| # | Title | Journal | Year | Citations |
|---|
|
| 1 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,653 |
| 2 | Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor | Journal of Clinical Oncology | 2003 | 2,181 |
| 3 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,182 |
| 4 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 978 |
| 5 | Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study | Cancer | 1985 | 830 |
| 6 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 770 |
| 7 | Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial | Lancet Oncology, The | 2016 | 603 |
| 8 | Overproduction of large VLDL particles is driven by increased liver fat content in man | Diabetologia | 2006 | 583 |
| 9 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 567 |
| 10 | A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial | Lancet, The | 2007 | 562 |
| 11 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 528 |
| 12 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 499 |
| 13 | VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer | American Journal of Pathology | 1999 | 486 |
| 14 | Trastuzumab emtansine: mechanisms of action and drug resistance | Breast Cancer Research | 2014 | 435 |
| 15 | A role for estrogen receptor β in the regulation of growth of the ventral prostate | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 411 |
| 16 | Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer | Clinical Cancer Research | 2009 | 397 |
| 17 | Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair | Nature Genetics | 2015 | 375 |
| 18 | DNA Copy Number Losses in Human Neoplasms | American Journal of Pathology | 1999 | 362 |
| 19 | VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells | Blood | 2003 | 358 |
| 20 | Psychometric Validation of the Eortc Core Quality of Life Questionnaire, 30-Item Version and A Diagnosis-Specific Module for Head and Neck Cancer Patients | Acta Oncológica | 1992 | 344 |
| 21 | Dietary Fat Content Modifies Liver Fat in Overweight Nondiabetic Subjects | Journal of Clinical Endocrinology and Metabolism | 2005 | 330 |
| 22 | Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer | Nature Genetics | 2017 | 321 |
| 23 | Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients | Neurology | 2001 | 316 |
| 24 | Human breast cancer cells educate macrophages toward the M2 activation status | Breast Cancer Research | 2015 | 308 |
| 25 | Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses | Nature Genetics | 2020 | 304 |
| 26 | FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1 | Journal of Cell Biology | 2009 | 298 |
| 27 | Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families | Journal of Clinical Oncology | 2020 | 296 |
| 28 | Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk | Diabetologia | 2004 | 276 |
| 29 | Genome-wide association analysis identifies three new breast cancer susceptibility loci | Nature Genetics | 2012 | 261 |
| 30 | A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity | Cancer Cell | 2014 | 249 |
| 31 | Vascular endothelial growth factor (VEGF)–C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy | Blood | 2002 | 242 |
| 32 | SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets | Genomics, Proteomics and Bioinformatics | 2022 | 216 |
| 33 | Global Retinoblastoma Presentation and Analysis by National Income Level | JAMA Oncology | 2020 | 211 |
| 34 | Management of locally recurrent nasopharyngeal carcinoma | Cancer Treatment Reviews | 2019 | 210 |
| 35 | Staging and grading of oral squamous cell carcinoma: An update | Oral Oncology | 2020 | 209 |
| 36 | BCL2 Overexpression Associated With Chromosomal Amplification in Diffuse Large B-Cell Lymphoma | Blood | 1997 | 206 |
| 37 | Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers | American Journal of Human Genetics | 2013 | 202 |
| 38 | Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics | Journal of the National Cancer Institute | 2007 | 201 |
| 39 | A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer | Nature Genetics | 2018 | 200 |
| 40 | Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer | Nature Communications | 2020 | 192 |
| 41 | Breast cancer biological subtypes and protein expression predict for the preferential distant metastasis sites: a nationwide cohort study | Breast Cancer Research | 2011 | 190 |
| 42 | Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies | Clinical Cancer Research | 2018 | 190 |
| 43 | Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a | Blood | 2013 | 188 |
| 44 | Meta-analysis in metastatic uveal melanoma to determine progression free and overall survival benchmarks: an international rare cancers initiative (IRCI) ocular melanoma study | Annals of Oncology | 2019 | 186 |
| 45 | Human CD34+ stem cells express the hiwigene, a human homologue of the Drosophila genepiwi | Blood | 2001 | 182 |
| 46 | Overall survival after treatment for metastatic uveal melanoma: a systematic review and meta-analysis | Melanoma Research | 2019 | 181 |
| 47 | FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders | Neurology | 2016 | 178 |
| 48 | Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma | Annals of Oncology | 2019 | 174 |
| 49 | Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors | Genes Chromosomes and Cancer | 2010 | 172 |
| 50 | Chloroplot: An Online Program for the Versatile Plotting of Organelle Genomes | Frontiers in Genetics | 2020 | 169 |
