| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas | Cancer Research | 2012 | 740 |
| 2 | Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells | Journal of Cell Biology | 2011 | 529 |
| 3 | DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells | Nature Communications | 2017 | 526 |
| 4 | In Vivo Intradiscal Pressure Measurement in Healthy Individuals and in Patients With Ongoing Back Problems | Spine | 1999 | 489 |
| 5 | Exogenous Tumor Necrosis Factor-Alpha Mimics Nucleus Pulposus-Induced Neuropathology | Spine | 2000 | 298 |
| 6 | BRAF mutations in papillary carcinomas of the thyroid | Oncogene | 2003 | 281 |
| 7 | PD‐L1 expression is mainly regulated by interferon gamma associated with JAK‐STAT pathway in gastric cancer | Cancer Science | 2018 | 251 |
| 8 | Prognostic Factors and Treatment Outcomes for Anaplastic Thyroid Carcinoma: ATC Research Consortium of Japan Cohort Study of 677 Patients | World Journal of Surgery | 2012 | 227 |
| 9 | Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 211 |
| 10 | The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non–Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts | Clinical Cancer Research | 2011 | 190 |
| 11 | Gene aberrations for precision medicine against lung adenocarcinoma | Cancer Science | 2016 | 188 |
| 12 | An Anatomic Study of the Lumbar Plexus with Respect to Retroperitoneal Endoscopic Surgery | Spine | 2003 | 185 |
| 13 | Inflammatory Cytokines Released from the Facet Joint Tissue in Degenerative Lumbar Spinal Disorders | Spine | 2004 | 165 |
| 14 | Incision of the Anulus Fibrosus Induces Nerve Root Morphologic, Vascular, and Functional Changes | Spine | 1996 | 151 |
| 15 | Intraductal extension of primary invasive breast carcinoma treated by breast conservative surgery. Computer graphic three-dimensional reconstruction of the mammary duct-lobular systems | Cancer | 1995 | 149 |
| 16 | Current status of immune checkpoint inhibitors for gastric cancer | Gastric Cancer | 2020 | 149 |
| 17 | Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS) | Age and Ageing | 2015 | 137 |
| 18 | CD8 T Cell Score as a Prognostic Biomarker for Triple Negative Breast Cancer | International Journal of Molecular Sciences | 2020 | 137 |
| 19 | Risk Stratification of 7,732 Hepatectomy Cases in 2011 from the National Clinical Database for Japan | Journal of the American College of Surgeons | 2014 | 133 |
| 20 | Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools | Nature Genetics | 2003 | 131 |
| 21 | M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer | Scientific Reports | 2020 | 127 |
| 22 | Prognostic Impact of Tumor Mutation Burden in Patients With Completely Resected Non–Small Cell Lung Cancer: Brief Report | Journal of Thoracic Oncology | 2018 | 126 |
| 23 | An Anatomic Study of the Sacral Hiatus: A Basis for Successful Caudal Epidural Block | Clinical Journal of Pain | 2004 | 125 |
| 24 | Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors | Clinical Cancer Research | 2013 | 119 |
| 25 | Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 2. Verification of its reliability | Journal of Orthopaedic Science | 2007 | 117 |
| 26 | Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus | Biomaterials | 2009 | 115 |
| 27 | Acute Effects of Nucleus Pulposus on Blood Flow and Endoneurial Fluid Pressure in Rat Dorsal Root Ganglia | Spine | 1998 | 114 |
| 28 | Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer | Annals of Surgical Oncology | 2018 | 114 |
| 29 | Current Venous Thromboembolism Management and Outcomes in Japan | Circulation Journal | 2014 | 112 |
| 30 | Myeloid-derived suppressor cells are increased and correlated with type 2 immune responses, malnutrition, inflammation, and poor prognosis in patients with breast cancer | Oncology Letters | 2017 | 112 |
| 31 | Mechanical Load of the Lumbar Spine During Forward Bending Motion of the Trunk–A Biomechanical Study | Spine | 2006 | 111 |
| 32 | Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain | Glia | 2003 | 110 |
| 33 | Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation and hypoproteinemia in patients with cancer | Oncology Reports | 2012 | 109 |
| 34 | Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 109 |
| 35 | G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer | International Journal of Molecular Sciences | 2020 | 109 |
| 36 | hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53 | Cancer Science | 2003 | 108 |
| 37 | XR (Extended Reality: Virtual Reality, Augmented Reality, Mixed Reality) Technology in Spine Medicine: Status Quo and Quo Vadis | Journal of Clinical Medicine | 2022 | 106 |
| 38 | Mutations and Deletions of the CBP Gene in Human Lung Cancer | Clinical Cancer Research | 2005 | 105 |
| 39 | Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells | American Journal of Pathology | 2003 | 104 |
| 40 | Prevalence of lumbar spinal stenosis, using the diagnostic support tool, and correlated factors in Japan: a population-based study | Journal of Orthopaedic Science | 2013 | 104 |
| 41 | Japanese Orthopaedic Association Back Pain Evaluation Questionnaire. Part 3. Validity study and establishment of the measurement scale | Journal of Orthopaedic Science | 2008 | 102 |
| 42 | Promoter methylation status of DAP‐kinase and RUNX3 genes in neoplastic and non‐neoplastic gastric epithelia | Cancer Science | 2003 | 101 |
| 43 | Anatomic and Radiographic Study of Dorsal Root Ganglia | Spine | 1994 | 98 |
| 44 | Dexamethasone Decreases Blood Flow in Normal Nerves and Dorsal Root Ganglia | Spine | 2002 | 97 |
| 45 | Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer | Clinical Cancer Research | 2017 | 97 |
| 46 | Lumbar Spinal Stenosis Has a Negative Impact on Quality of Life Compared with Other Comorbidities: An Epidemiological Cross‐Sectional Study of 1862 Community‐Dwelling Individuals | Scientific World Journal, The | 2013 | 96 |
| 47 | Expression of Adhesion Molecules and Cytokines on Saphenous Veins in Chronic Venous Insufficiency | Annals of Vascular Surgery | 2000 | 95 |
| 48 | An outcome measure for patients with cervical myelopathy: Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ): Part 1 | Journal of Orthopaedic Science | 2007 | 95 |
| 49 | Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database | Clinical Endocrinology | 2012 | 94 |
| 50 | The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression | Cancer Science | 2004 | 93 |
