# | Title | Journal | Year | Citations |
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1 | Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2013 | 2,019 |
2 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,738 |
3 | Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence Instruments | AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | 2000 | 1,291 |
4 | Medullary Thyroid Cancer: Management Guidelines of the American Thyroid Association | Thyroid | 2009 | 1,247 |
5 | Management of a Solitary Thyroid Nodule | New England Journal of Medicine | 1993 | 1,238 |
6 | ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes | American Journal of Gastroenterology | 2015 | 1,204 |
7 | Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset | Blood | 2001 | 1,201 |
8 | Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture | Nature Genetics | 2012 | 1,100 |
9 | Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia | Journal of Experimental Medicine | 2001 | 978 |
10 | Activating ESR1 mutations in hormone-resistant metastatic breast cancer | Nature Genetics | 2013 | 925 |
11 | Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections | Nature Genetics | 2007 | 767 |
12 | CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity | Blood | 2003 | 750 |
13 | PTEN: One Gene, Many Syndromes | Human Mutation | 2003 | 729 |
14 | IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study | Journal of Clinical Oncology | 2010 | 699 |
15 | Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765 | Blood | 2011 | 689 |
16 | Functional abnormalities in isolated left bundle branch block. The effect of interventricular asynchrony. | Circulation | 1989 | 687 |
17 | Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes | Blood | 2013 | 661 |
18 | Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study | Journal of Clinical Oncology | 2006 | 618 |
19 | MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia | Blood | 2008 | 575 |
20 | Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing | Archives of General Psychiatry | 2005 | 556 |
21 | The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan | Journal of Experimental Medicine | 2003 | 537 |
22 | Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals | Blood | 2010 | 523 |
23 | Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC | Journal of Thoracic Oncology | 2018 | 515 |
24 | Phase II Trial of Sorafenib in Metastatic Thyroid Cancer | Journal of Clinical Oncology | 2009 | 513 |
25 | Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response | Journal of Immunology | 1999 | 509 |
26 | Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? | Blood | 2007 | 507 |
27 | S-glutathionylation uncouples eNOS and regulates its cellular and vascular function | Nature | 2010 | 507 |
28 | Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 498 |
29 | Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia | JAMA Oncology | 2015 | 498 |
30 | The Broad Spectrum of Human Natural Killer Cell Diversity | Immunity | 2017 | 485 |
31 | Will the real Cowden syndrome please stand up: revised diagnostic criteria | Journal of Medical Genetics | 2000 | 483 |
32 | Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells | Clinical Cancer Research | 2010 | 478 |
33 | Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response | Journal of Immunology | 1999 | 461 |
34 | Clinical proteomics: Written in blood | Nature | 2003 | 459 |
35 | The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis | Journal of Experimental Medicine | 2005 | 457 |
36 | Resistance to Antimicrobial Drugs—A Worldwide Calamity | Annals of Internal Medicine | 1993 | 450 |
37 | Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect | Blood | 2002 | 449 |
38 | Cardiac Mitochondria and Reactive Oxygen Species Generation | Circulation Research | 2014 | 449 |
39 | Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial | Lancet Oncology, The | 2014 | 438 |
40 | What does it take to make a natural killer? | Nature Reviews Immunology | 2003 | 437 |
41 | The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein | Cancer Cell | 2005 | 433 |
42 | Human natural killer cell development and biology | Blood Reviews | 2006 | 425 |
43 | Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs | Pharmacogenomics Journal | 2011 | 412 |
44 | Psychologic intervention improves survival for breast cancer patients | Cancer | 2008 | 408 |
45 | Human natural killer cell development | Immunological Reviews | 2006 | 405 |
46 | Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas | Nature Genetics | 2002 | 402 |
47 | Mutations in Regulatory Subunit Type 1A of Cyclic Adenosine 5′-Monophosphate-Dependent Protein Kinase (PRKAR1A): Phenotype Analysis in 353 Patients and 80 Different Genotypes | Journal of Clinical Endocrinology and Metabolism | 2009 | 399 |
48 | Association of Type and Location ofBRCA1andBRCA2Mutations With Risk of Breast and Ovarian Cancer | JAMA - Journal of the American Medical Association | 2015 | 390 |
49 | Clinical Genetic Testing for Familial Hypercholesterolemia | Journal of the American College of Cardiology | 2018 | 387 |
50 | Patient navigation: An update on the state of the science | Ca-A Cancer Journal for Clinicians | 2011 | 385 |