| # | Title | Journal | Year | Citations |
|---|
| 1 | Nucleotide sequence of bacteriophage φX174 DNA | Nature | 1977 | 1,862 |
| 2 | Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain | Biochemical Journal | 2000 | 1,762 |
| 3 | The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation | Biochemical Journal | 1999 | 1,138 |
| 4 | Light Microscopy Techniques for Live Cell Imaging | Science | 2003 | 1,127 |
| 5 | Structure and Mechanism of Helicases and Nucleic Acid Translocases | Annual Review of Biochemistry | 2007 | 1,098 |
| 6 | Membrane proteins, lipids and detergents: not just a soap opera | Biochimica Et Biophysica Acta - Biomembranes | 2004 | 1,080 |
| 7 | The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond | Pflugers Archiv European Journal of Physiology | 2004 | 876 |
| 8 | How do site-specific DNA-binding proteins find their targets? | Nucleic Acids Research | 2004 | 813 |
| 9 | Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain | Biochemical Journal | 2000 | 810 |
| 10 | Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion | Biochemical Journal | 1995 | 778 |
| 11 | Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament | Biophysical Journal | 1993 | 757 |
| 12 | Prion protein is necessary for normal synaptic function | Nature | 1994 | 748 |
| 13 | The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism* | Journal of Biological Chemistry | 2006 | 738 |
| 14 | Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase | Biochemical Journal | 1990 | 714 |
| 15 | Regulation of mitochondrial dehydrogenases by calcium ions | Biochimica Et Biophysica Acta - Bioenergetics | 2009 | 684 |
| 16 | The permeability transition pore complex: another view | Biochimie | 2002 | 650 |
| 17 | Transport of lactate and other monocarboxylates across mammalian plasma membranes | American Journal of Physiology - Cell Physiology | 1993 | 636 |
| 18 | Actin stress fibres | Journal of Cell Science | 2007 | 616 |
| 19 | Wound repair at a glance | Journal of Cell Science | 2009 | 613 |
| 20 | Identification of Monocarboxylate Transporter 8 as a Specific Thyroid Hormone Transporter | Journal of Biological Chemistry | 2003 | 602 |
| 21 | CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression | EMBO Journal | 2000 | 566 |
| 22 | Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase | Biochemical Journal | 1993 | 552 |
| 23 | Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts | Journal of Molecular and Cellular Cardiology | 1993 | 549 |
| 24 | The potential diagram for oxygen at pH 7 | Biochemical Journal | 1988 | 544 |
| 25 | Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase | Journal of Biological Chemistry | 1997 | 525 |
| 26 | The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors | Biochemical Journal | 1975 | 486 |
| 27 | RecBCD Enzyme and the Repair of Double-Stranded DNA Breaks | Microbiology and Molecular Biology Reviews | 2008 | 479 |
| 28 | Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids | Biochemical Journal | 1974 | 462 |
| 29 | Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å | Journal of Molecular Biology | 1979 | 459 |
| 30 | The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death | Current Medicinal Chemistry | 2003 | 454 |
| 31 | Cloning of human satellite III DNA: different components are on different chromosomes | Nucleic Acids Research | 1979 | 453 |
| 32 | SYSTEMS USED FOR THE TRANSPORT OF SUBSTRATES INTO MITOCHONDRIA | British Medical Bulletin | 1968 | 449 |
| 33 | Enzymic mechanisms of superoxide production | Biochimica Et Biophysica Acta - Bioenergetics | 1991 | 430 |
| 34 | Calcium, mitochondria and reperfusion injury: a pore way to die | Biochemical Society Transactions | 2006 | 422 |
| 35 | Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart | Biochimica Et Biophysica Acta - Bioenergetics | 1998 | 418 |
| 36 | Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides | Current Biology | 2004 | 414 |
| 37 | The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism | Biochimica Et Biophysica Acta - Bioenergetics | 1989 | 408 |
| 38 | The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation | Biochemical Journal | 1999 | 404 |
| 39 | The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability | Biochemical Journal | 1969 | 402 |
| 40 | Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B | Biochemical Journal | 1993 | 401 |
| 41 | Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 | Nature | 2003 | 391 |
| 42 | High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds | Journal of Molecular Biology | 1999 | 381 |
| 43 | Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide | Biochemical Journal | 1976 | 378 |
| 44 | Bst-2/HM1.24 Is a Raft-Associated Apical Membrane Protein with an Unusual Topology | Traffic | 2003 | 378 |
| 45 | Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrilogenic Conformations | Science | 1999 | 376 |
| 46 | Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones | Biochemical Journal | 1971 | 369 |
| 47 | On the role of the calcium transport cycle in heart and other mammalian mitochondria | FEBS Letters | 1980 | 366 |
| 48 | Endosomal sorting and signalling: an emerging role for sorting nexins | Nature Reviews Molecular Cell Biology | 2008 | 359 |
| 49 | Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus | Nature | 1991 | 357 |
| 50 | The characterization of myosin–product complexes and of product-release steps during the magnesium ion-dependent adenosine triphosphatase reaction | Biochemical Journal | 1974 | 356 |
