8 | Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease | Circulation | 2013 | 309 |
| 9 | GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells | Nature | 2018 | 292 |
| 10 | Identification of a Vacuolar Sucrose Transporter in Barley and Arabidopsis Mesophyll Cells by a Tonoplast Proteomic Approach | Plant Physiology | 2006 | 291 |
| 11 | Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases | Nature Structural and Molecular Biology | 2013 | 284 |
| 12 | A high-quality catalog of the Drosophila melanogaster proteome | Nature Biotechnology | 2007 | 249 |
| 13 | PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis | EMBO Journal | 2010 | 237 |
| 14 | PARP1 ADP-ribosylates lysine residues of the core histone tails | Nucleic Acids Research | 2010 | 234 |
| 15 | Circadian behavior is light-reprogrammed by plastic DNA methylation | Nature Neuroscience | 2014 | 229 |
| 16 | DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro | Scientific Reports | 2019 | 229 |
| 17 | In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels | Nature Biotechnology | 2021 | 223 |
| 18 | Comparative Functional Analysis of the Caenorhabditis elegans and Drosophila melanogaster Proteomes | PLoS Biology | 2009 | 213 |
| 19 | Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori | PLoS Genetics | 2005 | 199 |
| 20 | Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients | Journal of Allergy and Clinical Immunology | 2018 | 196 |
| 21 | The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep | Science | 2019 | 189 |
| 22 | A comprehensive examination of Nanopore native RNA sequencing for characterization of complex transcriptomes | Nature Communications | 2019 | 181 |
| 23 | Targeted Combinatorial Alternative Splicing Generates Brain Region-Specific Repertoires of Neurexins | Neuron | 2014 | 176 |
| 24 | Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β | Immunity | 2019 | 172 |
| 25 | Robust control of the seasonal expression of the Arabidopsis FLC gene in a fluctuating environment | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 165 |
| 26 | Clinical, radiological, and laboratory characteristics and risk factors for severity and mortality of 289 hospitalized COVID‐19 patients | Allergy: European Journal of Allergy and Clinical Immunology | 2021 | 165 |
| 27 | The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells | Journal of Biological Chemistry | 2013 | 162 |
| 28 | IL-12 protects from psoriasiform skin inflammation | Nature Communications | 2016 | 161 |
| 29 | Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease | PLoS ONE | 2014 | 159 |
| 30 | Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster | PLoS Biology | 2009 | 154 |
| 31 | The CD4+ T Cell-Mediated IFN-γ Response to Helicobacter Infection Is Essential for Clearance and Determines Gastric Cancer Risk | Journal of Immunology | 2009 | 152 |
| 32 | Genome expansion and lineage-specific genetic innovations in the forest pathogenic fungi Armillaria | Nature Ecology and Evolution | 2017 | 152 |
| 33 | Lyso-Phosphatidylcholine Is a Signal in the Arbuscular Mycorrhizal Symbiosis | Science | 2007 | 148 |
| 34 | HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis | Cell | 2020 | 147 |
| 35 | Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid | Journal of Allergy and Clinical Immunology | 2019 | 143 |
| 36 | Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene | Nature | 2010 | 135 |
| 37 | Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2 | Journal of Biological Chemistry | 2007 | 134 |
| 38 | microRNA profiling in Epstein–Barr virus-associated B-cell lymphoma | Nucleic Acids Research | 2011 | 134 |
| 39 | Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations | Nucleic Acids Research | 2014 | 132 |
| 40 | Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions | Nature Communications | 2017 | 132 |
| 41 | The SysteMHC Atlas project | Nucleic Acids Research | 2018 | 131 |
| 42 | Contribution of epigenetic variation to adaptation in Arabidopsis | Nature Communications | 2018 | 127 |
| 43 | Transcriptional Programs of Early Reproductive Stages in Arabidopsis | Plant Physiology | 2004 | 122 |
| 44 | Tight junction, mucin, and inflammasome‐related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice | Allergy: European Journal of Allergy and Clinical Immunology | 2019 | 122 |
| 45 | Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance | Cell Stem Cell | 2020 | 122 |
| 46 | Proteomic analysis of synaptosomes using isotope-coded affinity tags and mass spectrometry | Proteomics | 2005 | 120 |
| 47 | CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres | PLoS ONE | 2011 | 114 |
| 48 | Label‐free determination of protein–ligand binding constants using mass spectrometry and validation using surface plasmon resonance and isothermal titration calorimetry | Journal of Molecular Recognition | 2009 | 113 |
| 49 | Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo | BMC Genomics | 2018 | 110 |
| 50 | Soil restoration with organic amendments: linking cellular functionality and ecosystem processes | Scientific Reports | 2015 | 109 |
