| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria | Lancet Neurology, The | 2018 | 4,605 |
| 2 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 4 | Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial | Gastroenterology | 2007 | 1,986 |
| 5 | Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis | Lancet Respiratory Medicine,the | 2019 | 1,866 |
| 6 | Metal nanoparticles: understanding the mechanisms behind antibacterial activity | Journal of Nanobiotechnology | 2017 | 1,487 |
| 7 | Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America | Clinical Infectious Diseases | 2010 | 1,260 |
| 8 | A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection | Nature | 1997 | 1,127 |
| 9 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 10 | Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes | American Journal of Transplantation | 2011 | 997 |
| 11 | Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions | Science | 2002 | 927 |
| 12 | Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data | Cmaj | 2009 | 927 |
| 13 | Receptor trafficking and synaptic plasticity | Nature Reviews Neuroscience | 2004 | 886 |
| 14 | Evolving importance of kidney disease: from subspecialty to global health burden | Lancet, The | 2013 | 874 |
| 15 | The Role of Chest Imaging in Patient Management During the COVID-19 Pandemic | Chest | 2020 | 832 |
| 16 | Long-term depression in the CNS | Nature Reviews Neuroscience | 2010 | 785 |
| 17 | Heterogeneity in telomere length of human chromosomes | Human Molecular Genetics | 1996 | 764 |
| 18 | Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes | Nature Biotechnology | 1998 | 760 |
| 19 | DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLIS | Lancet, The | 1986 | 727 |
| 20 | Consensus Guidelines on the Testing and Clinical Management Issues Associated With HLA and Non-HLA Antibodies in Transplantation | Transplantation | 2013 | 679 |
| 21 | Short telomeres are a risk factor for idiopathic pulmonary fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 665 |
| 22 | Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy | Lancet, The | 2017 | 662 |
| 23 | 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension | Lancet Diabetes and Endocrinology,the | 2017 | 635 |
| 24 | LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β | Neuron | 2007 | 632 |
| 25 | Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood | Journal of Experimental Medicine | 1999 | 611 |
| 26 | Microglia in health and disease | Journal of Neuroscience Research | 2005 | 601 |
| 27 | Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids | Nature Medicine | 2015 | 591 |
| 28 | Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype | Nature Medicine | 2010 | 588 |
| 29 | Economic burden of asthma: a systematic review | BMC Pulmonary Medicine | 2009 | 580 |
| 30 | The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis | Molecular and Cellular Biology | 2003 | 579 |
| 31 | Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation | Blood | 2011 | 556 |
| 32 | Role of oxidatively modified LDL in atherosclerosis | Free Radical Biology and Medicine | 1990 | 550 |
| 33 | Independent Impact of Gout on Mortality and Risk for Coronary Heart Disease | Circulation | 2007 | 546 |
| 34 | Tinzaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients With Active Cancer | JAMA - Journal of the American Medical Association | 2015 | 530 |
| 35 | Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry | Nature Biotechnology | 1998 | 523 |
| 36 | Detectable clonal mosaicism from birth to old age and its relationship to cancer | Nature Genetics | 2012 | 511 |
| 37 | Prevalence of the Metabolic Syndrome in Individuals with Hyperuricemia | American Journal of Medicine | 2007 | 505 |
| 38 | Dual Regulation of NMDA Receptor Functions by Direct Protein-Protein Interactions with the Dopamine D1 Receptor | Cell | 2002 | 492 |
| 39 | Reference for the 2011 revision of the international standards for neurological classification of spinal cord injury | Journal of Spinal Cord Medicine | 2011 | 483 |
| 40 | Does This Dyspneic Patient in the Emergency Department Have Congestive Heart Failure? | JAMA - Journal of the American Medical Association | 2005 | 479 |
| 41 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 42 | Spinal Bone Loss and Ovulatory Disturbances | New England Journal of Medicine | 1990 | 465 |
| 43 | Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections | Clinical Infectious Diseases | 2003 | 464 |
| 44 | Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells | Science | 2000 | 460 |
| 45 | The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic | Lancet, The | 2006 | 460 |
| 46 | IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults | Clinical Infectious Diseases | 2012 | 451 |
| 47 | Chronic Obstructive Pulmonary Disease as a Risk Factor for Cardiovascular Morbidity and Mortality | Proceedings of the American Thoracic Society | 2005 | 449 |
| 48 | DNA-Based Diagnostic Approaches for Identification of Burkholderia cepacia Complex, Burkholderia vietnamiensis, Burkholderia multivorans,Burkholderia stabilis, and Burkholderia cepacia Genomovars I and III | Journal of Clinical Microbiology | 2000 | 446 |
| 49 | Bleeding and Perforation After Outpatient Colonoscopy and Their Risk Factors in Usual Clinical Practice | Gastroenterology | 2008 | 445 |
| 50 | Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study | BMJ: British Medical Journal | 2008 | 443 |
