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Top Articles

#TitleJournalYearCitations
1Peripheral cannabinoid receptor, CB2, regulates bone massProceedings of the National Academy of Sciences of the United States of America2006492
2Steroid Sulfatase: Molecular Biology, Regulation, and InhibitionEndocrine Reviews2005468
3Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-riboseNature1999317
4Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potentialJournal of Medicinal Chemistry1994215
5Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphateStructure1999204
6Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp+) Is an Essential Regulator of T-Lymphocyte Ca2+-SignalingJournal of Cell Biology2000166
7Class III β-tubulin expression and in vitro resistance to microtubule targeting agentsBritish Journal of Cancer2010163
8Identification of Mammalian Vps24p as an Effector of Phosphatidylinositol 3,5-Bisphosphate-dependent Endosome CompartmentalizationJournal of Biological Chemistry2003154
9Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid SulfataseJournal of Medicinal Chemistry1998147
10Determination of neo- and d-chiro-Inositol Hexakisphosphate in Soils by Solution 31P NMR SpectroscopyEnvironmental Science & Technology2012124
11Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodentsBritish Journal of Cancer2004108
12Induction of Hippocampal LTD Requires Nitric-Oxide-Stimulated PKG Activity and Ca2+Release From Cyclic ADP-Ribose-Sensitive StoresJournal of Neurophysiology1999106
13NAADP-mediated Ca 2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonistProceedings of the National Academy of Sciences of the United States of America2009101
14InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphataseNature200099
1517β‐hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone‐dependent breast cancerInternational Journal of Cancer200899
16Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal StructureJournal of Medicinal Chemistry201899
172-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents:  Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity†Journal of Medicinal Chemistry200698
18Steroid Sulfatase: A New Target for the Endocrine Therapy of Breast CancerOncologist200794
19The advantages and limitations of protein crystal structuresTrends in Pharmacological Sciences200593
20Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathwayOncogene200491
21Olefin metathesis in non-degassed solvent using a recyclable, polymer supported alkylidenerutheniumChemical Communications200184
22Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd2+ and Zn2+ in MeCNOrganic and Biomolecular Chemistry201282
23Chiral Aromatase and Dual Aromatase−Steroid Sulfatase Inhibitors from the Letrozole Template: Synthesis, Absolute Configuration, and In Vitro ActivityJournal of Medicinal Chemistry200881
24E-Ring Modified Steroids as Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1Journal of Medicinal Chemistry200578
25α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504SProgress in Lipid Research201378
26Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermineBioorganic and Medicinal Chemistry199577
27First Dual Aromatase-Steroid Sulfatase InhibitorsJournal of Medicinal Chemistry200376
28Highly Potent First Examples of Dual Aromatase−Steroid Sulfatase Inhibitors based on a Biphenyl TemplateJournal of Medicinal Chemistry201076
29In vivo inhibition of oestrone sulphatase and dehydroepiandrosterone sulphatase by oestrone-3-O-sulphamateInternational Journal of Cancer199575
30Dual Aromatase−Steroid Sulfatase InhibitorsJournal of Medicinal Chemistry200775
31Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s HealthJournal of Medicinal Chemistry201574
327-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose AntagonistJournal of Biological Chemistry199773
33The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumoursInternational Journal of Cancer200070
34Modification of Estrone at the 6, 16, and 17 Positions:  Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1Journal of Medicinal Chemistry200670
35Active Site Directed Inhibition of Estrone Sulfatase by Nonsteroidal Coumarin SulfamatesJournal of Medicinal Chemistry199669
36A-Ring-Substituted Estrogen-3-O-sulfamates:  Potent Multitargeted Anticancer AgentsJournal of Medicinal Chemistry200569
37Synthetic partial agonists reveal key steps in IP3 receptor activationNature Chemical Biology200969
382′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonistNature Chemical Biology201768
39Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of AntagonistsJournal of Medicinal Chemistry201364
40Synthesis of Selective Non-Ca2+ Mobilizing Inhibitors of D-myo-Inositol 1,4,5-Trisphosphate 5-PhosphataseJournal of Medicinal Chemistry199461
41Inhibition ofin vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamatesInternational Journal of Cancer200461
42Regulation of Ins(3,4,5,6)P4 Signaling by a Reversible Kinase/PhosphataseCurrent Biology200260
43D-Ring Modified Estrone Derivatives as Novel Potent Inhibitors of Steroid SulfataseBioorganic and Medicinal Chemistry200359
44Dual aromatase–sulfatase inhibitors based on the anastrozole template: synthesis, in vitro SAR, molecular modelling and in vivo activityOrganic and Biomolecular Chemistry200758
45Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesisMolecular BioSystems200758
46Aromatase and Dual Aromatase‐Steroid Sulfatase Inhibitors from the Letrozole and Vorozole TemplatesChemMedChem201158
47Structure–Activity Relationship for the First‐in‐Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)ChemMedChem201158
48Fluorescence Lifetime Imaging and FRET‐Induced Intracellular Redistribution of Tat‐Conjugated Quantum Dot Nanoparticles through Interaction with a Phthalocyanine PhotosensitiserSmall201458
49Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug DiscoveryChemistry and Biology201458
50Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1Molecular and Cellular Endocrinology200657