| # | Title | Journal | Year | Citations |
|---|
| 1 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,708 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS | Neuron | 2011 | 4,176 |
| 4 | mixOmics: An R package for ‘omics feature selection and multiple data integration | PLoS Computational Biology | 2017 | 2,279 |
| 5 | The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 | Annals of Oncology | 2015 | 2,122 |
| 6 | The clonal and mutational evolution spectrum of primary triple-negative breast cancers | Nature | 2012 | 1,778 |
| 7 | Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency | Nature Genetics | 1999 | 1,609 |
| 8 | CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database | Nucleic Acids Research | 2020 | 1,605 |
| 9 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,535 |
| 10 | Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells | Nature | 2011 | 1,071 |
| 11 | Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study | Lancet Oncology, The | 2011 | 1,028 |
| 12 | Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update | Acta Neuropathologica | 2010 | 854 |
| 13 | Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis withSOD1 mutations | Annals of Neurology | 2007 | 840 |
| 14 | The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL) | Clinical Biochemistry | 2001 | 822 |
| 15 | PyClone: statistical inference of clonal population structure in cancer | Nature Methods | 2014 | 817 |
| 16 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 764 |
| 17 | The global burden of paediatric and neonatal sepsis: a systematic review | Lancet Respiratory Medicine,the | 2018 | 630 |
| 18 | Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients | Annals of Oncology | 2014 | 610 |
| 19 | Outbreak of toxoplasmosis associated with municipal drinking water | Lancet, The | 1997 | 607 |
| 20 | Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype | Nature Medicine | 2010 | 588 |
| 21 | A clinically applicable molecular-based classification for endometrial cancers | British Journal of Cancer | 2015 | 579 |
| 22 | Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation | Blood | 2011 | 556 |
| 23 | Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancer | Cancer | 2017 | 552 |
| 24 | Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution | Nature | 2015 | 545 |
| 25 | Molecular characterisation of soft tissue tumours: a gene expression study | Lancet, The | 2002 | 537 |
| 26 | Interferences and contaminants encountered in modern mass spectrometry | Analytica Chimica Acta | 2008 | 528 |
| 27 | MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity | Nature Immunology | 2009 | 528 |
| 28 | Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products | Nature Biotechnology | 2010 | 510 |
| 29 | SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex | Science | 2022 | 488 |
| 30 | deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data | PLoS Computational Biology | 2011 | 477 |
| 31 | The Faces of Fungi database: fungal names linked with morphology, phylogeny and human impacts | Fungal Diversity | 2015 | 471 |
| 32 | Vascular contributions to cognitive impairment and dementia including Alzheimer's disease | Alzheimer's and Dementia | 2015 | 461 |
| 33 | Vascular dysfunction—The disregarded partner of Alzheimer's disease | Alzheimer's and Dementia | 2019 | 454 |
| 34 | Association of Genomic O Island 122 of Escherichia coli EDL 933 with Verocytotoxin-Producing Escherichia coli Seropathotypes That Are Linked to Epidemic and/or Serious Disease | Journal of Clinical Microbiology | 2003 | 444 |
| 35 | Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1 | Neuron | 2003 | 442 |
| 36 | New Onset Diabetes Mellitus in Patients Receiving Calcineurin Inhibitors: A Systematic Review and Meta-Analysis | American Journal of Transplantation | 2004 | 432 |
| 37 | PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer | Cell Metabolism | 2015 | 430 |
| 38 | Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series | Annals of Oncology | 2018 | 416 |
| 39 | Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy | Acta Neuropathologica | 2016 | 380 |
| 40 | CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours | Nature Communications | 2017 | 379 |
| 41 | Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations | Acta Neuropathologica | 2009 | 377 |
| 42 | CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer | Breast Cancer Research | 2012 | 376 |
| 43 | Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 373 |
| 44 | The shaping and functional consequences of the microRNA landscape in breast cancer | Nature | 2013 | 370 |
| 45 | CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors | Clinical Cancer Research | 2019 | 369 |
| 46 | β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment | Nature Medicine | 2007 | 366 |
| 47 | Biocompatibility Testing of Branched and Linear Polyglycidol | Biomacromolecules | 2006 | 361 |
| 48 | Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling | Journal of Pathology | 2013 | 357 |
| 49 | Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling | Science Translational Medicine | 2012 | 356 |
| 50 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
