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Top Articles

#TitleJournalYearCitations
1CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 ProductionJournal of Experimental Medicine19982,323
2CD4+CD25+ Immunoregulatory T CellsImmunity20021,297
3Stromal Cell Networks Regulate Lymphocyte Entry, Migration, and Territoriality in Lymph NodesImmunity2006869
4A2A adenosine receptor protects tumors from antitumor T cellsProceedings of the National Academy of Sciences of the United States of America2006837
5In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell AreasJournal of Experimental Medicine1997836
6Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell–dendritic cell interactionNature2006752
7Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph NodesScience2002678
8Autophagic programmed cell death by selective catalase degradationProceedings of the National Academy of Sciences of the United States of America2006619
9T-cell development and the CD4–CD8 lineage decisionNature Reviews Immunology2002611
10Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiencyNature Immunology2014575
11SAP-controlled T–B cell interactions underlie germinal centre formationNature2008548
12The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome ActivationCell2013536
13Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMsNature1990505
14Control of T-cell activation by CD4+ CD25+ suppressor T cellsImmunological Reviews2001499
15Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasisNature2009486
16Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory CellsJournal of Immunology2007449
17Stromal cell contributions to the homeostasis and functionality of the immune systemNature Reviews Immunology2009444
18Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T CellsJournal of Immunology2004443
19Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and ExpansionBlood1997434
20TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathwaysNature Immunology2003426
21An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune DiseaseJournal of Experimental Medicine1998425
22Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK ResponsesPLoS Biology2005420
23THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and CooperationAnnual Review of Immunology1999410
24MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen bindingNature1991392
25Primary Vitreoretinal Lymphoma: A Report from an International Primary Central Nervous System Lymphoma Collaborative Group SymposiumOncologist2011386
26Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing PathwaysJournal of Experimental Medicine2000372
27Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease PatientsJournal of Immunology2007368
28Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytesNature2002365
29MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8Nature1992358
30Intraocular LymphomaOphthalmology1993343
31COOPERATION BETWEEN CD4+AND CD8+T CELLS: When, Where, and HowAnnual Review of Immunology2006332
32Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial GranulomasImmunity2008324
33Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune DiseaseJournal of Immunology2002310
34Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein LevelsScience2008306
35Noncanonical Autophagy Promotes the Visual CycleCell2013303
36Dynamic imaging of the immune system: progress, pitfalls and promiseNature Reviews Immunology2006284
37Transforming growth factor β: a matter of life and deathJournal of Leukocyte Biology1994283
38A role for peptide in determining MHC class II structureNature1991276
39CARRIER FUNCTION IN ANTI-HAPTEN IMMUNE RESPONSESJournal of Experimental Medicine1970270
40Natural killer cell behavior in lymph nodes revealed by static and real-time imagingJournal of Experimental Medicine2006266
41IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune diseaseTrends in Immunology1996257
42The GITR–GITRL interaction: co-stimulation or contrasuppression of regulatory activity?Nature Reviews Immunology2006252
43Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3KJournal of Experimental Medicine2014249
44Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligandNature1999247
45GENETICS OF A NEW IgVH (T15 IDIOTYPE) MARKER IN THE MOUSE REGULATING NATURAL ANTIBODY TO PHOSPHORYLCHOLINEJournal of Experimental Medicine1974245
46ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugationNature Immunology2004245
47IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In VivoJournal of Immunology2011233
48Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial GranulomasImmunity2011226
49Expression of human β–hexosaminidase α–subunit gene (the gene defect of Tay–Sachs disease) in mouse brains upon engraftment of transduced progenitor cellsNature Medicine1996223
50T Helper Cell Differentiation, Heterogeneity, and PlasticityCold Spring Harbor Perspectives in Biology2018222