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Top Articles

#TitleJournalYearCitations
1The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature20124,708
2Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
3Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALSNeuron20114,176
4mixOmics: An R package for ‘omics feature selection and multiple data integrationPLoS Computational Biology20172,279
5The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014Annals of Oncology20152,122
6The clonal and mutational evolution spectrum of primary triple-negative breast cancersNature20121,778
7Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiencyNature Genetics19991,609
8CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance databaseNucleic Acids Research20201,605
9The landscape of cancer genes and mutational processes in breast cancerNature20121,535
10Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cellsNature20111,071
11Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised studyLancet Oncology, The20111,028
12Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an updateActa Neuropathologica2010854
13Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutationsAnnals of Neurology2007840
14The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL)Clinical Biochemistry2001822
15PyClone: statistical inference of clonal population structure in cancerNature Methods2014817
16Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 StudiesPLoS Medicine2010764
17The global burden of paediatric and neonatal sepsis: a systematic reviewLancet Respiratory Medicine,the2018630
18Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patientsAnnals of Oncology2014610
19Outbreak of toxoplasmosis associated with municipal drinking waterLancet, The1997607
20Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotypeNature Medicine2010588
21A clinically applicable molecular-based classification for endometrial cancersBritish Journal of Cancer2015579
22Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylationBlood2011556
23Confirmation of ProMisE: A simple, genomics‐based clinical classifier for endometrial cancerCancer2017552
24Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolutionNature2015545
25Molecular characterisation of soft tissue tumours: a gene expression studyLancet, The2002537
26Interferences and contaminants encountered in modern mass spectrometryAnalytica Chimica Acta2008528
27MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunityNature Immunology2009528
28Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage productsNature Biotechnology2010510
29SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complexScience2022488
30deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq DataPLoS Computational Biology2011477
31The Faces of Fungi database: fungal names linked with morphology, phylogeny and human impactsFungal Diversity2015471
32Vascular contributions to cognitive impairment and dementia including Alzheimer's diseaseAlzheimer's and Dementia2015461
33Vascular dysfunction—The disregarded partner of Alzheimer's diseaseAlzheimer's and Dementia2019454
34Association of Genomic O Island 122 of Escherichia coli EDL 933 with Verocytotoxin-Producing Escherichia coli Seropathotypes That Are Linked to Epidemic and/or Serious DiseaseJournal of Clinical Microbiology2003444
35Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1Neuron2003442
36New Onset Diabetes Mellitus in Patients Receiving Calcineurin Inhibitors: A Systematic Review and Meta-AnalysisAmerican Journal of Transplantation2004432
37PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast CancerCell Metabolism2015430
38Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case seriesAnnals of Oncology2018416
39Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategyActa Neuropathologica2016380
40CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumoursNature Communications2017379
41Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendationsActa Neuropathologica2009377
42CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancerBreast Cancer Research2012376
43Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanismsProceedings of the National Academy of Sciences of the United States of America2014373
44The shaping and functional consequences of the microRNA landscape in breast cancerNature2013370
45CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain TumorsClinical Cancer Research2019369
46β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatmentNature Medicine2007366
47Biocompatibility Testing of Branched and Linear PolyglycidolBiomacromolecules2006361
48Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profilingJournal of Pathology2013357
49Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic ProfilingScience Translational Medicine2012356
50Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancerNature Genetics2017356