# | Title | Journal | Year | Citations |
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1 | Crystal structure of the β2 adrenergic receptor–Gs protein complex | Nature | 2011 | 2,712 |
2 | Structure of a nanobody-stabilized active state of the β2 adrenoceptor | Nature | 2011 | 1,523 |
3 | Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones* | Endocrine Reviews | 1997 | 1,320 |
4 | Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery | Experimental Biology and Medicine | 2003 | 1,310 |
5 | Crystal structure of the µ-opioid receptor bound to a morphinan antagonist | Nature | 2012 | 1,202 |
6 | HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor | Molecular Cell | 2005 | 1,007 |
7 | Structure and function of an irreversible agonist-β2 adrenoceptor complex | Nature | 2011 | 741 |
8 | Conformational biosensors reveal GPCR signalling from endosomes | Nature | 2013 | 713 |
9 | Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development | Cell | 2011 | 685 |
10 | Hepatic toxicity resulting from cancer treatment | International Journal of Radiation Oncology Biology Physics | 1995 | 639 |
11 | Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion. | Journal of Clinical Investigation | 1988 | 624 |
12 | Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities | Journal of Lipid Research | 2005 | 607 |
13 | A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 593 |
14 | The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. | Journal of Biological Chemistry | 1993 | 567 |
15 | Myocardial protection with preconditioning. | Circulation | 1990 | 446 |
16 | PTEN and Myotubularin: Novel Phosphoinositide Phosphatases | Annual Review of Biochemistry | 2001 | 440 |
17 | The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor | Journal of Biological Chemistry | 1993 | 438 |
18 | Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities | Drug Metabolism and Disposition | 1991 | 427 |
19 | Phagocyte-derived catecholamines enhance acute inflammatory injury | Nature | 2007 | 396 |
20 | Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor | Journal of Biological Chemistry | 1989 | 367 |
21 | Benzodiazepines: use, abuse, and consequences | Pharmacological Reviews | 1992 | 350 |
22 | Conformational changes in the G protein Gs induced by the β2 adrenergic receptor | Nature | 2011 | 339 |
23 | Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment | Science | 1978 | 326 |
24 | Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1 | Neuron | 2006 | 324 |
25 | α-Latrotoxin Stimulates Exocytosis by the Interaction with a Neuronal G-Protein-Coupled Receptor | Neuron | 1997 | 323 |
26 | Behavioral variables affecting the development of amphetamine tolerance | Psychopharmacology | 1966 | 293 |
27 | Human Serum Paraoxonase/Arylesterase’s Retained HydrophobicN-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids | Arteriosclerosis, Thrombosis, and Vascular Biology | 1999 | 290 |
28 | Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells | Journal of Biological Chemistry | 1998 | 287 |
29 | Mechanisms of myocardial reperfusion injury | Annals of Thoracic Surgery | 1999 | 285 |
30 | Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor | Journal of Biological Chemistry | 1989 | 276 |
31 | The [35S]GTPγS binding assay: approaches and applications in pharmacology | Life Sciences | 2003 | 268 |
32 | Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement | Cellular Signalling | 2004 | 267 |
33 | Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and RanGTP | Nature Cell Biology | 2010 | 260 |
34 | The principles of directed cell migration | Nature Reviews Molecular Cell Biology | 2021 | 252 |
35 | Structural basis for nucleotide exchange in heterotrimeric G proteins | Science | 2015 | 250 |
36 | Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice | Circulation Research | 2005 | 238 |
37 | Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system | Journal of Biological Chemistry | 1993 | 237 |
38 | Intracellular Ca2+ activates phospholipase C | Trends in Neurosciences | 1988 | 235 |
39 | Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery | Journal of Biological Chemistry | 1997 | 235 |
40 | Allosteric coupling from G protein to the agonist-binding pocket in GPCRs | Nature | 2016 | 235 |
41 | Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation | Nature Neuroscience | 2008 | 233 |
42 | Efficient Coupling of Transducin to Monomeric Rhodopsin in a Phospholipid Bilayer | Journal of Biological Chemistry | 2008 | 233 |
43 | Abuse Liability of Flunitrazepam | Journal of Clinical Psychopharmacology | 1997 | 232 |
44 | Functional Vitamin D Receptor (VDR) in the T-Tubules of Cardiac Myocytes: VDR Knockout Cardiomyocyte Contractility | Endocrinology | 2008 | 228 |
45 | Abuse liability of benzodiazepines | Pharmacological Reviews | 1987 | 227 |
46 | Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP | Biochemical Journal | 1990 | 223 |
47 | Assembly of GABAA receptor subunits: alpha 1 beta 1 and alpha 1 beta 1 gamma 2S subunits produce unique ion channels with dissimilar single- channel properties | Journal of Neuroscience | 1993 | 222 |
48 | The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 218 |
49 | The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins | Biochemistry | 1990 | 217 |
50 | Relationship Between Ca2+Uptake and Catecholamine Secretion in Primary Dissociated Cultures of Adrenal Medulla | Journal of Neurochemistry | 1982 | 207 |