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Top Articles

#TitleJournalYearCitations
1The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and AntigenicityCell20201,362
2Structure of the RNA-dependent RNA polymerase from COVID-19 virusScience20201,228
3Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19JAMA - Journal of the American Medical Association20201,061
4Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivirScience2020950
5Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in VivoACS Nano2012724
6Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2PLoS Pathogens2018716
7Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinomaCell Research2019661
8The Arabidopsis CORONATINE INSENSITIVE1 Protein Is a Jasmonate Receptor  Plant Cell2009660
9Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4Cell Research2013588
10Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected PatientsClinical Infectious Diseases2020578
11NONCODE 2016: an informative and valuable data source of long non-coding RNAsNucleic Acids Research2016574
12The landscape of accessible chromatin in mammalian preimplantation embryosNature2016550
13Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor bindingCell Research2017547
14Frequency recognition based on canonical correlation analysis for SSVEP-based BCIsIEEE Transactions on Biomedical Engineering2007536
15A BCI-based environmental controller for the motion-disabledIEEE Transactions on Neural Systems and Rehabilitation Engineering2003524
16Frequency Recognition Based on Canonical Correlation Analysis for SSVEP-Based BCIsIEEE Transactions on Biomedical Engineering2006518
17Allelic reprogramming of the histone modification H3K4me3 in early mammalian developmentNature2016516
18Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infectionNature2016514
19Filter bank canonical correlation analysis for implementing a high-speed SSVEP-based brain–computer interfaceJournal of Neural Engineering2015481
20NONCODEV5: a comprehensive annotation database for long non-coding RNAsNucleic Acids Research2018434
21Parcellating cortical functional networks in individualsNature Neuroscience2015429
22Bridging Biological and Artificial Neural Networks with Emerging Neuromorphic Devices: Fundamentals, Progress, and ChallengesAdvanced Materials2019418
23Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent modelProceedings of the National Academy of Sciences of the United States of America2012407
24The hallmarks of cancer metabolism: Still emergingCell Metabolism2022386
25Structural insights into the mechanism of abscisic acid signaling by PYL proteinsNature Structural and Molecular Biology2009381
26A LINE1-Nucleolin Partnership Regulates Early Development and ESC IdentityCell2018381
27Structural Biology of the Major Facilitator Superfamily TransportersAnnual Review of Biophysics2015370
28Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9Proceedings of the National Academy of Sciences of the United States of America2013365
29Architecture of the mammalian mechanosensitive Piezo1 channelNature2015363
30Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent CellsCell Stem Cell2016358
31Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustionNature Immunology2021358
32Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapyCell Research2020349
33A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71Nature Structural and Molecular Biology2012347
34Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motilityNature2013338
35The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscapeNature2019338
36Self‐Fueled Biomimetic Liquid Metal MolluskAdvanced Materials2015336
37T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reactionNature2015333
38SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escapeCell2021332
39Structural advances for the major facilitator superfamily (MFS) transportersTrends in Biochemical Sciences2013329
40High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019Open Forum Infectious Diseases2020327
41Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoesNature2017318
42Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migrationCell Research2015307
43Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery diseaseNature Genetics2012295
44Liquid Metal CompositesMatter2020294
45Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3Nature2019292
46Evaluate the Malignancy of Pulmonary Nodules Using the 3-D Deep Leaky Noisy-OR NetworkIEEE Transactions on Neural Networks and Learning Systems2019288
47Combating COVID-19: health equity mattersNature Medicine2020285
48Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in DrosophilaCell Reports2014284
49Enhancement of Learning and Memory by Elevating Brain MagnesiumNeuron2010281
50The Role of NMDA Receptors in Alzheimer’s DiseaseFrontiers in Neuroscience2019275