| # | Title | Journal | Year | Citations |
|---|
| 1 | Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion | Science | 2011 | 4,987 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Neurodegenerative diseases and oxidative stress | Nature Reviews Drug Discovery | 2004 | 2,923 |
| 4 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 2,165 |
| 5 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 1,898 |
| 6 | Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease | Annals of Neurology | 1999 | 1,721 |
| 7 | Natural Innate and Adaptive Immunity to Cancer | Annual Review of Immunology | 2011 | 1,691 |
| 8 | The neurobiology of zinc in health and disease | Nature Reviews Neuroscience | 2005 | 1,633 |
| 9 | Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice | Neuron | 2001 | 1,419 |
| 10 | Whole–genome characterization of chemoresistant ovarian cancer | Nature | 2015 | 1,206 |
| 11 | Adaptive immunity maintains occult cancer in an equilibrium state | Nature | 2007 | 1,204 |
| 12 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 13 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics | Nature Medicine | 2001 | 1,113 |
| 14 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 15 | γH2AX: a sensitive molecular marker of DNA damage and repair | Leukemia | 2010 | 1,078 |
| 16 | The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin | Nature Immunology | 2013 | 1,037 |
| 17 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 18 | SRST2: Rapid genomic surveillance for public health and hospital microbiology labs | Genome Medicine | 2014 | 953 |
| 19 | Multiple newly identified loci associated with prostate cancer susceptibility | Nature Genetics | 2008 | 796 |
| 20 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 764 |
| 21 | The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development | Cell Host and Microbe | 2015 | 721 |
| 22 | Distinct sites of intracellular production for Alzheimer's disease Aβ40/42 amyloid peptides | Nature Medicine | 1997 | 716 |
| 23 | Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis | Lancet Oncology, The | 2017 | 716 |
| 24 | Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss | Hepatology | 2004 | 687 |
| 25 | Cancer classification using the Immunoscore: a worldwide task force | Journal of Translational Medicine | 2012 | 676 |
| 26 | Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease | New England Journal of Medicine | 1989 | 654 |
| 27 | Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers | Hepatology | 2004 | 644 |
| 28 | Antithrombotic Therapy in Neonates and Children | Chest | 2008 | 602 |
| 29 | Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease | Cell | 2010 | 597 |
| 30 | Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo | Neuron | 2003 | 594 |
| 31 | Glucose transporter proteins in brain: Delivery of glucose to neurons and glia | Neuron | 1997 | 564 |
| 32 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 548 |
| 33 | Co-evolution of tumor cells and their microenvironment | Trends in Genetics | 2009 | 544 |
| 34 | Increased expression of the amyloid precursor ?-secretase in Alzheimer's disease | Annals of Neurology | 2002 | 540 |
| 35 | Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid | Journal of Biological Chemistry | 2002 | 536 |
| 36 | The redox chemistry of the Alzheimer's disease amyloid β peptide | Biochimica Et Biophysica Acta - Biomembranes | 2007 | 533 |
| 37 | Early evolution of the venom system in lizards and snakes | Nature | 2006 | 531 |
| 38 | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 | Nature Genetics | 2008 | 514 |
| 39 | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer | Nature Genetics | 2015 | 513 |
| 40 | Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion | Nature Medicine | 2011 | 511 |
| 41 | Perforin-mediated target-cell death and immune homeostasis | Nature Reviews Immunology | 2006 | 494 |
| 42 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 43 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array | Nature Genetics | 2013 | 492 |
| 44 | RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis | Cell | 2014 | 492 |
| 45 | Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export | Nature Medicine | 2012 | 491 |
| 46 | Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53 | Cancer Cell | 2012 | 468 |
| 47 | The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions | British Journal of Cancer | 2008 | 461 |
| 48 | Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion | Journal of Biological Chemistry | 1999 | 454 |
| 49 | The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth | Neuron | 1992 | 450 |
| 50 | Tau-mediated iron export prevents ferroptotic damage after ischemic stroke | Molecular Psychiatry | 2017 | 449 |
