| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment | Cell Death and Disease | 2013 | 977 |
| 4 | The role and mechanisms of action of microRNAs in cancer drug resistance | Clinical Epigenetics | 2019 | 468 |
| 5 | The role of STAT3 in autophagy | Autophagy | 2015 | 354 |
| 6 | Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase Ib/II clinical trial NCT02915432 | Annals of Oncology | 2019 | 336 |
| 7 | MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges | BioMed Research International | 2015 | 251 |
| 8 | EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells | PLoS ONE | 2011 | 217 |
| 9 | Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis | Signal Transduction and Targeted Therapy | 2020 | 204 |
| 10 | Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer | JAMA - Journal of the American Medical Association | 2018 | 202 |
| 11 | Roles of PFKFB3 in cancer | Signal Transduction and Targeted Therapy | 2017 | 189 |
| 12 | Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy | Frontiers in Immunology | 2020 | 148 |
| 13 | Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity | Nature Biomedical Engineering | 2021 | 148 |
| 14 | Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy | Biomaterials | 2020 | 144 |
| 15 | Novel tetranuclear ruthenium(II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo | European Journal of Medicinal Chemistry | 2019 | 140 |
| 16 | Preoperative Probiotics Decrease Postoperative Infectious Complications of Colorectal Cancer | American Journal of the Medical Sciences | 2012 | 138 |
| 17 | Comparison of long‐term effectiveness and complications of radiofrequency ablation with hepatectomy for small hepatocellular carcinoma | Journal of Gastroenterology and Hepatology (Australia) | 2014 | 138 |
| 18 | RNA-based therapeutics: an overview and prospectus | Cell Death and Disease | 2022 | 137 |
| 19 | Reprogramming the Tumor Microenvironment through Second‐Near‐Infrared‐Window Photothermal Genome Editing of PD‐L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy | Advanced Materials | 2021 | 131 |
| 20 | Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy | Biomaterials | 2021 | 122 |
| 21 | Targeting arginine metabolism pathway to treat arginine-dependent cancers | Cancer Letters | 2015 | 116 |
| 22 | Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit | MAbs | 2019 | 97 |
| 23 | Autophagy Inhibition Enhances Daunorubicin-Induced Apoptosis in K562 Cells | PLoS ONE | 2011 | 96 |
| 24 | Delivery of CRISPR/Cas9 for therapeutic genome editing | Journal of Gene Medicine | 2019 | 93 |
| 25 | Bioinformatics Method to Predict Two Regulation Mechanism: TF–miRNA–mRNA and lncRNA–miRNA–mRNA in Pancreatic Cancer | Cell Biochemistry and Biophysics | 2014 | 90 |
| 26 | Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma | Oncotarget | 2016 | 87 |
| 27 | Nuclear factor of activated T cells in cancer development and treatment | Cancer Letters | 2015 | 86 |
| 28 | Tislelizumab in Chinese patients with advanced solid tumors: an open-label, non-comparative, phase 1/2 study | | 2020 | 86 |
| 29 | Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways | Toxicology in Vitro | 2011 | 85 |
| 30 | Regulation and function of mitophagy in development and cancer | Autophagy | 2013 | 85 |
| 31 | Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial | Journal of Thoracic Oncology | 2020 | 85 |
| 32 | Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC | Cancer Immunology, Immunotherapy | 2021 | 82 |
| 33 | Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers | Cancer Letters | 2015 | 81 |
| 34 | Epidemiological trends of tracheal, bronchus, and lung cancer at the global, regional, and national levels: a population-based study | Journal of Hematology and Oncology | 2020 | 81 |
| 35 | Attractive Pickering Emulsion Gels | Advanced Materials | 2021 | 78 |
| 36 | SOCE and cancer: Recent progress and new perspectives | International Journal of Cancer | 2016 | 77 |
| 37 | Exosomes from heat‐stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL‐6 | Immunology | 2018 | 76 |
| 38 | Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations | Theranostics | 2017 | 75 |
| 39 | Co-delivery of IOX1 and doxorubicin for antibody-independent cancer chemo-immunotherapy | Nature Communications | 2021 | 75 |
| 40 | MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications | Scientific World Journal, The | 2013 | 73 |
| 41 | Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer | Theranostics | 2019 | 73 |
| 42 | Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma | British Journal of Cancer | 2013 | 72 |
| 43 | Pickering emulsions stabilized by colloidal surfactants: Role of solid particles | Particuology | 2022 | 72 |
| 44 | Autophagy-associated immune responses and cancer immunotherapy | Oncotarget | 2016 | 71 |
| 45 | A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer | Signal Transduction and Targeted Therapy | 2018 | 71 |
| 46 | Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo | Cancer Cell International | 2013 | 70 |
| 47 | Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment | Molecular Pharmaceutics | 2015 | 70 |
| 48 | Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients | Molecular Cancer | 2016 | 69 |
| 49 | 3D‐Printed Biomimetic Systems with Synergetic Color and Shape Responses Based on Oblate Cholesteric Liquid Crystal Droplets | Advanced Materials | 2021 | 68 |
| 50 | The Role of Extracellular Vesicles: An Epigenetic View of the Cancer Microenvironment | BioMed Research International | 2015 | 67 |
