| # | Title | Journal | Year | Citations |
|---|
| 1 | Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor | Nature | 2020 | 4,948 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 | Science | 2020 | 4,319 |
| 4 | Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death | Nature | 2015 | 4,072 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | A survey of best practices for RNA-seq data analysis | Genome Biology | 2016 | 1,898 |
| 7 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase | Cell Research | 2014 | 1,719 |
| 8 | Human neutralizing antibodies elicited by SARS-CoV-2 infection | Nature | 2020 | 1,524 |
| 9 | Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function | Genomics, Proteomics and Bioinformatics | 2015 | 1,466 |
| 10 | Chromatin architecture reorganization during stem cell differentiation | Nature | 2015 | 1,442 |
| 11 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 12 | Serine/Threonine Phosphatases: Mechanism through Structure | Cell | 2009 | 1,292 |
| 13 | A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 | Science | 2020 | 1,292 |
| 14 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus | Science | 2020 | 1,228 |
| 15 | Autophagy pathway: Cellular and molecular mechanisms | Autophagy | 2018 | 984 |
| 16 | Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals | Immunity | 2020 | 979 |
| 17 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis | Cell Research | 2014 | 869 |
| 18 | Molecular Architecture of the SARS-CoV-2 Virus | Cell | 2020 | 793 |
| 19 | Cellular Internalization of Exosomes Occurs Through Phagocytosis | Traffic | 2010 | 757 |
| 20 | The Jasmonate-ZIM-Domain Proteins Interact with the WD-Repeat/bHLH/MYB Complexes to Regulate Jasmonate-Mediated Anthocyanin Accumulation and Trichome Initiation inArabidopsis thaliana | Plant Cell | 2011 | 743 |
| 21 | Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 | PLoS Pathogens | 2018 | 716 |
| 22 | Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells | Science | 2020 | 716 |
| 23 | Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism | Nature | 2016 | 648 |
| 24 | PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis | Cell | 2012 | 635 |
| 25 | Structural Basis for flg22-Induced Activation of the Arabidopsis FLS2-BAK1 Immune Complex | Science | 2013 | 604 |
| 26 | The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme | Molecular and Cellular Proteomics | 2011 | 598 |
| 27 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 | Cell Research | 2013 | 588 |
| 28 | Inhalable Microorganisms in Beijing’s PM2.5 and PM10 Pollutants during a Severe Smog Event | Environmental Science & Technology | 2014 | 578 |
| 29 | TGF-β Signaling from Receptors to Smads | Cold Spring Harbor Perspectives in Biology | 2016 | 578 |
| 30 | Sampling the conformational space of the catalytic subunit of human γ-secretase | ELife | 2015 | 556 |
| 31 | Reconstitution and structure of a plant NLR resistosome conferring immunity | Science | 2019 | 551 |
| 32 | The landscape of accessible chromatin in mammalian preimplantation embryos | Nature | 2016 | 550 |
| 33 | Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding | Cell Research | 2017 | 547 |
| 34 | Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects | Cell Stem Cell | 2015 | 545 |
| 35 | Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment | ACS Nano | 2011 | 543 |
| 36 | Chitin-Induced Dimerization Activates a Plant Immune Receptor | Science | 2012 | 534 |
| 37 | Allelic reprogramming of the histone modification H3K4me3 in early mammalian development | Nature | 2016 | 516 |
| 38 | Single-cell landscape of immunological responses in patients with COVID-19 | Nature Immunology | 2020 | 508 |
| 39 | The Jasmonate-ZIM Domain Proteins Interact with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Affect Jasmonate-Regulated Stamen Development in Arabidopsis | Plant Cell | 2011 | 502 |
| 40 | An atomic structure of human γ-secretase | Nature | 2015 | 490 |
| 41 | The Mg-Chelatase H Subunit ofArabidopsisAntagonizes a Group of WRKY Transcription Repressors to Relieve ABA-Responsive Genes of Inhibition | Plant Cell | 2010 | 475 |
| 42 | Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder | Nature | 2015 | 461 |
| 43 | MicroRNAs and Their Regulatory Roles in Plant–Environment Interactions | Annual Review of Plant Biology | 2019 | 454 |
| 44 | The role of 3D genome organization in development and cell differentiation | Nature Reviews Molecular Cell Biology | 2019 | 451 |
| 45 | ULK 1 translocates to mitochondria and phosphorylates FUNDC 1 to regulate mitophagy | EMBO Reports | 2014 | 435 |
| 46 | Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 431 |
| 47 | 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis | Cell | 2017 | 415 |
| 48 | The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism | Cell Metabolism | 2014 | 406 |
| 49 | Allelic reprogramming of 3D chromatin architecture during early mammalian development | Nature | 2017 | 406 |
| 50 | DWARF14 is a non-canonical hormone receptor for strigolactone | Nature | 2016 | 399 |
