| # | Title | Journal | Year | Citations |
|---|
| 1 | RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) | Nature | 2011 | 1,298 |
| 2 | Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner | Cell Stem Cell | 2011 | 653 |
| 3 | Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers | Angewandte Chemie - International Edition | 2011 | 576 |
| 4 | Comparative Analysis of Proteome and Transcriptome Variation in Mouse | PLoS Genetics | 2011 | 548 |
| 5 | Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions | Neuro-Oncology | 2020 | 543 |
| 6 | Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma | PLoS Medicine | 2008 | 499 |
| 7 | Anatomic Versus Physiologic Assessment of Coronary Artery Disease | Journal of the American College of Cardiology | 2013 | 495 |
| 8 | Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer | JAMA Oncology | 2019 | 493 |
| 9 | Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells | Genes and Development | 2011 | 488 |
| 10 | The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR | Nature | 2014 | 485 |
| 11 | CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer | Cancer Research | 2013 | 469 |
| 12 | Deficits in response inhibition associated with chronic methamphetamine abuse | Drug and Alcohol Dependence | 2005 | 361 |
| 13 | Imaging Tri-Fusion Multimodality Reporter Gene Expression in Living Subjects | Cancer Research | 2004 | 339 |
| 14 | 18F-fluciclovine PET-CT and 68Ga-PSMA-11 PET-CT in patients with early biochemical recurrence after prostatectomy: a prospective, single-centre, single-arm, comparative imaging trial | Lancet Oncology, The | 2019 | 338 |
| 15 | Nonlinear partial differential equations and applications: Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 331 |
| 16 | Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder | Neuropsychopharmacology | 1999 | 325 |
| 17 | Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease | American Journal of Pathology | 2012 | 321 |
| 18 | The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules | Immunity | 1997 | 320 |
| 19 | Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG | Journal of Nuclear Medicine | 2005 | 318 |
| 20 | Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy | Blood | 2010 | 316 |
| 21 | Inactivation of erythropoietin leads to defects in cardiac morphogenesis | Development (Cambridge) | 1999 | 299 |
| 22 | Withdrawal from Chronic Intermittent Ethanol Treatment Changes Subunit Composition, Reduces Synaptic Function, and Decreases Behavioral Responses to Positive Allosteric Modulators of GABAAReceptors | Molecular Pharmacology | 2003 | 298 |
| 23 | Effects of MAPK and PI3K Pathways on PD-L1 Expression in Melanoma | Clinical Cancer Research | 2014 | 294 |
| 24 | 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy | Journal of Nuclear Medicine | 2006 | 293 |
| 25 | Identification of a GABAA Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog | Journal of Neuroscience | 2006 | 280 |
| 26 | An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy | Cancer Research | 2016 | 265 |
| 27 | EANM procedure guidelines for radionuclide therapy with 177Lu-labelled PSMA-ligands (177Lu-PSMA-RLT) | European Journal of Nuclear Medicine and Molecular Imaging | 2019 | 265 |
| 28 | Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice | Nature Medicine | 1996 | 249 |
| 29 | Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy | Cancer Research | 2014 | 249 |
| 30 | Tetrahydrogestrinone: discovery, synthesis, and detection in urine | Rapid Communications in Mass Spectrometry | 2004 | 248 |
| 31 | Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a, and Atmospheric PM2.5Special Issue ofAerosol Science and Technologyon Findings from the Fine Particulate Matter Supersites Program | Aerosol Science and Technology | 2004 | 219 |
| 32 | Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage | Science | 2018 | 217 |
| 33 | NF-κB Inhibits Gammaherpesvirus Lytic Replication | Journal of Virology | 2003 | 214 |
| 34 | Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN | Cancer Cell | 2007 | 214 |
| 35 | Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans | Cell | 2020 | 211 |
| 36 | Histone Acetylation Regulates Intracellular pH | Molecular Cell | 2013 | 210 |
| 37 | Relationship between redox activity and chemical speciation of size-fractionated particulate matter | Particle and Fibre Toxicology | 2007 | 207 |
| 38 | Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes | ACS Nano | 2009 | 203 |
| 39 | Redox activity of urban quasi-ultrafine particles from primary and secondary sources | Atmospheric Environment | 2009 | 201 |
| 40 | Quantitative F18‐fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign | Cancer | 2010 | 200 |
| 41 | An Expanded Multilocus Sequence Typing Scheme for Propionibacterium acnes: Investigation of ‘Pathogenic’, ‘Commensal’ and Antibiotic Resistant Strains | PLoS ONE | 2012 | 196 |
| 42 | MicroRNA-21 targets the vitamin D–dependent antimicrobial pathway in leprosy | Nature Medicine | 2012 | 190 |
| 43 | 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling | Cell Metabolism | 2015 | 190 |
| 44 | E-PSMA: the EANM standardized reporting guidelines v1.0 for PSMA-PET | European Journal of Nuclear Medicine and Molecular Imaging | 2021 | 188 |
| 45 | The role of oxidative stress in adult critical care | Free Radical Biology and Medicine | 2006 | 186 |
| 46 | Reprograming of gut microbiome energy metabolism by the FUT2 Crohn’s disease risk polymorphism | ISME Journal | 2014 | 182 |
| 47 | Metabolic gatekeeper function of B-lymphoid transcription factors | Nature | 2017 | 175 |
| 48 | FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after the Initial Cycle of Neoadjuvant Chemotherapy in High-Grade Soft-Tissue Sarcomas | Clinical Cancer Research | 2009 | 172 |
| 49 | Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death | Molecular Systems Biology | 2012 | 168 |
| 50 | A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury | American Journal of Physiology - Heart and Circulatory Physiology | 2010 | 165 |
