| # | Title | Journal | Year | Citations |
|---|
| 1 | Insulin and insulin-like growth factor signalling in neoplasia | Nature Reviews Cancer | 2008 | 1,792 |
| 2 | Diabetes and Cancer | Diabetes Care | 2010 | 1,618 |
| 3 | Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells | Cancer Research | 2006 | 972 |
| 4 | Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin) | Journal of the National Cancer Institute | 2001 | 815 |
| 5 | Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions | Nature Nanotechnology | 2016 | 810 |
| 6 | Diabetes and Cancer: A Consensus Report | Ca-A Cancer Journal for Clinicians | 2010 | 724 |
| 7 | The McGill Quality of Life Questionnaire: a measure of quality of life appropriate for people with advanced disease. A preliminary study of validity and acceptability | Palliative Medicine | 1995 | 604 |
| 8 | A Review of Cancer Immunotherapy: From the Past, to the Present, to the Future | Current Oncology | 2020 | 554 |
| 9 | Nutritional Recommendations for the Management of Sarcopenia | Journal of the American Medical Directors Association | 2010 | 548 |
| 10 | Epidemiology of Acquisition and Clearance of Cervical Human Papillomavirus Infection in Women from a High‐Risk Area for Cervical Cancer | Journal of Infectious Diseases | 1999 | 536 |
| 11 | Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: Report of Radiation Therapy Oncology Group 93-05 protocol | International Journal of Radiation Oncology Biology Physics | 2004 | 527 |
| 12 | Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development | Nature Medicine | 2014 | 510 |
| 13 | Pten in stromal fibroblasts suppresses mammary epithelial tumours | Nature | 2009 | 475 |
| 14 | Persistent Human Papillomavirus Infection as a Predictor of Cervical Intraepithelial Neoplasia | JAMA - Journal of the American Medical Association | 2001 | 466 |
| 15 | Inherited Susceptibility to Common Cancers | New England Journal of Medicine | 2008 | 462 |
| 16 | ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer | Radiotherapy and Oncology | 2015 | 462 |
| 17 | Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning | Cancer Discovery | 2012 | 443 |
| 18 | Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway | Journal of Biological Chemistry | 2005 | 435 |
| 19 | A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer | Nature Genetics | 2017 | 427 |
| 20 | Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial | Annals of Oncology | 2017 | 425 |
| 21 | Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals | PLoS Genetics | 2012 | 419 |
| 22 | The Type 1 Insulin-Like Growth Factor Receptor Pathway | Clinical Cancer Research | 2008 | 387 |
| 23 | The epidemiology of genital human papillomavirus infection | Vaccine | 2006 | 383 |
| 24 | 18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneity and Functional Tumor Volume in a Multi–Cancer Site Patient Cohort | Journal of Nuclear Medicine | 2015 | 374 |
| 25 | Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit | Physica Medica | 2015 | 373 |
| 26 | Validity of the McGill Quality of Life Questionnaire in the palliative care setting: a multi-centre Canadian study demonstrating the importance of the existential domain | Palliative Medicine | 1997 | 358 |
| 27 | Existential well-being is an important determinant of quality of life: Evidence from the McGill quality of life questionnaire | | 1996 | 342 |
| 28 | A Proteomic Analysis of Arginine-methylated Protein Complexes | Molecular and Cellular Proteomics | 2003 | 323 |
| 29 | Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial | Lancet Oncology, The | 2015 | 321 |
| 30 | Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy | JAMA Oncology | 2019 | 295 |
| 31 | Pharmacokinetics, Safety, and Efficacy of Trastuzumab Administered Every Three Weeks in Combination With Paclitaxel | Journal of Clinical Oncology | 2003 | 286 |
| 32 | A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection | Nature Cell Biology | 1999 | 282 |
| 33 | The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase | Cancer Prevention Research | 2008 | 266 |
| 34 | Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers | Journal of Clinical Investigation | 2019 | 266 |
| 35 | Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions | Oncogene | 2009 | 265 |
| 36 | A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment | Breast Cancer Research | 2003 | 262 |
| 37 | The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α | Oncogene | 1999 | 255 |
| 38 | Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms | Molecular Cell | 2003 | 246 |
| 39 | Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death | Oncogene | 2000 | 240 |
| 40 | Target RNA motif and target mRNAs of the Quaking STAR protein | Nature Structural and Molecular Biology | 2005 | 240 |
| 41 | Sam68 RNA Binding Protein Is an In Vivo Substrate for Protein ArginineN-Methyltransferase 1 | Molecular Biology of the Cell | 2003 | 237 |
| 42 | The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study | BMJ, The | 2012 | 237 |
| 43 | The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers | British Journal of Cancer | 2012 | 221 |
| 44 | A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup | GeroScience | 2018 | 221 |
| 45 | Structural conservation of druggable hot spots in protein–protein interfaces | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 220 |
| 46 | Tudor Domains Bind Symmetrical Dimethylated Arginines | Journal of Biological Chemistry | 2005 | 218 |
| 47 | Glutamate Receptors and Nociception | CNS Drugs | 2001 | 216 |
| 48 | Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock | Science | 2011 | 215 |
| 49 | Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2016 | 214 |
| 50 | Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial | Lancet Oncology, The | 2017 | 214 |
