| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 2 | Sensors and regulators of intracellular pH | Nature Reviews Molecular Cell Biology | 2010 | 1,867 |
| 3 | Robust single-particle tracking in live-cell time-lapse sequences | Nature Methods | 2008 | 1,739 |
| 4 | Combination therapy in combating cancer | Oncotarget | 2017 | 1,640 |
| 5 | Molecular subgroups of medulloblastoma: the current consensus | Acta Neuropathologica | 2012 | 1,609 |
| 6 | Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma | Cancer Cell | 2012 | 1,600 |
| 7 | High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities | Cell | 2015 | 1,407 |
| 8 | Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation | Cell | 2010 | 1,219 |
| 9 | The BioGRID interaction database: 2019 update | Nucleic Acids Research | 2019 | 1,160 |
| 10 | Obesity-associated variants within FTO form long-range functional connections with IRX3 | Nature | 2014 | 1,117 |
| 11 | Different immune cells mediate mechanical pain hypersensitivity in male and female mice | Nature Neuroscience | 2015 | 1,102 |
| 12 | Cancer stem cells: an evolving concept | Nature Reviews Cancer | 2012 | 1,075 |
| 13 | The maternal-to-zygotic transition: a play in two acts | Development (Cambridge) | 2009 | 995 |
| 14 | Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization | Science | 2008 | 935 |
| 15 | The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions | Protein Science | 2021 | 934 |
| 16 | Physiological functions of the HECT family of ubiquitin ligases | Nature Reviews Molecular Cell Biology | 2009 | 911 |
| 17 | Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens | Cell Stem Cell | 2009 | 901 |
| 18 | The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass | Developmental Cell | 2009 | 895 |
| 19 | Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas | Acta Neuropathologica | 2012 | 888 |
| 20 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 886 |
| 21 | The whole-genome landscape of medulloblastoma subtypes | Nature | 2017 | 836 |
| 22 | Antimicrobial mechanisms of phagocytes and bacterial evasion strategies | Nature Reviews Microbiology | 2009 | 830 |
| 23 | The Cell Biology of Phagocytosis | Annual Review of Pathology: Mechanisms of Disease | 2012 | 826 |
| 24 | The Distribution and Function of Phosphatidylserine in Cellular Membranes | Annual Review of Biophysics | 2010 | 816 |
| 25 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 784 |
| 26 | Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling | Journal of Cell Biology | 2010 | 763 |
| 27 | Bacterial infection causes stress-induced memory dysfunction in mice | Gut | 2011 | 758 |
| 28 | Probiotics and the gut microbiota in intestinal health and disease | Nature Reviews Gastroenterology and Hepatology | 2010 | 744 |
| 29 | New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs | Cell | 2016 | 740 |
| 30 | The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 | Nature Immunology | 2006 | 727 |
| 31 | Scavenger receptors in homeostasis and immunity | Nature Reviews Immunology | 2013 | 697 |
| 32 | Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation | BBA - Biomembranes | 1989 | 684 |
| 33 | Mechanisms of regulation of the Na+/H+ exchanger | Journal of Membrane Biology | 1986 | 681 |
| 34 | The Genetic Landscape of the Childhood Cancer Medulloblastoma | Science | 2011 | 659 |
| 35 | Phagosome maturation: aging gracefully | Biochemical Journal | 2002 | 616 |
| 36 | The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway | Developmental Cell | 2010 | 614 |
| 37 | Gli Proteins in Development and Disease | Annual Review of Cell and Developmental Biology | 2011 | 614 |
| 38 | T cell receptor ligation induces the formation of dynamically regulated signaling assemblies | Journal of Cell Biology | 2002 | 579 |
| 39 | The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease | Gastroenterology | 2014 | 574 |
| 40 | The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange | Nature | 1998 | 570 |
| 41 | Diversity of the mammalian sodium/proton exchanger SLC9 gene family | Pflugers Archiv European Journal of Physiology | 2004 | 570 |
| 42 | LAMP proteins are required for fusion of lysosomes with phagosomes | EMBO Journal | 2007 | 556 |
| 43 | Epigenomic alterations define lethal CIMP-positive ependymomas of infancy | Nature | 2014 | 539 |
| 44 | Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts | Molecular and Cellular Biology | 1999 | 534 |
| 45 | Activation of antibacterial autophagy by NADPH oxidases | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 514 |
| 46 | Bacteria–autophagy interplay: a battle for survival | Nature Reviews Microbiology | 2014 | 513 |
| 47 | The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway | Journal of Immunology | 2009 | 509 |
| 48 | Timing Is Everything: Making Neurons versus Glia in the Developing Cortex | Neuron | 2007 | 507 |
| 49 | FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst | Development (Cambridge) | 2010 | 499 |
| 50 | Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis | Journal of Cell Biology | 2000 | 493 |
