| # | Title | Journal | Year | Citations |
|---|
| 1 | Analyzing real-time PCR data by the comparative CT method | Nature Protocols | 2008 | 21,086 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,538 |
| 4 | Targeted drug delivery via the folate receptor | Advanced Drug Delivery Reviews | 2000 | 1,300 |
| 5 | Detection of microRNA Expression in Human Peripheral Blood Microvesicles | PLoS ONE | 2008 | 1,275 |
| 6 | Drug discovery from medicinal plants | Life Sciences | 2005 | 1,182 |
| 7 | The Chemistry of Neutron Capture Therapy | Chemical Reviews | 1998 | 1,130 |
| 8 | The Synthesis of Vicinal Amino Alcohols | Tetrahedron | 2000 | 838 |
| 9 | Expression profiling identifies microRNA signature in pancreatic cancer | International Journal of Cancer | 2006 | 800 |
| 10 | Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo | Nature Biotechnology | 2016 | 732 |
| 11 | Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 | Blood | 2011 | 689 |
| 12 | Ultraconserved Regions Encoding ncRNAs Are Altered in Human Leukemias and Carcinomas | Cancer Cell | 2007 | 681 |
| 13 | Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes | Blood | 2013 | 661 |
| 14 | Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation | Circulation | 2001 | 620 |
| 15 | Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation | Nature Medicine | 2001 | 593 |
| 16 | Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles | Journal of Controlled Release | 2009 | 564 |
| 17 | Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals | Blood | 2010 | 523 |
| 18 | Real-time PCR quantification of precursor and mature microRNA | Methods | 2008 | 512 |
| 19 | Drug discovery from natural sources | AAPS Journal | 2006 | 492 |
| 20 | Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival | Clinical Cancer Research | 2008 | 486 |
| 21 | Real-time expression profiling of microRNA precursors in human cancer cell lines | Nucleic Acids Research | 2005 | 480 |
| 22 | Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells | Clinical Cancer Research | 2010 | 478 |
| 23 | Ascorbate Attenuates Atrial Pacing-Induced Peroxynitrite Formation and Electrical Remodeling and Decreases the Incidence of Postoperative Atrial Fibrillation | Circulation Research | 2001 | 448 |
| 24 | Efficient Gene Transfer Using Reversibly Cross-Linked Low Molecular Weight Polyethylenimine | Bioconjugate Chemistry | 2001 | 444 |
| 25 | Chemistry and Structural Biology of Androgen Receptor | Chemical Reviews | 2005 | 439 |
| 26 | Antioxidant Xanthones from the Pericarp ofGarcinia mangostana(Mangosteen) | Journal of Agricultural and Food Chemistry | 2006 | 435 |
| 27 | Aromatase Inhibitors in the Treatment of Breast Cancer | Endocrine Reviews | 2005 | 431 |
| 28 | A high-throughput method to monitor the expression of microRNA precursors | Nucleic Acids Research | 2004 | 420 |
| 29 | Drug delivery and transport to solid tumors | Pharmaceutical Research | 2003 | 417 |
| 30 | MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer | Cancer Cell | 2009 | 377 |
| 31 | The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery | Advanced Drug Delivery Reviews | 2016 | 372 |
| 32 | Structural basis for antagonism and resistance of bicalutamide in prostate cancer | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 367 |
| 33 | Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia | Blood | 2007 | 367 |
| 34 | Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery | Colloids and Surfaces B: Biointerfaces | 2014 | 360 |
| 35 | Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells | Journal of Extracellular Vesicles | 2017 | 357 |
| 36 | Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression | Nature Nanotechnology | 2018 | 352 |
| 37 | Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors | Rna | 2008 | 351 |
| 38 | Evaluation of Combination Chemotherapy | Clinical Cancer Research | 2004 | 350 |
| 39 | The B-cell receptor signaling pathway as a therapeutic target in CLL | Blood | 2012 | 348 |
| 40 | Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model | Pharmaceutical Research | 2006 | 344 |
| 41 | A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells | Molecular Cancer Therapeutics | 2008 | 338 |
| 42 | Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications | Analytical Biochemistry | 1991 | 327 |
| 43 | Costs and outcomes of acute kidney injury (AKI) following cardiac surgery | Nephrology Dialysis Transplantation | 2008 | 327 |
| 44 | Recent Developments in the Maytansinoid Antitumor Agents | Chemical and Pharmaceutical Bulletin | 2004 | 310 |
| 45 | Multi-targeted therapy of cancer by niclosamide: A new application for an old drug | Cancer Letters | 2014 | 303 |
| 46 | The structural basis of camptothecin interactions with human serum albumin: impact on drug stability | Journal of Medicinal Chemistry | 1994 | 302 |
| 47 | Dexmedetomidine: An Updated Review | Annals of Pharmacotherapy | 2007 | 302 |
| 48 | Targeted drug delivery via folate receptors | Expert Opinion on Drug Delivery | 2008 | 296 |
| 49 | Receptor-targeted nanocarriers for therapeutic delivery to cancer | Molecular Membrane Biology | 2010 | 285 |
| 50 | Curcumin is a potent DNA hypomethylation agent | Bioorganic and Medicinal Chemistry Letters | 2009 | 284 |
