| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Risk Factors for Progression to Penetrating Keratoplasty in Patients With Keratoconus | American Journal of Ophthalmology | 2005 | 1,480 |
| 2 | Architecture of the human regulatory network derived from ENCODE data | Nature | 2012 | 1,404 |
| 3 | A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns | Science | 2007 | 1,068 |
| 4 | Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes | PLoS Genetics | 2013 | 856 |
| 5 | Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways | Science | 2015 | 851 |
| 6 | Is there an epidemic of child or adolescent depression? | Journal of Child Psychology and Psychiatry and Allied Disciplines | 2006 | 749 |
| 7 | Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT) | Circulation | 2011 | 730 |
| 8 | Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma | Cancer Discovery | 2017 | 678 |
| 9 | Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review | Journal of the American Medical Informatics Association: JAMIA | 2017 | 611 |
| 10 | Application of New Cholesterol Guidelines to a Population-Based Sample | New England Journal of Medicine | 2014 | 578 |
| 11 | A calibration hierarchy for risk models was defined: from utopia to empirical data | Journal of Clinical Epidemiology | 2016 | 529 |
| 12 | Bariatric Surgery and Long-term Durability of Weight Loss | JAMA Surgery | 2016 | 487 |
| 13 | BRCAPRO Validation, Sensitivity of Genetic Testing of BRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes | Journal of Clinical Oncology | 2002 | 484 |
| 14 | Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes | Kidney International | 2008 | 474 |
| 15 | Absence of a simple code: how transcription factors read the genome | Trends in Biochemical Sciences | 2014 | 468 |
| 16 | Palliative Care in Heart Failure | Journal of the American College of Cardiology | 2017 | 450 |
| 17 | Spatial Modeling With Spatially Varying Coefficient Processes | Journal of the American Statistical Association | 2003 | 443 |
| 18 | Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome | Alzheimer's and Dementia | 2019 | 435 |
| 19 | T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma | Clinical Cancer Research | 2018 | 434 |
| 20 | Irinotecan Fluorouracil Plus Leucovorin Is Not Superior to Fluorouracil Plus Leucovorin Alone As Adjuvant Treatment for Stage III Colon Cancer: Results of CALGB 89803 | Journal of Clinical Oncology | 2007 | 427 |
| 21 | Association Between Bariatric Surgery and Long-term Survival | JAMA - Journal of the American Medical Association | 2015 | 392 |
| 22 | The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis | The Lancet Global Health | 2014 | 389 |
| 23 | A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia | PLoS Genetics | 2009 | 387 |
| 24 | Metabolic network failures in Alzheimer's disease: A biochemical road map | Alzheimer's and Dementia | 2017 | 381 |
| 25 | Psychometric Properties of the UCLA PTSD Reaction Index: Part I | Journal of Traumatic Stress | 2013 | 370 |
| 26 | Diversification of Ig Superfamily Genes in an Invertebrate | Science | 2004 | 367 |
| 27 | Investigating sources of inaccuracy in wearable optical heart rate sensors | Npj Digital Medicine | 2020 | 363 |
| 28 | Overlap Weighting | JAMA - Journal of the American Medical Association | 2020 | 353 |
| 29 | Pathway level analysis of gene expression using singular value decomposition | BMC Bioinformatics | 2005 | 350 |
| 30 | PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data | Genome Biology | 2011 | 343 |
| 31 | Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network | Hepatology | 2014 | 343 |
| 32 | Cardiac Toxicity After Radiotherapy for Stage III Non–Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy | Journal of Clinical Oncology | 2017 | 335 |
| 33 | Incidence and Occurrence of Total (First-Ever and Recurrent) Stroke | Stroke | 1999 | 333 |
| 34 | The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines | PLoS Pathogens | 2012 | 326 |
| 35 | Identifying Frailty in Hospitalized Older Adults with Significant Coronary Artery Disease | Journal of the American Geriatrics Society | 2006 | 323 |
| 36 | Association of Black Race With Prostate Cancer–Specific and Other-Cause Mortality | JAMA Oncology | 2019 | 316 |
| 37 | Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites | Molecular Cell | 2013 | 307 |
| 38 | Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm | ELife | 2020 | 307 |
| 39 | Characterization of BRCA1 and BRCA2 Mutations in a Large United States Sample | Journal of Clinical Oncology | 2006 | 303 |
| 40 | What Explains Racial Differences in the Use of Advance Directives and Attitudes Toward Hospice Care? | Journal of the American Geriatrics Society | 2008 | 303 |
| 41 | Functional mapping — how to map and study the genetic architecture of dynamic complex traits | Nature Reviews Genetics | 2006 | 301 |
| 42 | Viral MicroRNA Targetome of KSHV-Infected Primary Effusion Lymphoma Cell Lines | Cell Host and Microbe | 2011 | 301 |
| 43 | Cabozantinib versus sunitinib as initial therapy for metastatic renal cell carcinoma of intermediate or poor risk (Alliance A031203 CABOSUN randomised trial): Progression-free survival by independent review and overall survival update | European Journal of Cancer | 2018 | 297 |
| 44 | Marginal Mean Models for Dynamic Regimes | Journal of the American Statistical Association | 2001 | 296 |
| 45 | Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503) | Lancet Respiratory Medicine,the | 2018 | 292 |
| 46 | Evaluating Discrimination of Risk Prediction Models | JAMA - Journal of the American Medical Association | 2015 | 291 |
| 47 | Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challenges | European Heart Journal | 2017 | 290 |
| 48 | American Joint Committee on Cancer acceptance criteria for inclusion of risk models for individualized prognosis in the practice of precision medicine | Ca-A Cancer Journal for Clinicians | 2016 | 288 |
| 49 | Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019 | European Urology | 2020 | 286 |
| 50 | Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015 | Annals of Oncology | 2015 | 284 |
