| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,158 |
| 2 | Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes | New England Journal of Medicine | 2016 | 2,917 |
| 3 | A comprehensive phylogeny of birds (Aves) using targeted next-generation DNA sequencing | Nature | 2015 | 1,415 |
| 4 | The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis | Neuropsychopharmacology | 2004 | 913 |
| 5 | Phase III Randomized Trial of Cisplatin Plus Placebo Compared With Cisplatin Plus Cetuximab in Metastatic/Recurrent Head and Neck Cancer: An Eastern Cooperative Oncology Group Study | Journal of Clinical Oncology | 2005 | 844 |
| 6 | Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics | Nature Biotechnology | 2020 | 835 |
| 7 | PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | New England Journal of Medicine | 2022 | 748 |
| 8 | Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study | Lancet Psychiatry,the | 2018 | 716 |
| 9 | Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer | JAMA Oncology | 2016 | 715 |
| 10 | Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma | Cancer Research | 2013 | 692 |
| 11 | Course of Tic Severity in Tourette Syndrome: The First Two Decades | Pediatrics | 1998 | 636 |
| 12 | Population BRCA1 and BRCA2 Mutation Frequencies and Cancer Penetrances: A Kin–Cohort Study in Ontario, Canada | Journal of the National Cancer Institute | 2006 | 578 |
| 13 | Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders | Nature Neuroscience | 2018 | 539 |
| 14 | Cross-trial prediction of treatment outcome in depression: a machine learning approach | Lancet Psychiatry,the | 2016 | 489 |
| 15 | An Administrative Claims Measure Suitable for Profiling Hospital Performance on the Basis of 30-Day All-Cause Readmission Rates Among Patients With Heart Failure | Circulation: Cardiovascular Quality and Outcomes | 2008 | 460 |
| 16 | Postoperative Radiotherapy for Stage II or III Non–Small-Cell Lung Cancer Using the Surveillance, Epidemiology, and End Results Database | Journal of Clinical Oncology | 2006 | 444 |
| 17 | Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation | Molecular Cell | 2016 | 440 |
| 18 | Birthweight and mortality in adulthood: a systematic review and meta-analysis | International Journal of Epidemiology | 2011 | 432 |
| 19 | Inherited causes of clonal haematopoiesis in 97,691 whole genomes | Nature | 2020 | 432 |
| 20 | International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci | Nature Communications | 2019 | 415 |
| 21 | Changing climates of conflict: A social network experiment in 56 schools | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 412 |
| 22 | Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells | Immunity | 2013 | 394 |
| 23 | Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability | Molecular Psychiatry | 2018 | 386 |
| 24 | Portal hypertension and variceal bleeding: An AASLD single topic symposium | Hepatology | 1998 | 384 |
| 25 | An epidemiologic study of lifting and twisting on the job and risk for acute prolapsed lumbar intervertebral disc | Journal of Orthopaedic Research | 1984 | 375 |
| 26 | The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: Proposal for an Evidence-Based Stage Classification System for the Forthcoming (8th) Edition of the TNM Classification of Malignant Tumors | Journal of Thoracic Oncology | 2014 | 369 |
| 27 | Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci | Molecular Psychiatry | 2014 | 365 |
| 28 | Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial | Lancet, The | 2019 | 346 |
| 29 | Next-generation sequencing in liquid biopsy: cancer screening and early detection | Human Genomics | 2019 | 336 |
| 30 | Estrogen use, APOE, and cognitive decline | Neurology | 2000 | 335 |
| 31 | [ 123 I]β-CIT SPECT imaging assessment of the rate of Parkinson’s disease progression | Neurology | 2001 | 335 |
| 32 | Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors | Nature Medicine | 2020 | 334 |
| 33 | A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA | Science | 2004 | 331 |
| 34 | Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients | Science Translational Medicine | 2020 | 312 |
| 35 | Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine | Archives of General Psychiatry | 2005 | 300 |
| 36 | Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma | Journal of Clinical Oncology | 1999 | 296 |
| 37 | Genome-Wide and Organ-Specific Landscapes of Epigenetic Modifications and Their Relationships to mRNA and Small RNA Transcriptomes in Maize | Plant Cell | 2009 | 295 |
| 38 | Estrogen-Dependent Signaling in a Molecularly Distinct Subclass of Aggressive Prostate Cancer | Journal of the National Cancer Institute | 2008 | 290 |
| 39 | Small cell carcinoma of the urinary bladder | Cancer | 2004 | 273 |
| 40 | Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium | Journal of the National Cancer Institute | 2010 | 266 |
| 41 | Tobacco Control and the Reduction in Smoking-Related Premature Deaths in the United States, 1964-2012 | JAMA - Journal of the American Medical Association | 2014 | 265 |
| 42 | A group bridge approach for variable selection | Biometrika | 2009 | 261 |
| 43 | Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects | Psychopharmacology | 2005 | 255 |
| 44 | Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium | International Journal of Epidemiology | 2012 | 246 |
| 45 | Comparison of ARIMA and Random Forest time series models for prediction of avian influenza H5N1 outbreaks | BMC Bioinformatics | 2014 | 245 |
| 46 | Transcriptome and epigenome landscape of human cortical development modeled in organoids | Science | 2018 | 233 |
| 47 | Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis | Neuropsychopharmacology | 2008 | 230 |
| 48 | The Impact of Co-morbidity on Life Expectancy Among Men with Localized Prostate Cancer | Journal of Urology | 1996 | 227 |
| 49 | Computational prediction of associations between long non-coding RNAs and proteins | BMC Genomics | 2013 | 214 |
| 50 | Prognostic Importance of Early Worsening Renal Function After Initiation of Angiotensin-Converting Enzyme Inhibitor Therapy in Patients With Cardiac Dysfunction | Circulation: Heart Failure | 2011 | 213 |
