| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Evolving importance of kidney disease: from subspecialty to global health burden | Lancet, The | 2013 | 874 |
| 4 | Integration of Oxygen Signaling at the Consensus HRE | Science Signaling | 2005 | 788 |
| 5 | Genome-wide association analyses identify 18 new loci associated with serum urate concentrations | Nature Genetics | 2013 | 675 |
| 6 | CATs and HATs: the SLC7 family of amino acid transporters | Pflugers Archiv European Journal of Physiology | 2004 | 587 |
| 7 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 8 | Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism | Science | 2006 | 512 |
| 9 | Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family | Nature | 1998 | 508 |
| 10 | HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration | Nature Medicine | 2002 | 490 |
| 11 | Induction of HIF–1α in response to hypoxia is instantaneous | FASEB Journal | 2001 | 470 |
| 12 | Proximal Tubular Phosphate Reabsorption: Molecular Mechanisms | Physiological Reviews | 2000 | 460 |
| 13 | Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells | Journal of Cell Science | 2004 | 433 |
| 14 | Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function | Nature Communications | 2016 | 412 |
| 15 | Mechanisms and consequences of intestinal dysbiosis | Cellular and Molecular Life Sciences | 2017 | 401 |
| 16 | Renal Vacuolar H+-ATPase | Physiological Reviews | 2004 | 397 |
| 17 | High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells | Circulation | 2003 | 389 |
| 18 | Selectins promote tumor metastasis | Seminars in Cancer Biology | 2010 | 381 |
| 19 | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins | International Journal of Cell Biology | 2012 | 378 |
| 20 | The Current State of Peritoneal Dialysis | Journal of the American Society of Nephrology: JASN | 2016 | 366 |
| 21 | Expression cloning of human and rat renal cortex Na/Pi cotransport. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 356 |
| 22 | Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis | Nature Genetics | 2012 | 356 |
| 23 | Reduced Endothelial Nitric Oxide Synthase Expression and Production in Human Atherosclerosis | Circulation | 1998 | 354 |
| 24 | New fundamental resistance exercise determinants of molecular and cellular muscle adaptations | European Journal of Applied Physiology | 2006 | 317 |
| 25 | Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression | Nature Medicine | 2013 | 317 |
| 26 | LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine | Journal of Biological Chemistry | 1999 | 314 |
| 27 | Factors influencing success of clinical genome sequencing across a broad spectrum of disorders | Nature Genetics | 2015 | 310 |
| 28 | Opioid‐mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans | Journal of Physiology | 2009 | 309 |
| 29 | Altered Tumor-Cell Glycosylation Promotes Metastasis | Frontiers in Oncology | 2014 | 308 |
| 30 | Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker | Science Translational Medicine | 2015 | 304 |
| 31 | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 285 |
| 32 | Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management—A KDIGO consensus report | Kidney International | 2015 | 276 |
| 33 | Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder | Nature Genetics | 2004 | 272 |
| 34 | Activation of system L heterodimeric amino acid exchangers by intracellular substrates | EMBO Journal | 2002 | 268 |
| 35 | RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction | Cardiovascular Research | 2014 | 257 |
| 36 | Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway | Cancer Cell | 2012 | 256 |
| 37 | Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels | Nature Genetics | 2019 | 251 |
| 38 | Biology of the Endothelium | Clinical Cardiology | 1997 | 243 |
| 39 | Refuting the myth of non‐response to exercise training: ‘non‐responders’ do respond to higher dose of training | Journal of Physiology | 2017 | 240 |
| 40 | Reduction of Selenite and Detoxification of Elemental Selenium by the Phototrophic Bacterium Rhodospirillum rubrum | Applied and Environmental Microbiology | 1999 | 236 |
| 41 | Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family | EMBO Journal | 1999 | 236 |
| 42 | High-Density Lipoprotein | Circulation Research | 2014 | 236 |
| 43 | The Arabidopsis vacuolar malate channel is a member of the ALMT family | Plant Journal | 2007 | 235 |
| 44 | The rediscovery of uromodulin (Tamm–Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease | Kidney International | 2011 | 235 |
| 45 | System L: heteromeric exchangers of large, neutral amino acids involved in directional transport | Pflugers Archiv European Journal of Physiology | 2003 | 233 |
| 46 | Glymphatic solute transport does not require bulk flow | Scientific Reports | 2016 | 231 |
| 47 | Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference | Kidney International | 2017 | 230 |
| 48 | Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation | Nature Communications | 2017 | 224 |
| 49 | Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease | Experimental Gerontology | 2005 | 221 |
| 50 | Uromodulin: from physiology to rare and complex kidney disorders | Nature Reviews Nephrology | 2017 | 220 |
