| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein | Cell | 2020 | 7,339 |
| 2 | A robust and high-throughput Cre reporting and characterization system for the whole mouse brain | Nature Neuroscience | 2010 | 5,988 |
| 3 | Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor | Science | 2000 | 5,516 |
| 4 | Quantitative analysis of complex protein mixtures using isotope-coded affinity tags | Nature Biotechnology | 1999 | 4,687 |
| 5 | Skyline: an open source document editor for creating and analyzing targeted proteomics experiments | Bioinformatics | 2010 | 4,162 |
| 6 | Accurate prediction of protein structures and interactions using a three-track neural network | Science | 2021 | 3,363 |
| 7 | The MAPK signaling cascade | FASEB Journal | 1995 | 3,225 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 9 | Direct analysis of protein complexes using mass spectrometry | Nature Biotechnology | 1999 | 2,206 |
| 10 | Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding | Cell | 2020 | 1,821 |
| 11 | Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody | Nature | 2020 | 1,778 |
| 12 | The coagulation cascade: initiation, maintenance, and regulation | Biochemistry | 1991 | 1,752 |
| 13 | Protein structure prediction and analysis using the Robetta server | Nucleic Acids Research | 2004 | 1,747 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,642 |
| 15 | MAP Kinases in the Immune Response | Annual Review of Immunology | 2002 | 1,536 |
| 16 | Leptin-regulated endocannabinoids are involved in maintaining food intake | Nature | 2001 | 1,482 |
| 17 | Protein Structure Prediction Using Rosetta | Methods in Enzymology | 2004 | 1,472 |
| 18 | Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis | Cell | 2005 | 1,471 |
| 19 | Contact order, transition state placement and the refolding rates of single domain proteins 1 1Edited by P. E. Wright | Journal of Molecular Biology | 1998 | 1,467 |
| 20 | Comparing Photosynthetic and Photovoltaic Efficiencies and Recognizing the Potential for Improvement | Science | 2011 | 1,418 |
| 21 | Quantitative reactivity profiling predicts functional cysteines in proteomes | Nature | 2010 | 1,416 |
| 22 | Identification and Functional Characterization of Brainstem Cannabinoid CB 2 Receptors | Science | 2005 | 1,370 |
| 23 | Inflammation as a Risk Factor for Atrial Fibrillation | Circulation | 2003 | 1,315 |
| 24 | Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes | Nature | 1982 | 1,282 |
| 25 | Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and bayesian scoring functions | Journal of Molecular Biology | 1997 | 1,279 |
| 26 | Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology | Cell | 2020 | 1,268 |
| 27 | Improved protein structure prediction using predicted interresidue orientations | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 1,201 |
| 28 | Optimal description of a protein structure in terms of multiple groups undergoing TLS motion | Acta Crystallographica Section D: Biological Crystallography | 2006 | 1,187 |
| 29 | Improving physical realism, stereochemistry, and side‐chain accuracy in homology modeling: Four approaches that performed well in CASP8 | Proteins: Structure, Function and Bioinformatics | 2009 | 1,167 |
| 30 | Kemp elimination catalysts by computational enzyme design | Nature | 2008 | 1,148 |
| 31 | The coming of age of de novo protein design | Nature | 2016 | 1,141 |
| 32 | The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design | Journal of Chemical Theory and Computation | 2017 | 1,117 |
| 33 | RNA-binding proteins: modular design for efficient function | Nature Reviews Molecular Cell Biology | 2007 | 1,095 |
| 34 | Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase | Nature | 1990 | 1,090 |
| 35 | Predicting protein structures with a multiplayer online game | Nature | 2010 | 1,085 |
| 36 | The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. | Genes and Development | 1996 | 1,057 |
| 37 | High-Resolution Comparative Modeling with RosettaCM | Structure | 2013 | 1,051 |
| 38 | Protein–Protein Docking with Simultaneous Optimization of Rigid-body Displacement and Side-chain Conformations | Journal of Molecular Biology | 2003 | 1,041 |
| 39 | Production of transgenic rabbits, sheep and pigs by microinjection | Nature | 1985 | 988 |
| 40 | NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates | Science | 2005 | 985 |
| 41 | Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y | Nature | 1996 | 981 |
| 42 | Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift | Nature | 2022 | 977 |
| 43 | Multiple Forms of DNA-dependent RNA Polymerase in Eukaryotic Organisms | Nature | 1969 | 928 |
| 44 | TriTrypDB: a functional genomic resource for the Trypanosomatidae | Nucleic Acids Research | 2010 | 879 |
| 45 | Detection of ultra-rare mutations by next-generation sequencing | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 877 |
| 46 | Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 | EMBO Journal | 1997 | 869 |
| 47 | A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria | Cell Host and Microbe | 2010 | 860 |
| 48 | Matricellular proteins: extracellular modulators of cell function | Current Opinion in Cell Biology | 2002 | 859 |
| 49 | Macromolecular Modeling with Rosetta | Annual Review of Biochemistry | 2008 | 852 |
| 50 | Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA | Science | 1998 | 849 |
