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Top Articles

#TitleJournalYearCitations
1TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cellsNature20183,359
2Visualization and analysis of gene expression in tissue sections by spatial transcriptomicsScience20161,983
3Landscape of somatic mutations in 560 breast cancer whole-genome sequencesNature20161,760
4Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteriaMovement Disorders20171,402
5Tertiary lymphoid structures improve immunotherapy and survival in melanomaNature20201,209
6HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signaturesNature Medicine2017769
7A Consensus Molecular Classification of Muscle-invasive Bladder CancerEuropean Urology2020741
8High-definition spatial transcriptomics for in situ tissue profilingNature Methods2019708
9Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencingNature Communications2018496
10Comprehensive Transcriptional Analysis of Early-Stage Urothelial CarcinomaCancer Cell2016486
11An integrated expression atlas of miRNAs and their promoters in human and mouseNature Biotechnology2017456
12An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor ProgressionCancer Cell2017352
13Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem CellsCell2018332
14Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanomaNature Communications2017310
15Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 FamiliesJournal of Clinical Oncology2020270
16Molecular classification of urothelial carcinoma: global mRNA classification versus tumour‐cell phenotype classificationJournal of Pathology2017258
17Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer ProgramAnnals of Oncology2018246
18The topography of mutational processes in breast cancer genomesNature Communications2016235
19Pervasive chromosomal instability and karyotype order in tumour evolutionNature2020221
20Whole-genome sequencing of triple-negative breast cancers in a population-based clinical studyNature Medicine2019218
21Quantification of microscopic diffusion anisotropy disentangles effects of orientation dispersion from microstructure: Applications in healthy volunteers and in brain tumorsNeuroImage2015216
22Integrating spatial gene expression and breast tumour morphology via deep learningNature Biomedical Engineering2020208
23An international study to increase concordance in Ki67 scoringModern Pathology2015195
24Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas DatasetEuropean Urology2017195
25Prognostic impact of tumour‐infiltrating B cells and plasma cells in colorectal cancerInternational Journal of Cancer2016192
26Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s diseaseActa Neuropathologica2019187
27Bladder Cancer Molecular Taxonomy: Summary from a Consensus MeetingBladder Cancer2016184
28MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitmentNature Communications2015175
29Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC scoreBMC Medicine2021164
30An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancerNature Communications2021159
31Apolipoproteins, lipids and risk of cancerInternational Journal of Cancer2016156
3218F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriersBrain2016149
33Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapyOncotarget2015148
34Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancerScientific Reports2016143
35The Immune Landscape of Prostate Cancer and Nomination of PD-L2 as a Potential Therapeutic TargetJournal of the National Cancer Institute2019142
36The link between diffusion MRI and tumor heterogeneity: Mapping cell eccentricity and density by diffusional variance decomposition (DIVIDE)NeuroImage2016141
37The FLASH effect depends on oxygen concentrationBritish Journal of Radiology2020133
38An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironmentNature Communications2019132
39The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routineGenome Medicine2015129
40A validation and extended description of the Lund taxonomy for urothelial carcinoma using the TCGA cohortScientific Reports2018128
41Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11Lung Cancer2019127
42Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohortBMC Cancer2016125
43Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggressionNature Materials2021125
44Which ante mortem clinical features predict progressive supranuclear palsy pathology?Movement Disorders2017121
45Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signalingNature Medicine2018120
46Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltrationNature Communications2016119
47Criminal Behavior in Frontotemporal Dementia and Alzheimer DiseaseJAMA Neurology2015113
48NF1‐mutated melanoma tumors harbor distinct clinical and biological characteristicsMolecular Oncology2017112
49Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaborationNpj Breast Cancer2016109
50Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51DJournal of the National Cancer Institute2020106