| # | Title | Journal | Year | Citations |
|---|
| 1 | Visualization and analysis of gene expression in tissue sections by spatial transcriptomics | Science | 2016 | 1,983 |
| 2 | Dynamics of fat cell turnover in humans | Nature | 2008 | 1,914 |
| 3 | Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System | Cell | 1999 | 1,785 |
| 4 | Dynamics of Hippocampal Neurogenesis in Adult Humans | Cell | 2013 | 1,523 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | A molecular atlas of cell types and zonation in the brain vasculature | Nature | 2018 | 1,310 |
| 7 | The Norway spruce genome sequence and conifer genome evolution | Nature | 2013 | 1,303 |
| 8 | Notch signalling controls pancreatic cell differentiation | Nature | 1999 | 1,075 |
| 9 | Generalized Potential of Adult Neural Stem Cells | Science | 2000 | 978 |
| 10 | Dynamics of Cell Generation and Turnover in the Human Heart | Cell | 2015 | 923 |
| 11 | Notch signaling: simplicity in design, versatility in function | Development (Cambridge) | 2011 | 823 |
| 12 | Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 816 |
| 13 | Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension | Science | 2007 | 804 |
| 14 | Neurogenesis in the Striatum of the Adult Human Brain | Cell | 2014 | 786 |
| 15 | An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data | PLoS Computational Biology | 2009 | 777 |
| 16 | Spinal Cord Repair in Adult Paraplegic Rats: Partial Restoration of Hind Limb Function | Science | 1996 | 744 |
| 17 | A Pericyte Origin of Spinal Cord Scar Tissue | Science | 2011 | 711 |
| 18 | Vertebrate neurogenesis is counteracted by Sox1–3 activity | Nature Neuroscience | 2003 | 708 |
| 19 | High-definition spatial transcriptomics for in situ tissue profiling | Nature Methods | 2019 | 708 |
| 20 | Notch Signaling in Development, Tissue Homeostasis, and Disease | Physiological Reviews | 2017 | 658 |
| 21 | The Murine SCP3 Gene Is Required for Synaptonemal Complex Assembly, Chromosome Synapsis, and Male Fertility | Molecular Cell | 2000 | 641 |
| 22 | Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype | Cancer Cell | 2006 | 624 |
| 23 | Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression | Nature | 2001 | 609 |
| 24 | Human Adult Neurogenesis: Evidence and Remaining Questions | Cell Stem Cell | 2018 | 601 |
| 25 | A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition | Nature Cell Biology | 2009 | 585 |
| 26 | Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease | Nature Communications | 2018 | 584 |
| 27 | Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome | Nature Neuroscience | 2005 | 582 |
| 28 | DNA rendering of polyhedral meshes at the nanoscale | Nature | 2015 | 576 |
| 29 | Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha | EMBO Journal | 1998 | 563 |
| 30 | Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells | PLoS Biology | 2008 | 558 |
| 31 | Identification of Intrinsic Determinants of Midbrain Dopamine Neurons | Cell | 2006 | 549 |
| 32 | Origin of New Glial Cells in Intact and Injured Adult Spinal Cord | Cell Stem Cell | 2010 | 533 |
| 33 | Retrospective Birth Dating of Cells in Humans | Cell | 2005 | 522 |
| 34 | Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300 | EMBO Journal | 1999 | 509 |
| 35 | Identification of tissue-specific cell death using methylation patterns of circulating DNA | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 492 |
| 36 | A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. | Genes and Development | 1995 | 491 |
| 37 | Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology | Diabetes | 2010 | 490 |
| 38 | Specification of neuronal fates in the ventral neural tube | Current Opinion in Neurobiology | 2001 | 482 |
| 39 | Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq | Nature Biotechnology | 2016 | 478 |
| 40 | Postreplicative Recruitment of Cohesin to Double-Strand Breaks Is Required for DNA Repair | Molecular Cell | 2004 | 473 |
| 41 | Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system | Developmental Brain Research | 1995 | 453 |
| 42 | Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1 | EMBO Journal | 1998 | 450 |
| 43 | Genetic Analysis of Ephrin-A2 and Ephrin-A5 Shows Their Requirement in Multiple Aspects of Retinocollicular Mapping | Neuron | 2000 | 450 |
| 44 | Inhibition of proteasome deubiquitinating activity as a new cancer therapy | Nature Medicine | 2011 | 431 |
| 45 | Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke | Nature Neuroscience | 2009 | 415 |
| 46 | Therapeutic modulation of Notch signalling — are we there yet? | Nature Reviews Drug Discovery | 2014 | 413 |
| 47 | Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 404 |
| 48 | Genomic encoding of transcriptional burst kinetics | Nature | 2019 | 403 |
| 49 | A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α | Brain | 2010 | 401 |
| 50 | Neocortical neurogenesis in humans is restricted to development | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 399 |
