| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation | Journal of Experimental Medicine | 2000 | 4,394 |
| 3 | Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme | Cell | 2000 | 3,089 |
| 4 | Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 2,563 |
| 5 | PD-L2 is a second ligand for PD-1 and inhibits T cell activation | Nature Immunology | 2001 | 2,504 |
| 6 | Genetics of rheumatoid arthritis contributes to biology and drug discovery | Nature | 2014 | 1,974 |
| 7 | SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials | Lancet, The | 2019 | 1,958 |
| 8 | Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor | Immunity | 2009 | 1,955 |
| 9 | Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice | Science | 2001 | 1,613 |
| 10 | Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2) | Cell | 2000 | 1,489 |
| 11 | Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS) | Age and Ageing | 2014 | 1,462 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 13 | Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation | Developmental Cell | 2005 | 1,402 |
| 14 | NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells | Blood | 2002 | 1,322 |
| 15 | Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,308 |
| 16 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 1,294 |
| 17 | Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs | Cell Stem Cell | 2012 | 1,243 |
| 18 | Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus | Journal of Diabetes Investigation | 2010 | 1,206 |
| 19 | Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells | Cell | 2011 | 1,156 |
| 20 | Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse | Journal of Comparative Neurology | 2003 | 1,137 |
| 21 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics | Nature Medicine | 2001 | 1,113 |
| 22 | Oxidative stress and cancer: An overview | Ageing Research Reviews | 2013 | 1,106 |
| 23 | Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model | Journal of Experimental Medicine | 2007 | 1,064 |
| 24 | PD-1 and PD-1 ligands: from discovery to clinical application | International Immunology | 2007 | 1,064 |
| 25 | Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes | Developmental Cell | 2005 | 1,022 |
| 26 | Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis | Nature Neuroscience | 2008 | 1,015 |
| 27 | Identification of Tim4 as a phosphatidylserine receptor | Nature | 2007 | 985 |
| 28 | Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells | Science | 2008 | 967 |
| 29 | TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand | Journal of Experimental Medicine | 2005 | 952 |
| 30 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 947 |
| 31 | Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells1 | Biology of Reproduction | 2003 | 922 |
| 32 | Preparation and assessment of revised simulated body fluids | Journal of Biomedical Materials Research Part B | 2003 | 897 |
| 33 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties | Cell | 2013 | 889 |
| 34 | Dyspnea Is a Better Predictor of 5-Year Survival Than Airway Obstruction in Patients With COPD | Chest | 2002 | 847 |
| 35 | De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 | Annals of Oncology | 2017 | 844 |
| 36 | Dominant role of the niche in melanocyte stem-cell fate determination | Nature | 2002 | 825 |
| 37 | Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells | Cell | 2004 | 816 |
| 38 | Calcium-dependent phospholipid scrambling by TMEM16F | Nature | 2010 | 802 |
| 39 | The Many Roles of FAS Receptor Signaling in the Immune System | Immunity | 2009 | 800 |
| 40 | Inhibition of gastric inhibitory polypeptide signaling prevents obesity | Nature Medicine | 2002 | 798 |
| 41 | Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2 | Nature | 1999 | 788 |
| 42 | A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application | Nature Immunology | 2013 | 783 |
| 43 | Generation of Pluripotent Stem Cells from Neonatal Mouse Testis | Cell | 2004 | 766 |
| 44 | Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity | Nature | 2022 | 756 |
| 45 | Autoimmunity and the Clearance of Dead Cells | Cell | 2010 | 751 |
| 46 | PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 732 |
| 47 | Directed differentiation of telencephalic precursors from embryonic stem cells | Nature Neuroscience | 2005 | 727 |
| 48 | WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 1: Basic Principles and Terminology | Ultrasound in Medicine and Biology | 2015 | 718 |
| 49 | Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention | International Journal of Medical Sciences | 2014 | 717 |
| 50 | Subtypes of medulloblastoma have distinct developmental origins | Nature | 2010 | 710 |
