| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 7,596 |
| 2 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit | Critical Care Medicine | 2013 | 3,144 |
| 3 | Lipid nanoparticles for mRNA delivery | Nature Reviews Materials | 2021 | 1,563 |
| 4 | MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,554 |
| 5 | Targeted drug delivery via the folate receptor | Advanced Drug Delivery Reviews | 2000 | 1,314 |
| 6 | Detection of microRNA Expression in Human Peripheral Blood Microvesicles | PLoS ONE | 2008 | 1,287 |
| 7 | The Chemistry of Neutron Capture Therapy | Chemical Reviews | 1998 | 1,144 |
| 8 | Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines | Gastroenterology | 2006 | 923 |
| 9 | Expression profiling identifies microRNA signature in pancreatic cancer | International Journal of Cancer | 2007 | 807 |
| 10 | Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo | Nature Biotechnology | 2016 | 754 |
| 11 | Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 | Blood | 2011 | 707 |
| 12 | Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes | Blood | 2013 | 682 |
| 13 | Cardiotoxicity of Chemotherapeutic Agents | Drug Safety | 2000 | 616 |
| 14 | Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation | Nature Medicine | 2001 | 601 |
| 15 | Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide) | Nature Biotechnology | 2000 | 563 |
| 16 | The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan | Journal of Experimental Medicine | 2003 | 555 |
| 17 | Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals | Blood | 2010 | 525 |
| 18 | Real-time PCR quantification of precursor and mature microRNA | Methods | 2008 | 520 |
| 19 | Drug discovery from natural sources | AAPS Journal | 2006 | 503 |
| 20 | Adult Burkitt leukemia and lymphoma | Blood | 2004 | 495 |
| 21 | Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells | Clinical Cancer Research | 2010 | 486 |
| 22 | Real-time expression profiling of microRNA precursors in human cancer cell lines | Nucleic Acids Research | 2005 | 483 |
| 23 | Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle* | Critical Care Medicine | 2014 | 452 |
| 24 | Antioxidant Xanthones from the Pericarp ofGarcinia mangostana(Mangosteen) | Journal of Agricultural and Food Chemistry | 2006 | 448 |
| 25 | Efficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine | Bioconjugate Chemistry | 2001 | 447 |
| 26 | Chemistry and Structural Biology of Androgen Receptor | Chemical Reviews | 2005 | 447 |
| 27 | Aromatase Inhibitors in the Treatment of Breast Cancer | Endocrine Reviews | 2005 | 436 |
| 28 | A high-throughput method to monitor the expression of microRNA precursors | Nucleic Acids Research | 2004 | 426 |
| 29 | Drug delivery and transport to solid tumors | Pharmaceutical Research | 2003 | 424 |
| 30 | The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery | Advanced Drug Delivery Reviews | 2016 | 424 |
| 31 | The Burden of Atopic Dermatitis: Impact on the Patient, Family, and Society | Pediatric Dermatology | 2005 | 423 |
| 32 | Regulation of the MIR155 host gene in physiological and pathological processes | Gene | 2013 | 421 |
| 33 | Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells | Journal of Extracellular Vesicles | 2017 | 404 |
| 34 | Hypertension-Linked Pathophysiological Alterations in the Gut | Circulation Research | 2017 | 402 |
| 35 | Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression | Nature Nanotechnology | 2018 | 387 |
| 36 | Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery | Colloids and Surfaces B: Biointerfaces | 2014 | 385 |
| 37 | MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer | Cancer Cell | 2009 | 381 |
| 38 | CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma | Leukemia | 2014 | 378 |
| 39 | Strategies, design, and chemistry in siRNA delivery systems | Advanced Drug Delivery Reviews | 2019 | 378 |
| 40 | Structural basis for antagonism and resistance of bicalutamide in prostate cancer | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 377 |
| 41 | A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia | Blood | 2004 | 372 |
| 42 | Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia | Blood | 2007 | 368 |
| 43 | The B-cell receptor signaling pathway as a therapeutic target in CLL | Blood | 2012 | 357 |
| 44 | Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors | Rna | 2008 | 353 |
| 45 | Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner | Cancer Research | 2013 | 352 |
| 46 | Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model | Pharmaceutical Research | 2006 | 351 |
| 47 | Preventability and severity assessment in reporting adverse drug reactions | American Journal of Health-System Pharmacy | 1992 | 348 |
| 48 | Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications | Analytical Biochemistry | 1991 | 332 |
| 49 | Costs and outcomes of acute kidney injury (AKI) following cardiac surgery | Nephrology Dialysis Transplantation | 2008 | 329 |
| 50 | Phase I Study of Decitabine Alone or in Combination With Valproic Acid in Acute Myeloid Leukemia | Journal of Clinical Oncology | 2007 | 326 |
