| # | Title | Journal | Year | Citations |
|---|
| 1 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 2 | Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention | Nature Reviews Gastroenterology and Hepatology | 2021 | 867 |
| 3 | DNA methylation-based measures of biological age: meta-analysis predicting time to death | Aging | 2016 | 786 |
| 4 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 5 | Systematic review of the Exploration, Preparation, Implementation, Sustainment (EPIS) framework | Implementation Science | 2019 | 635 |
| 6 | Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease | Nature | 2019 | 493 |
| 7 | Peripheral artery disease: epidemiology and global perspectives | Nature Reviews Cardiology | 2017 | 470 |
| 8 | American Cancer Society guideline for diet and physical activity for cancer prevention | Ca-A Cancer Journal for Clinicians | 2020 | 362 |
| 9 | Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization | Npj Genomic Medicine | 2018 | 314 |
| 10 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction | Nature Genetics | 2021 | 264 |
| 11 | Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood | ACS Nano | 2018 | 224 |
| 12 | Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women | JAMA - Journal of the American Medical Association | 2017 | 216 |
| 13 | Telemedicine-delivered treatment interventions for substance use disorders: A systematic review | Journal of Substance Abuse Treatment | 2019 | 185 |
| 14 | Participation of people living with disabilities in physical activity: a global perspective | Lancet, The | 2021 | 183 |
| 15 | Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014 | Alzheimer's and Dementia | 2015 | 181 |
| 16 | Evolutionary Pressure against MHC Class II Binding Cancer Mutations | Cell | 2018 | 176 |
| 17 | International comparisons of the associations between objective measures of the built environment and transport-related walking and cycling: IPEN adult study | Journal of Transport and Health | 2016 | 160 |
| 18 | Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers | JAMA Psychiatry | 2016 | 158 |
| 19 | Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis | Hepatology | 2020 | 151 |
| 20 | Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study | Lancet Neurology, The | 2019 | 150 |
| 21 | The sex-specific association between BMI and coronary heart disease: a systematic review and meta-analysis of 95 cohorts with 1·2 million participants | Lancet Diabetes and Endocrinology,the | 2015 | 146 |
| 22 | Sedentary Behavior and Cardiovascular Disease in Older Women | Circulation | 2019 | 146 |
| 23 | Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index | European Heart Journal | 2019 | 144 |
| 24 | Technology to Support Aging in Place: Older Adults’ Perspectives | Healthcare (Switzerland) | 2019 | 144 |
| 25 | Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen | Journal of the American Society of Nephrology: JASN | 2019 | 135 |
| 26 | Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients | American Journal of Cardiology | 2020 | 134 |
| 27 | Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms | JAMA Internal Medicine | 2018 | 133 |
| 28 | Self-efficacy versus perceived enjoyment as predictors of physical activity behaviour | Psychology and Health | 2016 | 129 |
| 29 | B Vitamins and Their Role in Immune Regulation and Cancer | Nutrients | 2020 | 129 |
| 30 | Access to parks and physical activity: An eight country comparison | Urban Forestry and Urban Greening | 2017 | 125 |
| 31 | Pre-clinical remote undergraduate medical education during the COVID-19 pandemic: a survey study | BMC Medical Education | 2021 | 125 |
| 32 | Physicians’ Well-Being Linked To In-Basket Messages Generated By Algorithms In Electronic Health Records | Health Affairs | 2019 | 123 |
| 33 | Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults | PLoS ONE | 2017 | 120 |
| 34 | The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease | Journal of Hepatology | 2020 | 119 |
| 35 | Machine Learning to Detect Self-Reporting of Symptoms, Testing Access, and Recovery Associated With COVID-19 on Twitter: Retrospective Big Data Infoveillance Study | JMIR Public Health and Surveillance | 2020 | 119 |
| 36 | Randomized controlled trial of increasing physical activity on objectively measured and self‐reported cognitive functioning among breast cancer survivors: The memory & motion study | Cancer | 2018 | 118 |
| 37 | Building the case for actionable ethics in digital health research supported by artificial intelligence | BMC Medicine | 2019 | 118 |
| 38 | Obstructive sleep apnea and longitudinal Alzheimer’s disease biomarker changes | Sleep | 2019 | 113 |
| 39 | Telephone-Based Cognitive Behavioral Therapy for Insomnia in Perimenopausal and Postmenopausal Women With Vasomotor Symptoms | JAMA Internal Medicine | 2016 | 110 |
| 40 | Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study | NeuroImage | 2019 | 109 |
| 41 | Discovery of shared genomic loci using the conditional false discovery rate approach | Human Genetics | 2020 | 109 |
| 42 | Towards better evidence-informed global action: lessons learnt from the Lancet series and recent developments in physical activity and public health | British Journal of Sports Medicine | 2020 | 108 |
| 43 | The economic burden of physical inactivity: a systematic review and critical appraisal | British Journal of Sports Medicine | 2017 | 107 |
| 44 | Strength of obesity prevention interventions in early care and education settings: A systematic review | Preventive Medicine | 2017 | 106 |
| 45 | Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease | Gastroenterology | 2020 | 103 |
| 46 | Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment | Birth Defects Research | 2017 | 101 |
| 47 | Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium | PLoS Genetics | 2017 | 98 |
| 48 | Patterns of Fitbit Use and Activity Levels Throughout a Physical Activity Intervention: Exploratory Analysis from a Randomized Controlled Trial | JMIR MHealth and UHealth | 2018 | 98 |
| 49 | Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome | MSystems | 2018 | 96 |
| 50 | Serum 25-Hydroxyvitamin D Concentrations ≥40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study | PLoS ONE | 2016 | 96 |
