| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family | Cell | 2012 | 1,413 |
| 2 | Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results | Blood | 2006 | 1,121 |
| 3 | The maternal-to-zygotic transition: a play in two acts | Development (Cambridge) | 2009 | 995 |
| 4 | The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 983 |
| 5 | Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms | Chemical Reviews | 2014 | 945 |
| 6 | Global analysis of protein phosphorylation in yeast | Nature | 2005 | 923 |
| 7 | Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party | Blood | 2018 | 833 |
| 8 | Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile | Cell | 2005 | 812 |
| 9 | Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex | Cell | 2005 | 724 |
| 10 | Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene | Nature Genetics | 2010 | 647 |
| 11 | Phosphoglucomutase Polymorphism in Man | Nature | 1964 | 638 |
| 12 | A measure of informed choice | Health Expectations | 2001 | 637 |
| 13 | Mapping Pathways and Phenotypes by Systematic Gene Overexpression | Molecular Cell | 2006 | 628 |
| 14 | The HUPO PSI's Molecular Interaction format—a community standard for the representation of protein interaction data | Nature Biotechnology | 2004 | 589 |
| 15 | A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains | Cell | 2014 | 574 |
| 16 | Exploration of Essential Gene Functions via Titratable Promoter Alleles | Cell | 2004 | 547 |
| 17 | A Snf2 Family ATPase Complex Required for Recruitment of the Histone H2A Variant Htz1 | Molecular Cell | 2003 | 527 |
| 18 | Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes | Nature Genetics | 2012 | 523 |
| 19 | Recognition of Bacteria in the Cytosol of Mammalian Cells by the Ubiquitin System | Current Biology | 2004 | 459 |
| 20 | Patient perspectives in the management of psoriasis: Results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey | Journal of the American Academy of Dermatology | 2014 | 447 |
| 21 | CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast | Cell | 2004 | 421 |
| 22 | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene ( LIPC ) | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 417 |
| 23 | Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 410 |
| 24 | Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria | New England Journal of Medicine | 2020 | 391 |
| 25 | Facile isolation and the characterization of human retinal stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 390 |
| 26 | Mutations of the TGF-β type II receptorBMPR2 in pulmonary arterial hypertension | Human Mutation | 2006 | 376 |
| 27 | Protein dynamics and conformational disorder in molecular recognition | Journal of Molecular Recognition | 2010 | 376 |
| 28 | Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis | Human Genetics | 2007 | 375 |
| 29 | Genetics and Genomics of Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2013 | 371 |
| 30 | Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA | Nature Genetics | 2008 | 370 |
| 31 | A Genetic Map of the Response to DNA Damage in Human Cells | Cell | 2020 | 370 |
| 32 | SH2 domains, interaction modules and cellular wiring | Trends in Cell Biology | 2001 | 364 |
| 33 | CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data | Genome Biology | 2016 | 360 |
| 34 | Naturally Occurring Off-Switches for CRISPR-Cas9 | Cell | 2016 | 357 |
| 35 | 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party | Blood | 2021 | 357 |
| 36 | High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes | Molecular Cell | 2004 | 347 |
| 37 | An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming | Cell | 2011 | 335 |
| 38 | Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 | Nature | 2010 | 326 |
| 39 | Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 312 |
| 40 | Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach | Human Molecular Genetics | 2004 | 304 |
| 41 | Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma | Human Molecular Genetics | 2008 | 302 |
| 42 | Observing biological dynamics at atomic resolution using NMR | Trends in Biochemical Sciences | 2009 | 298 |
| 43 | European consensus statement on phenotypes of pustular psoriasis | Journal of the European Academy of Dermatology and Venereology | 2017 | 297 |
| 44 | SMAUG Is a Major Regulator of Maternal mRNA Destabilization in Drosophila and Its Translation Is Activated by the PAN GU Kinase | Developmental Cell | 2007 | 287 |
| 45 | Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity | Immunity | 2007 | 283 |
| 46 | Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species | Nature Microbiology | 2016 | 276 |
| 47 | The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype | Nature Reviews Microbiology | 2008 | 273 |
| 48 | Towards a comprehensive structural variation map of an individual human genome | Genome Biology | 2010 | 272 |
| 49 | Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes | Nature Immunology | 2002 | 269 |
| 50 | Formation of Polyglutamine Inclusions in Non-CNS Tissue | Human Molecular Genetics | 1999 | 268 |
