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Department of Pharmacology and Chemical Biology
›
top-articles
Department of Pharmacology and Chemical Biology
845
(top 1%)
papers
31.9K
(top 1%)
citations
83
(top 1%)
h
-index
136
(top 1%)
g
-index
911
all documents
35.3K
doc citations
3.8K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
1
Autophagy
2021
1,430
2
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis
Nature Medicine
2015
869
3
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Cell Reports
2017
608
4
Validating novel tau positron emission tomography tracer
[F‐18]‐AV‐1451 (T807)
on postmortem brain tissue
Annals of Neurology
2015
535
5
Chemical genetics of Plasmodium falciparum
Nature
2010
515
6
Sustained cyclic AMP production by parathyroid hormone receptor endocytosis
Nature Chemical Biology
2009
502
7
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance
Diabetes
2011
340
8
Neural Control of the Lower Urinary Tract
2015
337
9
Small Molecule Signaling Agents: The Integrated Chemistry and Biochemistry of Nitrogen Oxides, Oxides of Carbon, Dioxygen, Hydrogen Sulfide, and Their Derived Species
Chemical Research in Toxicology
2012
330
10
Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity
Science Translational Medicine
2011
328
11
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Science
2020
306
12
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Proceedings of the National Academy of Sciences of the United States of America
2017
285
13
A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis
Gastroenterology
2010
228
14
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Nature Chemical Biology
2009
221
15
Retromer terminates the generation of cAMP by internalized PTH receptors
Nature Chemical Biology
2011
205
16
PXR and CAR in energy metabolism
Trends in Endocrinology and Metabolism
2009
203
17
Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity
Cell
2019
202
18
Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47
Journal of Biological Chemistry
2010
199
19
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair
Nature
2011
190
20
Applications for α-lactalbumin in human nutrition
Nutrition Reviews
2018
186
21
Structure and dynamics of the active human parathyroid hormone receptor-1
Science
2019
185
22
Transduction of Redox Signaling by Electrophile-Protein Reactions
Science Signaling
2009
184
23
Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung Cancer
PLoS ONE
2010
183
24
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
Journal of Biological Chemistry
2011
182
25
PTH receptor-1 signalling—mechanistic insights and therapeutic prospects
Nature Reviews Endocrinology
2015
179
26
Quantitative PCR-Based Measurement of Nuclear and Mitochondrial DNA Damage and Repair in Mammalian Cells
Methods in Molecular Biology
2014
179
27
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
Biochimica Et Biophysica Acta - Molecular Basis of Disease
2011
177
28
Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
Nature Immunology
2020
172
29
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion
Cardiovascular Research
2010
171
30
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex
Cell
2020
167
31
Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production
Hepatology
2008
164
32
Alternative Lengthening of Telomeres and Loss of DAXX/ATRX Expression Predicts Metastatic Disease and Poor Survival in Patients with Pancreatic Neuroendocrine Tumors
Clinical Cancer Research
2017
164
33
Molecular recognition of nitrated fatty acids by PPARγ
Nature Structural and Molecular Biology
2008
161
34
Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z
PLoS ONE
2010
160
35
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP
Nature Communications
2014
158
36
Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR
Nature Communications
2015
156
37
Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids
Journal of Biological Chemistry
2010
151
38
Nrf2-dependent and -independent Responses to Nitro-fatty Acids in Human Endothelial Cells
Journal of Biological Chemistry
2009
150
39
Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease
Antioxidants and Redox Signaling
2013
150
40
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
Proceedings of the National Academy of Sciences of the United States of America
2018
150
41
Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease
Biochimica Et Biophysica Acta - Molecular Basis of Disease
2015
148
42
Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex
Proceedings of the National Academy of Sciences of the United States of America
2013
141
43
Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small-cell lung cancer
Oncogene
2019
140
44
Structural insights into the human D1 and D2 dopamine receptor signaling complexes
Cell
2021
140
45
Combined Analysis of Estrogen Receptor β-1 and Progesterone Receptor Expression Identifies Lung Cancer Patients with Poor Outcome
Clinical Cancer Research
2011
139
46
NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction
Cancer Research
2017
138
47
Following Cytochrome
c
Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1
Cancer Research
2011
134
48
Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair
Cancer Research
2011
134
49
A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology
Nature Cancer
2022
133
50
NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models
Proceedings of the National Academy of Sciences of the United States of America
2019
132
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