| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study | BMJ, The | 2020 | 2,474 |
| 5 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
| 6 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 7 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 8 | Therapeutic developments in pancreatic cancer: current and future perspectives | Nature Reviews Gastroenterology and Hepatology | 2018 | 762 |
| 9 | A review of the volatiles from the healthy human body | Journal of Breath Research | 2014 | 729 |
| 10 | Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations | Nucleic Acids Research | 2015 | 693 |
| 11 | IFITM3 restricts the morbidity and mortality associated with influenza | Nature | 2012 | 668 |
| 12 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease | Clinical Gastroenterology and Hepatology | 2013 | 564 |
| 13 | ECFS best practice guidelines: the 2018 revision | Journal of Cystic Fibrosis | 2018 | 521 |
| 14 | The Frequency of Ras Mutations in Cancer | Cancer Research | 2020 | 515 |
| 15 | Breaking the chains: deubiquitylating enzyme specificity begets function | Nature Reviews Molecular Cell Biology | 2019 | 512 |
| 16 | Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma | JAMA - Journal of the American Medical Association | 2012 | 499 |
| 17 | Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling | Nature Genetics | 2014 | 490 |
| 18 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics‐Guided Warfarin Dosing: 2017 Update | Clinical Pharmacology and Therapeutics | 2017 | 479 |
| 19 | Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study | BMJ, The | 2020 | 478 |
| 20 | Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes | Nature Genetics | 2017 | 472 |
| 21 | Circulating microRNAs as potential markers of human drug-induced liver injury | Hepatology | 2011 | 464 |
| 22 | Ubiquitin: Same Molecule, Different Degradation Pathways | Cell | 2010 | 449 |
| 23 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 447 |
| 24 | Review article: dietary fibre-microbiota interactions | Alimentary Pharmacology and Therapeutics | 2015 | 430 |
| 25 | Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa | Nature Genetics | 2012 | 370 |
| 26 | British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma | Gut | 2019 | 365 |
| 27 | Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study | Brain | 2018 | 352 |
| 28 | Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools | Nucleic Acids Research | 2020 | 352 |
| 29 | Deubiquitylases From Genes to Organism | Physiological Reviews | 2013 | 350 |
| 30 | Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study | BMJ: British Medical Journal | 2012 | 348 |
| 31 | Molecular basis of USP7 inhibition by selective small-molecule inhibitors | Nature | 2017 | 332 |
| 32 | A taxonomy has been developed for outcomes in medical research to help improve knowledge discovery | Journal of Clinical Epidemiology | 2018 | 331 |
| 33 | Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus | Journal of Rheumatology | 2019 | 318 |
| 34 | Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis | New England Journal of Medicine | 2017 | 315 |
| 35 | Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease | Gut | 2012 | 310 |
| 36 | Galectin-3 – A jack-of-all-trades in cancer | Cancer Letters | 2011 | 305 |
| 37 | Evaluation of Human Papilloma Virus Diagnostic Testing in Oropharyngeal Squamous Cell Carcinoma: Sensitivity, Specificity, and Prognostic Discrimination | Clinical Cancer Research | 2011 | 304 |
| 38 | Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis | Nature Genetics | 2012 | 303 |
| 39 | Genome-wide association study reveals two new risk loci for bipolar disorder | Nature Communications | 2014 | 294 |
| 40 | SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection | Nature Communications | 2019 | 286 |
| 41 | The stomach in health and disease | Gut | 2015 | 283 |
| 42 | Methodological consensus on clinical proton MRS of the brain: Review and recommendations | Magnetic Resonance in Medicine | 2019 | 280 |
| 43 | The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers | Cancer Epidemiology Biomarkers and Prevention | 2017 | 278 |
| 44 | Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas) | Gut | 2016 | 274 |
| 45 | Theories on the Pathogenesis of Endometriosis | International Journal of Reproductive Medicine | 2014 | 269 |
| 46 | Early detection of pancreatic cancer | The Lancet Gastroenterology and Hepatology | 2020 | 258 |
| 47 | The demographics of the ubiquitin system | Trends in Cell Biology | 2015 | 255 |
| 48 | Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin | Journal of Cell Biology | 2018 | 253 |
| 49 | Epithelial Cell Shedding and Barrier Function | Veterinary Pathology | 2015 | 250 |
| 50 | Novel genetic loci associated with hippocampal volume | Nature Communications | 2017 | 250 |
