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Top Articles

#TitleJournalYearCitations
1Mechanisms of Pancreatic  -Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few SimilaritiesDiabetes20051,296
2Striatal Restricted Adenosine A2Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry StudyJournal of Neurochemistry1991519
3Evaluation of the Infinium Methylation 450K technologyEpigenomics2011514
4TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASSEMBO Journal2013411
5Anatomy, Function, and Dysfunction of the Right VentricleJournal of the American College of Cardiology2019386
6Clinical and Radiographic Evaluation of the Papilla Level Adjacent to Single-Tooth Dental Implants. A Retrospective Study in the Maxillary Anterior RegionJournal of Periodontology2001376
7The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patientsDiabetologia2007361
8DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patientsEMBO Journal2012355
9A neurocognitive approach to understanding the neurobiology of addictionCurrent Opinion in Neurobiology2013353
10Transcriptome-wide distribution and function of RNA hydroxymethylcytosineScience2016351
11Recommendations for the design and analysis of epigenome-wide association studiesNature Methods2013345
12Regulation of mammalian DNA methyltransferases: a route to new mechanismsEMBO Reports2011316
13Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live birthsAnnals of Medicine2011309
14Galectins and cancerBiochimica Et Biophysica Acta - General Subjects2002306
15What is the evidence that tau pathology spreads through prion-like propagation?Acta Neuropathologica Communications2017272
16Ghrelin Degradation by Serum and Tissue Homogenates: Identification of the Cleavage SitesEndocrinology2004258
17Th1/Th2 Paradigm Extended: Macrophage Polarization as an Unappreciated Pathogen-Driven Escape Mechanism?Frontiers in Immunology2014256
18The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working GroupGut2010247
19Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neuronsJournal of Neuroscience1993246
20DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid LeukemiaCell Reports2014237
21The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseasesLeukemia2014235
22Aristolochic Acids Induce Chronic Renal Failure with Interstitial Fibrosis in Salt-Depleted RatsJournal of the American Society of Nephrology: JASN2002235
23microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratificationBlood2009231
24Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/ macrophage-colony-stimulating factorEuropean Journal of Immunology1997223
25DNA methylation profiling reveals a predominant immune component in breast cancersEMBO Molecular Medicine2011210
26Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working GroupActa Neuropathologica2009196
27Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cellsMolecular Metabolism2017192
28Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injuryKidney International2014188
29Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10European Journal of Immunology1997187
30Galectin-1 Modulates Human Glioblastoma Cell Migration into the Brain Through Modifications to the Actin Cytoskeleton and Levels of Expression of Small GTPasesJournal of Neuropathology and Experimental Neurology2002175
31Distribution of adenosine A2 receptor mRNA in the human brainNeuroscience Letters1991171
32Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organEndocrine-Related Cancer2009163
33Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformationKidney International2008161
34An Integrated View of Aristolochic Acid Nephropathy: Update of the LiteratureInternational Journal of Molecular Sciences2017154
35Galectins Are Differentially Expressed in Supratentorial Pilocytic Astrocytomas, Astrocytomas, Anaplastic Astrocytomas and Glioblastomas, and Significantly Modulate Tumor Astrocyte MigrationBrain Pathology2001153
36A Triadic Neurocognitive Approach to Addiction for Clinical InterventionsFrontiers in Psychiatry2013150
37G protein-coupled receptors: mutations and endocrine diseasesNature Reviews Endocrinology2011145
38Novel targets of antifibrotic and anti-inflammatory treatment in CKDNature Reviews Nephrology2014139
39Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprintingCancer2003137
40Distribution and roles of aquaporins in salivary glandsBiochimica Et Biophysica Acta - Biomembranes2006136
41Localization of cannabinoid receptor in the human developing and adult basal ganglia. Higher levels in the striatonigral neuronsNeuroscience Letters1992126
42Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and InvasionCell Stem Cell2015126
43Safety and usefulness of cryopreservation of ovarian tissue to preserve fertility: a 12-year retrospective analysisHuman Reproduction2014125
44Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's diseaseGastroenterology1993123
45Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushroomsJournal of Ethnopharmacology2012120
46The thyrotrophic role of human chorionic gonadotrophin (hCG) in the early stages of twin (versus single) pregnanciesClinical Endocrinology1997119
47LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestineDevelopmental Biology2009115
48Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivoEMBO Reports2011115
49Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cellsEuropean Journal of Immunology2004113
50Clinical outcomes of laryngopharyngeal reflux treatment: A systematic review and meta‐analysisLaryngoscope2019111