| # | Title | Journal | Year | Citations |
|---|
| 1 | ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation | Nature Cell Biology | 2008 | 590 |
| 2 | Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans | Scientific Reports | 2016 | 488 |
| 3 | Gastric Bypass vs Sleeve Gastrectomy for Type 2 Diabetes Mellitus | Archives of Surgery | 2011 | 385 |
| 4 | Laparoscopic Roux-en-Y Vs. Mini-gastric Bypass for the Treatment of Morbid Obesity: a 10-Year Experience | Obesity Surgery | 2012 | 343 |
| 5 | Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia | Science Translational Medicine | 2017 | 272 |
| 6 | Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma | Cancer | 2003 | 243 |
| 7 | Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial–mesenchymal transition | Oncogene | 2007 | 183 |
| 8 | Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery | JAMA Surgery | 2017 | 161 |
| 9 | Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma | Journal of Biomedical Science | 2004 | 160 |
| 10 | CTGF enhances the motility of breast cancer cells via an integrin-αvβ3–ERK1/2-dependent S100A4-upregulated pathway | Journal of Cell Science | 2007 | 135 |
| 11 | Prognostic histologic features of resected small hepatocellular carcinoma (HCC) in Taiwan. A comparison with resected large HCC | Cancer | 1985 | 134 |
| 12 | Laparoscopic Mini-gastric Bypass: Experience with Tailored Bypass Limb According to Body Weight | Obesity Surgery | 2008 | 134 |
| 13 | Efficient assembly of rat hepatocyte spheroids for tissue engineering applications | | 1996 | 131 |
| 14 | Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties | European Journal of Pharmacology | 1991 | 130 |
| 15 | Risk factors of early redialysis after weaning from postoperative acute renal replacement therapy | Intensive Care Medicine | 2008 | 124 |
| 16 | Single-Anastomosis Gastric Bypass (SAGB): Appraisal of Clinical Evidence | Obesity Surgery | 2014 | 121 |
| 17 | Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1 | Breast Cancer Research and Treatment | 2006 | 120 |
| 18 | PTEN/MMAC1 mutations in hepatocellular carcinomas | Oncogene | 1999 | 118 |
| 19 | High frequency of promoter hypermethylation ofRASSF1A andp16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma | Molecular Carcinogenesis | 2002 | 115 |
| 20 | Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin–chondroitin–hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks | Biomaterials | 2006 | 112 |
| 21 | Magnetic nanoparticle labeling of mesenchymal stem cells without transfection agent: Cellular behavior and capability of detection with clinical 1.5 T magnetic resonance at the single cell level | Magnetic Resonance in Medicine | 2007 | 110 |
| 22 | Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules | Hepatology | 1991 | 109 |
| 23 | Video Endoscopic Sympathectomy Using a Fiberoptic CO2 Laser to Treat Palmar Hyperhidrosis | Neurosurgery | 1992 | 108 |
| 24 | Autonomic Activities in Hyperhidrosis Patients before, during, and after Endoscopic Laser Sympathectomy | Neurosurgery | 1994 | 106 |
| 25 | Immunosuppressive effect of emodin, a free radical generator | European Journal of Pharmacology | 1992 | 103 |
| 26 | Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing | Molecular Cancer | 2015 | 100 |
| 27 | Revisional surgery for laparoscopic minigastric bypass | Surgery for Obesity and Related Diseases | 2011 | 98 |
| 28 | Turbulence Characteristics Downstream of Bileaflet Aortic Valve Prostheses | Journal of Biomechanical Engineering | 2000 | 97 |
| 29 | Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model | Biomaterials | 2012 | 95 |
| 30 | Herbal Extract ofWedelia chinensisAttenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice | Clinical Cancer Research | 2009 | 94 |
| 31 | Hepatocellular carcinoma in childhood. Clinical manifestations and prognosis | Cancer | 1991 | 93 |
| 32 | Clinical Management of Recurrent Hepatocellular Carcinoma | Annals of Surgery | 1995 | 93 |
| 33 | Cartilage tissue engineering on the surface of a novel gelatin-calcium-phosphate biphasic scaffold in a double-chamber bioreactor | Journal of Biomedical Materials Research Part B | 2004 | 92 |
| 34 | Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma | Cancer Letters | 2005 | 91 |
| 35 | Surgical resection for recurrent hepatocellular carcinoma: Prognosis and analysis of risk factors | Surgery | 1996 | 88 |
| 36 | Survival in patients with recurrent hepatocellular carcinoma after primary hepatectomy: Comparative effectiveness of treatment modalities | Surgery | 2012 | 87 |
| 37 | Effects of quercetin combined with anticancer drugs on metastasis-associated factors of gastric cancer cells: in vitro and in vivo studies | Journal of Nutritional Biochemistry | 2018 | 87 |
| 38 | Robotic liver donor right hepatectomy: A pure, minimally invasive approach | Liver Transplantation | 2016 | 86 |
| 39 | Overexpression of Nuclear Protein Kinase CK2 α Catalytic Subunit (CK2α) as a Poor Prognosticator in Human Colorectal Cancer | PLoS ONE | 2011 | 86 |
| 40 | Ruptured aneurysms of the sinus of Valsalva in Oriental patients | Journal of Thoracic and Cardiovascular Surgery | 1990 | 85 |
| 41 | Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions | European Journal of Cancer | 1999 | 81 |
| 42 | The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma—molecular basis and predicting favorable outcome | Modern Pathology | 2008 | 80 |
| 43 | Relationships between three potentiation effects of plyometric training and performance | Scandinavian Journal of Medicine and Science in Sports | 2010 | 80 |
| 44 | Epidemiology of Moyamoya Disease in Taiwan | Stroke | 2014 | 80 |
| 45 | Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts andp53 mutation in hepatocellular carcinoma | International Journal of Cancer | 2003 | 78 |
| 46 | Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas | PLoS ONE | 2012 | 76 |
| 47 | Immunologic evaluation of patients with polychlorinated biphenyl poisoning: Determination of lymphocyte subpopulations | Toxicology and Applied Pharmacology | 1981 | 75 |
| 48 | Early Renal Replacement Therapy in Patients with Postoperative Acute Liver Failure Associated with Acute Renal Failure: Effect on Postoperative Outcomes | Journal of the American College of Surgeons | 2007 | 75 |
| 49 | Aflatoxin B1 and polycyclic aromatic hydrocarbon adducts,p53 mutations andp16 methylation in liver tissue and plasma of hepatocellular carcinoma patients | International Journal of Cancer | 2006 | 74 |
| 50 | Improvement of Insulin Resistance After Obesity Surgery: A Comparison of Gastric Banding and Bypass Procedures | Obesity Surgery | 2008 | 73 |
